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Showing 1 to 4 of 4 for “"sulfamidate"”.
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Design, Synthesis and Biological Evaluation of Therapeutic B2,2 -Sulfamidate-Containing Peptides
A lo largo de esta Tesis Doctoral se han presentado varios resultados experimentales y teóricos, que permiten establecer estas conclusiones: Se ha estudiado la reactividad de sulfamidatos que presentan alfa-metilisoserina en su estructura combinando técnicas experimentales y cálculos …
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Síntesis y reactividad de sulfamidatos cíclicos derivados de aminoácidos
… α- and β-amino acids by opening different cyclic sulfamidates in a stereospecific and regioselective manner. Thus, an study of the synthesis and reactivity of different amino acid-derived cyclic sulfamidates against nucleophiles of different nature has been carried out. Firstly, in chapter 3 a …
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Synthetic Routes to Therapeutic Agents Via Masked Functionalities: From Orthogonal Peptide Crosslink to Photothermal Cancer Prodrug
… nucleophilic opening of a five-membered ring sulfamidate (derived from Fmoc-D-Ser-OH) by Boc-L-His-OTCE led to preparation of a regiochemically and stereochemically pure ô-HAL derivative. Thus, a new set of orthogonal protecting groups have been identified: Fluorenylmethyloxycarbonyl (Fmoc), …
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Synthesis and Biological Studies of Lanthionine Derivatives
… with a cysteine on the β carbon of cyclic sulfamidate precursors was highly successful, despite the sterically crowded α-carbon. In this way, we have obtained several protected α-alkyl lanthionines. These products are promising building blocks for peptide synthesis. In this report, we also …