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Showing 1 to 8 of 8 for “"sulfinamide"”.
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Asymmetrische Synthese 3-substituierter 4-Methylenproline und Untersuchungen zur Metathese mit vinylischen Sulfoximinen
… prolin in yields between 54 and 78%. The sulfinamide splitted off was isolated in yields greater than 81% and with an enantiomeric excess of 99%. This sulfinamide may be converted to enantiomerically pure (S)-N,S-dimethyl-S-phenylsulfoximine. The deprotection of one of the proline …
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Developing Detection Methods for Nitroxyl
… GSH reacts with HNO to produce glutathione sulfinamide (GS(O)NH₂), which is a selective biomarker of HNO. We developed an in vivo assay that indirectly detects HNO by quantifying the production of GS(O)NH₂. The free amine on GS(O)NH₂ was fluorescently labeled with NDA, and capillary zone …
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Asymmetrische Synthese von bicyclischen Alpha-Aminosäuren durch intramolekulare Pauson-Khand-Reaktion von l-Alkenylsulfoximinen und Festphasensynthese mit Allylsulfoximinen
… at the sulfur atom forming enantiomerically pure sulfinamide. The deprotection of the sulfonylamino group could be shown in one example with 85% yield. In a second part of this thesis the synthesis of polymer-bound allylic sulfoximines and their use in the asymmetric synthesis of alkenyl oxiranes …
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Preparation of N,N'-Dialkyl bis(diamino) diphenylmethanes and N,N'-Dialkyl bis(diamino) benzophenones: preparation of B-hydroxy sulfonamides and B-hydroxy sulfinamides
… yield. The attempted preparation of β-hydroxy sulfinamides involved initially the synthesis of N-methanesulfin-p-toluidide following the procedure of Corey and Durst. This compound was subsequently alkylated with sodium hydride and methyl iodide in 1.2-dimethoxyethane in 76% yield. Treatment of …
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Method development for the comprehensive analysis of post translational modifications by mass spectometry
… HNO-induced modifications, fragmentation of the sulfinamide- and sulfinic acid-modified peptides produced a neutral fragment of 65 Da and 66 Da, respectively. With respect to the second issue, a multiplexed technique for monitoring modifications that fragment as neutral losses, termed Multiple …
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Asymmetrische Synthese ausgehend von allylischen Sulfoximinen: neuartige Gamma-Aminosäuren und cyclische Aminosulfoxonium Ylide
… could be recovered as a sulfinamide isolated in enantiomerically pure form. There are literature known methods for its transformation into the starting chiral auxiliary. Moreover a new one step method for the cleavage of the sulfoximine moiety under introduction of an …
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Understanding the crystal landscape of primary sulfinamides and predicting cocrystallization
… in the synthesis of a library of primary aryl sulfinamides, an under-studied sulfur functional group from a solid state chemistry perspective. Their solid-state properties are examined, with focus on the robust supramolecular synthons that they exhibit. Finally, this chapter describes their …
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Synthese neuartiger Sulfonimidamide zur Anwendung in der asymmetrischen Katalyse
In the context of this research the synthesis of novel sulfonimidamides and their modification was envisaged with regard to their application in asymmetric catalysis. The first part of this work was dedicated to the synthesis of these highly oxidized sulfur compounds. Starting from sulfinic acid …