Global ETD Search
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Showing 1 to 4 of 4 for “"sulfatides"”.
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Sulfatides mediate Disabled-2 membrane localization and stability during platelet aggregation
… binding on the activated platelet surface.3 Sulfatides are also found on the platelet surface,4 interacting with adhesive and coagulation proteins5-7 and, thus, they are thought to play a major role in haemostasis and thrombogenesis. Here, we show that the Dab2 PTB domain specifically …
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Membrane binding properties of Disabled-2
… within the PTB domain. Alternatively, Dab2 binds sulfatides on the platelets surface, and this binding partition Dab2 in two pools (sulfatide and integrin receptor-bound states), but the biological consequences of lipid binding remain unclear. Dab2 binds sulfatides through two basic motifs located …
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Disabled-2 regulates platelet heterotypic and homotypic aggregation through sulfatide binding
… interactions. Dab2 is also capable of binding to sulfatides, through the N-PTB region, expressed on the outer leaflet of adjacent cells. Dab2-sulfatide binding decreases Dab2's ability to interact with the αIIbβ3 integrin, however sulfatides activate and stimulate platelet-platelet and …
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Molecular characterization of soybean meal trypsin inhibitors and lectins as a basis for developing approaches to mitigate their anti-nutritional effects
… out that soybean lectin crosslinks and binds to sulfatides with a high affinity, in a process that could result in unwanted signaling events in the body, making this another soybean lectin antinutritional pathway. This discovery could also lead to the design of suitable additives to target the …