Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"sugar phosphate"”.
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Mechanistic and physiological insights into post-transcriptional regulation by small RNAs SgrS and DicF
… to a growth inhibitory stress condition called sugar-phosphate stress caused by the toxic accumulation of phosphorylated sugars. SgrS combats this stress with its RNA base pairing function by silencing translation of sugar transporters that import the stress molecules. SgrS was previously shown …
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Squaramide-Naphthalimide Conjugates as Potential Self-Assembled Materials and as DNA Binders
… as a DNA binder to the negatively charged sugar phosphate backbone was discussed. Bis-intercalators were also described in detail and their strong DNA bis-intercalating ability was also discussed. The proposed target bis-intercalators were introduced, with multiple modes of binding to DNA, …
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The application of gas liquid chromatography to the simultaneous analysis of sugars and sugar phosphates in biological samples /|nby David J. LeBlanc. -- 260 St. Catharines [Ont. : s. n.],
… chromatography to the simultaneous analysis of sugars and sugar phosphates from biological samples. A new method of silylation involving dimethylsulfoxide, hexamethyldisilazane, trimethylchlorosilane and cyclohexane (1:0.2:0.1:1) which rapidly silylated sugars and sugar phosphates was developed. …
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In Vitro Synthetic Biology Platform and Protein Engineering for Biorefinery
… fuel, hydrogen, and two high-value chemicals, a sugar phosphate and a highly marketable sweetener, representing a new portfolio for new biorefineries. Hydrogen gas is a promising future energy carrier as a transportation fuel, offering a high energy conversion efficiency via fuel cells, nearly …
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Molecular Dynamics Study of Single Stranded Peptide Nucleic Acids
<p>A PNA molecule is a DNA strand where the sugar-phosphate backbone has been replaced by a structurally homomorphous pseudopeptide chain consisting of <em>N</em>(2-aminoethyl)-glycine units. PNA binds strongly to both DNA and RNA. However, an analysis of the X-ray and NMR data show that the …
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A combined EMR and DFT study of radiation-induced defects in sucrose and glucose 1-phosphate
… in solid sucrose (also known as common household sugar) and in the dipotassium salt of glucose 1-phosphate (K2G1P). The radiation chemistry of these materials is relevant in the context of radiation damage to DNA and (emergency) dosimetry. Next to the actual research results, which will be …
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Self -Assembly Between Biomacromolecules and Lipids
… polar planes parallel to the negatively charged sugar-phosphate DNA backbone, which indicates that molecular details of the DNA molecule are imprinted onto the inorganic crystal structure. The resultant nanorods have (002) planes tilted by ∼60° with respect to the rod axis, in contrast to …
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Purification and characterization of a poly(dG).poly(dC)-binding protein from Parenchinus angulosis
… groove. Contacts are made to one of the DNA sugar phosphate backbones abutting this major groove. The data is consistent with the DNA in the complex being curved, and/ or exhibiting a sharp bend at the site of suGFl contact in the major groove. suGFl does not seem to bind to DNA as a …
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Microgap Structured Optical Sensor for Fast Label-free DNA Detection
… technology. Subsequently, considering the sugar phosphate backbone of DNA, layer-by-layer electrostatic self-assembly technique is adopted to attach the single strand capture DNA to the sensor endface. When the target DNA strand binds to the single-stranded DNA successfully, the optical …
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Yeast engineering for pharmaceutical and nutraceutical purposes
… pathway during utilization of fermentable sugars. Since the ethanol pathway plays a key role in cytosolic acetyl-CoA synthesis and redox balance of Saccharomyces, new metabolic engineering approaches not to knock out its ethanol pathway but to minimize the overflow metabolism are needed for …
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Understanding consumer liking of beef with particular reference to flavour
… the effects of enhancement (kiwi, fig and phosphate solutions) and tenderisation on meat quality with instrumental and chemical analyses. Sugar concentrations were significantly increased and sugar phosphate concentrations were significantly decreased for enhanced beef samples compared to …
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Modulation of Cis-syn Cyclobutane Dimer Formation and Deamination at CpG sites by Nucleosome Particles and Its Implications for Deamination Bypass Mechanism for the Origin of C to T Mutations
… We found that the deamination of a TmC CPD whose sugar phosphate backbone is positioned against the histone core surface decreases by a factor of 4.7, whereas that of a TmC CPD positioned away from the surface increases by a factor of 8.9 when compared with unbound DNA. Considering that formation …
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Synthesis of internal amide bond short interfering RNAs (siRNAs) and investigation of their gene silencing properties
… chemical properties. For example, the sugar-phosphate backbone contains a negative charge which hinders its ability to cross the negatively charged lipid bilayer. Furthermore, the phosphodiester backbone is a substrate for nucleases, which catalytically cleaves the phosphate-oxygen …
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Developing high-resolution methods to study DNA and RNA dynamics
… at post-transcriptional level in response to sugar-phosphate stress. It is known that sgrS anneals target transcripts via basepairing interaction with the guide of Hfq protein. Nevertheless, how individual nucleotides within sgrS sequence contribute to the regulation process is not clear. Here …
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Molecular analysis of small RNA and small protein regulation of Escherichia coli stress responses
… Both molecules are expressed during glucose-phosphate stress - a bacteriostatic condition in which phosphosugars accumulate in the cell either because of mutations in glycolysis or because of the transport of non-metabolizable glucose analogs such as αMG or 2DG. While both SgrT and SgrS base …
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Zuckerphosphate als Vorläufer von 4-Hydroxy-3(2H)-furanonen - Biochemische Transformation durch die Hefe Zygosaccharomyces rouxii und chemische Bildung unter physiologischen Bedingungen
… die Bildung dieser Verbindungen aus Zuckerphosphaten unter physiologischen Reaktionsbedingungen. Ein Schwerpunkt der Arbeiten lag dabei auf der Bildung von HDMF aus D-Fructose-1,6-diphosphat (Fru-1,6-dP) durch den Hefestamm Zygosaccharomyces rouxii. Der Zusatz von 1-13C-Fru-1,6-dP bzw. …
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Redox-regulation of starch and lipid synthesis in leaves
… enzymes of the Calvin cycle, oxidative pentose phosphate cycle, NADPH export and ATP synthesis in response to light. The aim of the present thesis was to investigate whether a similar mechanism is also regulating carbon storage in leaves. Previous studies have shown that the key-regulatory …
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EMISSIVE PEPTIDE NUCLEIC ACIDS (PNAS): POTENTIAL TOOLS FOR INNOVATIVE DIAGNOSTICS AND THERAPEUTICS
… in which the chiral and negatively charged sugar-phosphate backbone is replaced by achiral and neutral N-(2-aminoethyl)-glycine (aeg) units, where the four nucleobases (thymine, adenine, cytosine, guanine) are inserted through a carboxymethylene spacer. PNAs are able to bind complementary …