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Showing 1 to 3 of 3 for “"sulfonamide analogs"”.

  1. Molecular Considerations In The Design Of Novel Alpha/Beta Hydrolase Inhibitors

    … QSAR technology to design and optimize novel sulfonamide CES2 inhibitors; (ii) combined QSAR with in silico design to generate new CE inhibitor scaffolds that maintained the potency of previous CE inhibitor generations, yet had improved water solubility; and ( iii) investigated the …

    mississippi Repository record for Molecular Considerations In The Design Of Novel Alpha/Beta Hydrolase Inhibitors (opens in a new tab)

  2. Synthesis of Novel Sulfonamide-Based Calpain Inhibitors and Their Potential as Anti-Tumor Agents

    … screened by virtual screening method and diazosulfonamide <strong>1 </strong>(<em>K</em>i = 1.0 ± 0.02 µM) was identified as a new nonpeptide competitive inhibitor of µ-calpain. Analogues of <strong>1 </strong>were synthesized to explore structure requirements of <strong>1 </strong>(Chapter 2). …

    tenn-hsc Repository record for Synthesis of Novel Sulfonamide-Based Calpain Inhibitors and Their Potential as Anti-Tumor Agents (opens in a new tab)