Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"subventricular zone"”.
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Cell proliferation and metal accumulation in the subventricular zone and olfactory bulb in Parkinson’s disease
… this olfactory dysfunction include a decrease in subventricular zone neurogenesis, caused by dopaminergic denervation of this region, or an accumulation of metals from the environment. In this thesis, immunohistochemistry was used to investigate proliferation levels and dopamine receptor abundance …
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A Niche for Adult Neurogenesis: Analysis of BMP Signaling and Transcriptional Profiles of Adult Subventricular Zone Cells
… The largest region of adult neurogenesis is the subventricular zone (SVZ) of the lateral ventricle wall. Neural stem cells reside in the SVZ. The SVZ cell types and molecular signals necessary for this neurogenic niche were poorly understood. Here, I first demonstrate that astrocyte-like cells in …
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Characterization of Cu-rich aggregates in neurogenic niches of the rodent brain by X-ray fluorescence microscopy
… in the hundreds of millimolar are present in the subventricular zone of rats and mice. As the subventricular zone is a neurogenic niche in the adult brain, the hippocampal dentate gyrus and rostral migratory stream were also examined to see if these aggregates were present. It is shown that rats, …
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On the origins of glioma: insights from brain network mapping
… gliomas originate from neural stem cells in the subventricular zone, as well as other work in mouse models demonstrating that gliomas infiltrate previously healthy brain networks. This thesis contributes three studies of clinical datasets which evaluate the hypothesis that glioma initiation and …
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Progenitor cells in the postnatal central nervous system, characterization and genetic manipulation
… in two places of the postnatal brain; the subventricular zone (SVZ) and hippocampus. The SVZ-derived cells specifically migrate to the olfactory bulb where they give rise to new interneurons. We have genetically manipulated the postnatal SVZ progenitor cells with the aim to direct them to a …
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Pten Function in Postnatal Brain Development and Tumorigenesis
… are generated every day throughout life in the subventricular zone (SVZ) and migrate through the rostral migratory stream (RMS) to the olfactory bulb where they differentiate into mature interneurons. The signaling pathways instructing when and where these tangentially migrating neuroblasts stop …
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The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis
… ability to generate new neurons: the subgranular zone of the hippocampus (SGZ) and the subventricular zone (SVZ) lining the lateral ventricles in the forebrain. Several studies have suggested that SVZ neural progenitor cells in the adult brain can migrate into regions other than the olfactory bulb …
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The Tumor-Suppressive Properties of Neural Stem Cells
… GBM formation can stimulate the neurogenic subventricular zone of the cerebral cortex and causes the proliferation and migration of neural stem cells (NSCs) towards the tumor. This migration reflects the NSC wound repair response following CNS injury. Studies using NSCs surgically implanted …
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Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… Increased fluorescent intensity of AQP4 in the subventricular zone and increased AQP1 apical localization and protein amount in the CP was observed in hydrocephalic animals at postnatal day (P)15. Many of these may be targeted for the treatment of hydrocephalus. However, there is no consensus in …
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Determinants of cns adult neurogenesis are sex, hormones, mouse strain, age, and brain region
… normal C57BL/6, SJL/J and BALB/c mice in the subventricular zone (SVZ), dorsolateral horn (DLC), corpus callosum (CC), and parenchyma. With a short 2 h BrdU pulse, no gender and strain differences are present at 6-8wk. At 6-8mo, the number of BrdU+ cells decreases 2-fold in both sexes, strains …
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Analysis of Β8 Integrin In Neurogenesis and Neurovascular Homeostasis
… in the adult mouse brain occurs within the subventricular zone (SVZ) of the lateral ventricle. In the SVZ, neural stem cells (NSC) reside in a specialized microenvironment, or vascular niche, consisting of blood vessels and their basement membranes. Most NSCs in the SVZ differentiate into …
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Death, survival, and morphological development of hippocampal granule cells born in an inflammatory environment
… to two subcompartments of the brain; the subventricular zone lining the lateral ventricles, and the subgranular zone (SGZ) in the hippocampal formation. A variety of stimuli such as voluntary exercise, epileptic seizure activity and inflammation can affect the basal level of neurogenesis. …
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Two Sides of The Same Coin in The Levodopa Treatment of Parkinson's Disease
… on NPCs in isolated from the postnatal subventricular zone (SVZ) and in PD animal model.
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Neural Stem / Progenitor Cells in the Adult Mouse Hypothalamus
… to exist in the neurogenic regions of the subventricular zone and dentate gyrus; however there is increasing evidence to suggest that neurogenesis may also occur in other brain regions. It has been proposed that one such population of neural stem cells resides in the hypothalamus, more …
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Characterization of Normal Development and Injury in the Premature Baboon Brain
… repair by inducing proliferation of cells in the subventricular zone.
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Mash1 Defines Lineage Restricted Neuronal and Oligodendrocytic Precursor Cells in Spinal Cord Development
… of Mash1 descendents in the early postnatal subventricular zone. Using M1-CRE-ER™;R26RlacZ and M1-CRE-ER™;R26R-YFP, Mash1+ cells trace into adulthood in a temporally-dependant manner. Cells expressing Mash1 at E10.5 become neurons of the dorsal horn in lamina I-IV while cells expressing Mash1 …
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The Brain Invaders: Widespread Neuronal Dispersion in Developing and Adult Mammalian Brain
… chain migration that was first identified in the subventricular zone (SVZ) in the adult mouse brain. I developed an in vitro migration assay using Matrigel as a substrate, which allowed me to analyze dynamics and mechanism of SVZ cell translocation. I demonstrated that neurons migrating in chains …
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Cellular and Circuit Level Responses to Neural Stem Cell Transplantation in the Rodent Cortex
… signaling. Primary NSCs from the postnatal subventricular zone showed similar effects on microglial-mediated cytotoxicity. Together, these results suggest that undifferentiated NSCs possess an inherent capacity to modulate microglial functions which can affect neuronal survivability and …
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Regulation of Adult Neurogenesis by the ERK5 MAPK Signaling Pathway and its Functional Implications in Learning and Memory as well as Olfaction
… in the adult mammalian brain, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) along the lateral ventricles. External stimuli including environmental enrichment activities and olfactory stimulation induce adult neurogenesis. Thus, adult neurogenesis may play an …
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