Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"suicide gene therapy"”.
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Suicide Gene therapy for Malignant Gilomas using Neural Stem Cells
… stem cell (HB1.F3) transduced with suicidal gene using the tropism of stem cells. MATERIALS AND METHODS: E.coli cytosine deaminase(CD) of suicide gene is enzyme that catalyzes the conversion of noncytotoxic 5-FC to the cytotoxic and radiosensitizing drug 5-FU. Cytotoxic 5-FU and its toxic …
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Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer
… disease. Current treatment options include radiotherapy, surgery and hormone therapy, however 1/3 patients escape from all therapies and novel therapies are urgently required for this patient group. The University of Birmingham gene therapy group constructed two oncolytic adenovirus vectors, …
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Viral HSV1-TK gene, radiolabeled FIAU, and ganciclovir: combined gene targeted radiotherapy and suicide gene therapy for prostate cancer
The strategy of suicide gene therapy in cancer is based on the idea of enabling tumour cells, by gene transfer, to convert a non-toxic pro-drug into a toxic product. Previous work has shown that the combination of herpes simplex virus type 1 thymidine kinase gene (HSV1-tk) transfer with the …
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Targeted gene therapy for canine osteosarcoma: preliminary investigations
… and <20% survive >2 years with standard therapy. Hence, new approaches must be considered. TP53 is altered in ~50% of human and canine cancers, including OS, making it a candidate for targeted suicide gene therapy strategies. Canine OS is considered to be a good model for human OS. The …
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Induzierter Zelltod von transdifferenzierten hepatischen Sternzellen (Myofibroblasten) auf der Basis des Thymidinkinase-Ganciclovir-Systems
… a prophylaxis in oder to prevent liver fibrogenesis. The intention was to eliminate activated hepatic stellate cells (HSC), those cells which became proliferative, fibrogenetic and contractile because of liver injury. Activated HSC are called myofibroblasts. They are mainly responsible for …