Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"sugar nucleotide"”.
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Targeting final steps of sugar nucleotide biosynthetic pathway against <i>Aspergillus fumigatus</i>
… which are membraneembedded enzymes that convert sugar nucleotides to cell wall carbohydrates. Therefore, targeting Leloir glycosyltransferases may affect cell wall carbohydrates and in turn elicit antifungal activity, i.e., Leloir glycosyltransferases are potential antifungal targets against A. …
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Biochemical characterization of Cj 1123 c, a putative acetyltransferase & Cj 1319, a putative C6 dehydratase from Campylobacter jejuni.
… O-acetylate UDP-GlcNAc, thereby generating novel sugars. We demonstrate that Cj 1319 converts GDP-mannose with low conversion efficiency, suggesting that it is not the ideal substrate. We observed a buildup of a sugar-nucleotide within a Cjl319~ deficient strain that may represent the true …
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Elucidation and Characterization of Glycosyltransferases Implicated in Pectic Polysaccharide Biosynthesis in Arabidopsis thaliana
… are enzymes that catalyze the transfer of a sugar molecule from an activated sugar-nucleotide donor to an acceptor substrate, and these enzymes are responsible for cell wall polysaccharide synthesis. Across plant and metazoan organisms, mutant phenotypes for many GTs result in developmental …
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Discovery of Glyco-biomarkers for Diabetes and Complications in Diabetes
… elevated hexosamine flux in diabetes elevating sugar nucleotide levels. This, in turn, might affect the N-glycan branching pathway and result in detectable changes in plasma glycoprotein glycoforms.<br/>The aim of the study was to discover potential glyco-biomarkers for diabetes and complication …
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Improving Brassica napus straw for cellulosic ethanol production
… transcriptome suggested that genes involved in sugar nucleotide provisioning, the endogenous hydrolysis of cellulose and non-cellulosic polysaccharide synthesis were related to saccharification yields. Candidate genes aid in the development of testable hypotheses related to biomass recalcitrance …
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Production of a functional human milk oligosaccharide, 2'-fucosyllactose, using microbial cell factories
… was identified. GDP-L-fucose is a beneficial sugar nucleotide which serves as a precursor to innumerable compounds aside from 2-FL. From this study, the feasibility and scalability of employing the microbial cell factory approach for 2-FL and GDP-L-fucose production were manifested.
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Design and synthesis of inhibitors of dTDP-D-glucose 4,6-dehydrate (Rm1B), and enzyme required for dTDP-L-rhamnose production in M. tuberculosis
… understanding of the mechanism and mimic the sugar portion of the sugar-nucleotide substrate at various steps throughout the reaction mechanism. Each of the proposed inhibitors is designed to inhibit one of the specific steps of the mechanism. While the intention of this project is to …
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"Sugar Coat" Genetic & chemical validation of <i>Aspergillus fumigatus</i> cell wall targets
… chitin synthesis upstream by inhibition of the sugar nucleotide substrate UDPGlcNAc. Finally, UDP-galactopyranose mutase (UGM) is the sole source of the galactofuranose sugar that forms short crosslinks in the outer layer of galactomannan.<br/><br/>The underlying hypothesis is that gene deletion …
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Biosynthesis of Nucleotide Sugar Monomers for Exopolysaccharide Production in Myxococcus Xanthus
… M. xanthus does not use glucose or any other sugar as a primary carbon source. However, eight monosaccharides, namely glucose, mannose, arabinose, galactose, xylose, rhamnose, N-acetyl-glucosamine, and N-acetyl-mannosamine, are found in M. xanthus EPS. In this study, pathways that M. xanthus …
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Clarification of the xanthan biosynthesis mechanism in Xanthomonas campestris pv. campestris B100 by mass spectrometry-based proteome analysis
… Gdh and GlnA. The levels of proteins involved in sugar nucleotide metabolism remained constant throughout all stages of growth. Except for GumD, GumB, and GumC, the gum proteins exhibited no notable variations during the study. GumD, the primary enzyme forming the xanthan-repeating unit, peaked …