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Showing 1 to 7 of 7 for “"sulfenic acid"”.
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Redox Regulation of T cell Activation and Function During Viral Infection
… examined the importance of reversible cysteine sulfenic acid formation in naïve CD8+ T cell activation and proliferation. We observed that within minutes of T cell activation, naïve CD8+ T cells increased ROI levels in a manner dependent upon antigen concentration. Increased ROI resulted in …
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REDOX REGULATION OF B CELL ACTIVATION AND THE ANTI-VIRAL HUMORAL IMMUNE RESPONSE
… of the reversible formation of cysteine sulfenic acid on B cell activation and proliferation. BCR ligation with anti-IgM or antigen resulted in ROI production that reaches a maximum by 15 minutes. Increased ROI coincides with elevated levels of the first oxidation product of cysteine, …
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UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY
Sulfenic acids are fleeting intermediates formed from the oxidation of cysteine thiols by a number of biologically relevant oxidants. Sulfenic acids are quickly converted to other species including disulfides, thiosulfinates, sulfinic acids, or sulfonic acids, leading to changes in protein …
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Elucidation of the Various Mechanisms of Antioxidant Activity of Organosulfur Compounds
… antioxidants (RTAs) through the intermediacy of sulfenic acids (RSOH). In an effort to shed light on the antioxidant mechanisms of other organosulfur constituents of garlic and sulfurized olefins, in Chapter 2, we reported on the antioxidant activity of trisulfide-1-oxides (RS(O)SSR) at 37 °C. In …
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Toward Engineering Oxygenase Activity into the Electron Transfer Protein Azurin
… under ambient conditions with ascorbic acid and molecular oxygen. In Chapter 2, the power of the cavity mutant approach to small molecule processing in the azurin scaffold is demonstrated through description of the first reported Cu(II)-sulfenic acid species. This species, prepared in …
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Developing an optimal method for producing a tearless onion
… synthase (LFS) specifically from 1-propenyl sulfenic acid, a breakdown product of trans-1-propenyl-L-cysteine sulfoxide (1-PRENCSO) by alliinase. This thesis describes strategies to produce a tearless onion by using RNA interference (RNAi) silencing. To determine whether a gene silencing …
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X-ray Spectroscopic Studies of Model Compounds With Relevance to Nickel Superoxide Dismutase, Nitrile Hydratase and Copper Related Neurodegenerative Disorders
… active form, a sulfinate (SO<sub>2</sub>) and a sulfenic acid (SOH). Over or under oxidation result in no activity of the metellopeptide mimic. The Aβ (amyloid-β) peptide and the PrP (prion protein) were investigated to determine Cu coordination environments. The Aβ peptide forms …