Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"sudden cardiac death"”.
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Genetic Variants and Risk in Sudden Cardiac Death Syndromes
Sudden cardiac death is a major public health burden and is often the first manifestation of heart disease. Several cardiac conditions that confer a predisposition to sudden cardiac death (SCD) have a known genetic basis, including for example long QT syndrome (LQTS) and hypertrophic cardiomyopathy …
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The Family Study: Assessment of the Incidence, Etiology, Circumstances and Familial Risk for Sudden Cardiac Death and Aborted Sudden Cardiac Death in Young Individuals
… on the incidence etiology and circumstances of sudden death (SD) in the young, particularly the distribution of underlying disorders, preventable triggers, and identifiable familial predisposition to fatal arrhythmias. Methods: This study had 3 parts: (1) the development and (2) implementation …
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Athletes heart and exercise related sudden cardiac death: Across the age span
… risk of cardiovascular disease and subsequent sudden cardiac death (SCD). However, a small, but notable proportion of athletes die suddenly due to inherited or congenital disorders of the heart that predispose to malignant ventricular arrhythmias. Such tragedies are highly publicised, …
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Embodied revelation: The threat of sudden cardiac death for implantable cardioverter defibrillator candidates
… by high mortality and high morbidity. Sudden cardiac death is the leading cause of death for people with heart failure as well as the primary cause of death in the United States. Implantable cardioverter defibrillators (ICDs) represent the standard of care as the only effective therapy …
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Arrhythmia heart disease classification using deep learning
… affects millions of people in the world. Sudden cardiac death is the cause about half of deaths due to cardiovascular disease and about 15% of all deaths globally. About 80% of sudden cardiac death is the result of ventricular arrhythmias. Arrhythmias may occur at any age but are more …
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Modeling the Effects of Mechanical Loading on Hypertrophic Cardiomyopathy Pathogenesis in Human Induced Pluripotent Stem Cell derived Micro Heart Muscle
<p>Sudden cardiac death in the young is devastating. Advances in genetics have associated mutations in the contractile sarcomere apparatus of cardiomyocytes with hypertrophic cardiomyopathy, the most frequent cause of sudden cardiac death in the young. Currently, it is challenging to predict …
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Mechanisms of ventricular arrhythmogenesis in the age dependent Pgc-1β -/- model of mitochondrial dysfunction.
Sudden cardiac death is a leading cause of mortality worldwide. Ventricular arrhythmias, both ventricular tachycardia and ventricular fibrillation, are the primary arrhythmias that lead to sudden cardiac death. A large proportion of ventricular arrhythmias are ischaemic in origin. However, …
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Hypertrophic Cardiomyopathy: A Review of Clinical and Molecular Characteristics and Effects and A Clinical Case Study
… HCM is considered the most common cause of sudden cardiac death in young athletes. Mutations of the myosin-binding protein C (cMyBP-C) have been targeted as one of the most prevalent causes of this disease, and the deactivating effects of such mutant forms on the quality control …
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Exercise-Associated Cardiac Rhythm Disorders in Thoroughbred Racehorses
Cardiac arrhythmias negatively impact horseracing through concerns for horse and jockey safety and welfare. The most clinically relevant rhythm disorders in Thoroughbred racehorses (TBs) are atrial fibrillation (AF), which typically causes poor performance, and fatal arrhythmias which precipitate …
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The Experiences of Women Who Live with an Implantable Cardioverter-Defibrillator (lCD)
… lifesaving therapy to patients at risk for sudden cardiac death. Currently, 150,000 Americans receive ICDs each year. Although most lCD recipients are men, more women are now qualifying for insertion (Stutts, Cross, Conti, & Sears, 2007). Despite its established health benefits, lCD …
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An analysis of defibrillation and cardiac resynchronization therapy strategies in patients with failing systemic right ventricles
The expanding application of cardiac resynchronization (CRT) and implantable cardioverter-defibrillator therapy (lCD) to include patients with congenital heart disease requires careful evaluation of selection criteria and unconventional adaptive strategies to ensure clinical efficacy. A single …
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Arrhythmogenic Right Ventricular Cardiomyopathy: From Surviving to Thriving
… inherited disease, and a leading cause of sudden cardiac death in young, otherwise healthy adolescents and adults. Through the advances of modern technology, those who receive this once-devastating diagnosis, now stand an excellent chance at survival through the use of medication and a …
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Computational methods for physiological data
… of cardiovascular mortality (almost 30% of all deaths worldwide each year). When evaluated on ECG data from over 4,500 patients, high MV was strongly associated with both cardiovascular death and sudden cardiac death. MV was a better predictor of these events than other ECG-based metrics. …
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Extended electrocardiographic monitoring in patients on chronic haemodialysis and after renal transplantation
… disease. Despite the increased risk of sudden cardiac death, few studies to date have described the burden of arrhythmias in this population. The aim of this study was to determine the prevalence, type and timing of arrhythmias by means of implantable loop recorder (ILR) monitoring in …
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New Paradigm of Defibrillation: Towards Painless Therapy
Sudden cardiac death: SCD) causes approximately 300,000 - 400,000 deaths a year in the United States. It usually starts as ventricular tachycardia: VT) and then degenerates into ventricular fibrillation: VF). Implantable cardioverter defibrillator: ICD) therapy is the only reliable treatment of …
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Sodium Channel Loss of Function Sensitizes Conduction to Changes in Extracellular Sodium Concentration
Sudden cardiac death is largely attributable to sudden onset ventricular arrhythmias. Alterations in cardiac conduction, particularly the slowing of conduction velocity is one major factor in arrhythmogenesis. By understanding the mechanisms and factors that modulate cardiac conduction velocity, we …
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Development of a Model System for Culturing Neonatal Rat Ventricular Myocytes in vitro to Monitor Integrin Activation in Response to Altered Contractile Force
… 500 individuals and remains the leading cause of sudden cardiac death (SCD) in young adults. Recent evidence links mutations within sarcomeric proteins to the HCM disease state. The interplay between the forces generated by the contractile apparatus and sensed by integrins is central to …
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Circadian Rhythm in Intrinsic Heart Rate
Heart rate (HR) as well as adverse cardiac events (i.e. myocardial infarction, arrhythmias, stroke, and sudden cardiac death) show circadian patterns. Circadian HR fluctuations are traditionally thought to be controlled by the autonomic nervous system (ANS). However, recent studies have concluded …
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Incidence and Clinical Predictors of Risk Factors for Inappropriate Shock in Patients with Implantable Cardioverter-Defibrillators
Sudden cardiac death (SCD) is a major unresolved medical problem worldwide. Although Implantable Cardioverter-Defibrillators (ICD) are highly effective in diagnosing and treating life threatening arrhythmias, inappropriate shock therapy (IST) occurs in approximately 5-20% of ICD recipients. IST …
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Dobutamine stress magnetic resonance imaging in tetralogy of fallot
This thesis evaluates the role of cardiac magnetic resonance (CMR) imaging in the assessment of patients with surgically repaired tetralogy of Fallot (TOF). CMR has become a powerful tool in the serial assessment of this group of patients and provides important information on cardiac structure and …
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