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Showing 1 to 5 of 5 for “"succinyl-CoA synthetase"”.
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Understanding the Mechanism of Succinyl-CoA Synthetase Catalysis from Structural Studies
The catalytic mechanism of succinyl-CoA synthetase (SCS) was investigated using X-ray crystallography. Two nucleotide-specific forms of SCS exist in mammals, of which one is ATP-specific (ATPSCS) and the other is GTP-specific (GTPSCS). ATPSCS and GTPSCS share the same α-subunit, but have a …
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Investigation into Tissue-Specific Mechanisms of Mitochondrial Dysfunction: Models of SUCLA2 Deficiency and a Screen for Potential Genetic Modifiers
… used to generate tissue-specific mouse models of succinyl-CoA synthetase deficiency, which is a known cause of mitochondrial disease in humans. In parallel, forward genetics is used to screen for variation in mitochondrial phenotypes in a genetically diverse population of mice to identify …
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Protein Phosphorylation in Archaea
… this phosphoprotein as the a-subunit of succinyl-CoA synthetase. N-terminal sequence analysis and enzymatic assays revealed that the 50 kDa phosphoprotein was a hexosephosphate mutase. Neither the 50 kDa nor the 35 kDa phosphoprotein appeared to be the target of protein kinases or …
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Kompartementalisierung des Kohlenhydrat-Stoffwechsels in Toxoplasma gondii
… im Apicoplasten erklärt den Ursprung des Acetyl-CoAs, welches für die Fettsäuresynthese in diesem Organell benötigt wird. Auch die in dieser Arbeit identifizierten Isoenzyme der Pyruvat-Kinase, Triosephosphat-Isomerase und Phosphoglycerat-Kinase wurden mittels Epitop-tagging im …
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Biochemical Characterization of <i>Toxoplasma gondii</i> Type II NADH Dehydrogenases - Physiological Impact on Mitochondrial Functions and Energy Metabolism
… A parasite line expressing a matrix-localized succinyl-CoA synthetase beta subunit (TgSCSβ)-GFP1-10 fusion protein was generated and transfected with TgNDH2-I-GFP11 or TgNDH2-II-GFP11 fusion constructs. Full-length constructs of TgNDH2-II and truncated versions of TgNDH2-I were able to …