Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"suicide gene"”.
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Suicide Gene therapy for Malignant Gilomas using Neural Stem Cells
… stem cell (HB1.F3) transduced with suicidal gene using the tropism of stem cells. MATERIALS AND METHODS: E.coli cytosine deaminase(CD) of suicide gene is enzyme that catalyzes the conversion of noncytotoxic 5-FC to the cytotoxic and radiosensitizing drug 5-FU. Cytotoxic 5-FU and its toxic …
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Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer
… this patient group. The University of Birmingham gene therapy group constructed two oncolytic adenovirus vectors, CRAd-NTR and vNR6, both of which contained the E1B-55K deletion and expressed the transgene nitroreductase for combined oncolytic virotherapy and enzyme/prodrug gene therapy. The …
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Characterization of Genetically Modified Mesenchymal Stem Cells with a Retroviral Vector Expressing a Suicide Gene
… cellular vehicles to deliver therapeutic genes for ex-vivo therapy of diverse diseases because they have the capability to migrate into tumor or lesion sites. Previously, we showed that mesenchymal stem cells could be utilized as a cellular vehicle to deliver a bacterial cytosine deaminase …
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Viral HSV1-TK gene, radiolabeled FIAU, and ganciclovir: combined gene targeted radiotherapy and suicide gene therapy for prostate cancer
The strategy of suicide gene therapy in cancer is based on the idea of enabling tumour cells, by gene transfer, to convert a non-toxic pro-drug into a toxic product. Previous work has shown that the combination of herpes simplex virus type 1 thymidine kinase gene (HSV1-tk) transfer with the …
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Targeted gene therapy for canine osteosarcoma: preliminary investigations
… including OS, making it a candidate for targeted suicide gene therapy strategies. Canine OS is considered to be a good model for human OS. The aims of this study were to: examine the site incidence of canine OS retrieved from Glasgow University Veterinary School (GUVS) histology database; …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… Herpes simplex virus thymidine kinase-mediated gene therapy of intracranial tumors for molecular genetic imaging and suicide gene delivery with ganciclovir. Finally, we expand our data by analyzing a large panel of primary CNS tumors through comprehensive tissue microarrays. Together, our …
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Tumor Response TCF-4/β-Catenin Regulatory Elements for Enhancing Cancer Gene Therapies
<p>Mutations in the adenomatous polyposis coli gene are frequently associated with progression of colon carcinoma and most other types of epithelial carcinomas. This usually results in stabilization of β-catenin protein levels, followed by transactivation of Tcf-4/β-catenin responsive genes. The …
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Manipulation of the Moloney Murine Leukemia Virus Envelope Protein in an Effort to Develop Directly and Indirectly Targeted Retroviral Vectors for Use in Human Gene Therapy
… to the use of replication deficient retroviral gene therapy vectors with interchangeable receptor binding sites. These vectors may be used separately or in combination with each other to ensure maximum delivery of a suicide gene only to cancerous cells involved with the primary tumor as well as …
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Induzierter Zelltod von transdifferenzierten hepatischen Sternzellen (Myofibroblasten) auf der Basis des Thymidinkinase-Ganciclovir-Systems
… a prophylaxis in oder to prevent liver fibrogenesis. The intention was to eliminate activated hepatic stellate cells (HSC), those cells which became proliferative, fibrogenetic and contractile because of liver injury. Activated HSC are called myofibroblasts. They are mainly responsible for …