Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"subunit vaccines"”.
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Controlled release microneedle technologies for the enhanced immunogenicity of subunit vaccines
The poor efficacy of subunit protein vaccines, which typically consist of a protein antigen and a molecular adjuvant, has recently been improved by completing multiple injections of the vaccine with an exponential dosing profile over time. The hypothesis is that as viruses replicate in a host …
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Development of subunit vaccines against porcine reproductive and respiratory syndrome virus (PRRSV)
… US dollars every year. Modified-live PRRSV vaccines (MLV) are the most effective option currently available for the control of the disease. MLVs can confer solid protection against homologous re-infection and have significant effects in reducing viral shedding. But the vaccine efficacy …
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An integrated approach to enable rapid scalable upstream production of subunit vaccines with Pichia pastoris (Komagataella phaffii)
… countries (LMICs). Due to limited supply, vaccines targeting SARS-CoV-2 were initially distributed primarily to high-income countries. The distribution of vaccines which were eventually made available to LMICs was complicated by logistical challenges such as the need to maintain cold-chain …
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Nanoscale antigen organization regulates binding to specific B-cells and B-cell activation
The successes of vaccines in modern medicine diminished the morbidity and mortality of many pathogenic infections. Yet, difficulties remain in improving the immunogenicity of modern subunit vaccines. In addition, isolation of antigen-specific memory B cells that would elucidate the long-term …
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Engineering translational vaccine delivery systems with the polyphenol tannic acid
… for local drug delivery to dendritic cell (DC) vaccines termed META (Membrane Engineering using Tannic Acid). DC vaccines hold great potential for a spectrum of diseases including cancer and autoimmune conditions, and combination drug delivery is an attractive strategy to manipulate their …
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Plant-produced, trans-encapsidated, replicative viral nanoparticles as a vaccine platform.
Replicative virus-based vaccines provide potential solutions to avoid the natural deficits of traditional single-protein subunit vaccines. Unlike subunit vaccines, the infectious nature of viral particles can stimulate the innate immune response, which allows enhanced and elongated stimulation of …
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DNA-Launched Vaccines for Emerging and Re-emerging Viral Pathogens
… the availability, consistency, and production of vaccines. Although there are approved vaccines for some of these diseases there are still issues that face the implementation of these vaccines is susceptible populations in endemic areas. To address these issues, it was necessary to develop and …
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Product and host engineering for low-cost manufacturing of therapeutic proteins in the yeast Komagataella phaffii
… biologic medicines such as prophylactic vaccines and monoclonal antibodies, particularly in low- and middle-income countries (LMICs). Therapeutic proteins, which can be stored as liquids, are more amenable to distribution in LMICs than newer modalities like therapeutic RNAs that require …
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Enterotoxin B Subunit Lectins as Adjuvants for Improvement of Mucosal Vaccine
<p>In comparison with whole organism vaccines, subunit vaccines may be safer for immunization but may lack sufficient immunogenicity to provide complete immunity to the pathogen. To resolve this problem, bacterial and plant enterotoxin B subunit adjuvants containing a variety of receptor-binding …
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Virus-like particles as a vaccine against porcine reproductive and respiratory syndrome virus
… worldwide. Several inactivated and modified live vaccines (MLV) have been developed to curb PRRSV infections. The unsatisfactory efficacy and safety of these vaccines, drives for the development of new generation PRRS universal vaccines. Virus like particles (VLPs) based vaccines are gaining …
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Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
… against intracellular pathogens and cancer.Vaccines that elicit robust CD8+ T cell responses are desirable for protection against such infectious diseases and cancers. Subunit vaccines using whole protein or peptide epitopes are becoming increasingly favored due to their superior safety …
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The delivery of bioactive proteins using biodegradable microspheres
… mainly BSA, tetanus toxoid, F1 and V, Y. pestis subunit vaccines and the cytokine, interferon-gamma. The polymer chosen for use in the vaccine preparation will directly determine the characteristics of the formulation. Full in vitro analysis of the preparations was carried out, including surface …
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Statistical modelling to determine the influence of vaccine dose and prior Mycobacterium tuberculosis exposure on antigen-specific T cell responses
This dissertation investigates the effects of two subunit vaccines H1:IC31 and H56:IC31 as well as prior M.tb sensitization on the immune responses of three cohorts of South African adolescents and adults. The primary outcomes are frequencies of antigen-specific CD4 T cells expressing different …
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HIV-1 Immune Escape and Neutralizing Antibodies : Solid Phase Proteoliposomes Containing HIV-1 Envelope Glycoproteins as Antigens and Immunogens and HIV-1 Core Envelope Glycoproteins Deficient in T-Helper Epitopes
… The design of envelope glycoprotein-based subunit vaccines has been frustrated by many viral immune escape mechanisms. Trimeric envelope glycoprotein formulations hold promise to overcome limitations of monomeric envelope glycoproteins as immunogens. The generation of native, trimeric …
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Engineered microneedles for transcutaneous vaccine delivery
… strategies for the noninvasive delivery of subunit vaccines to the skin. We have utilized laser ablative micro-molding of poly(dimethylsiloxane) to generate bio resorbable poly(lactide-co-glycolide) micro-structured skin patches bearing -100 micron-scale needles arrayed across their surface. …
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Identifying B-cell epitopes of African horse sickness virus serotype 4 recognised by antisera of immunised horses
… fears of reversal to virulence. Inactivated and subunit vaccines have been tested but are not commercially available. Research towards recombinant vaccines that will offer protection without these limitations is thus ongoing. Identification and characterisation of antigenic regions on proteins …
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… Previous studies have shown that glycoconjugate vaccines can provide enhanced protection against lethal B. pseudomallei challenge. However, the limited pool of Burkholderia antigens hinders continued optimization of these vaccines. In this study, we used a reverse vaccinology approach to identify …
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… Previous studies have shown that glycoconjugate vaccines can provide enhanced protection against lethal B. pseudomallei challenge. However, the limited pool of Burkholderia antigens hinders continued optimization of these vaccines. In this study, we used a reverse vaccinology approach to identify …
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Investigations Into a Rationally Designed Modified Live Vaccine for Equine Strangles
… difficult. Currently available modified live vaccines lack safety and, to date, subunit vaccines have been ineffective in preventing experimental challenge. The goal of this work is the development of a gene deletion mutant vaccine which would be not only safe and efficacious but readily …
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The Development of an African Horse Sickness Virus VP7 Quasi-Crystal Vaccine Candidate in N. benthamiana
… AHS and the commercially used live-attenuated vaccines (LAVs) have various side effects. Insoluble particulates have been shown to increase immunogenicity when compared to soluble subunit vaccines and previous studies demonstrated protection of BALB/c mice immunised with African horse sickness …
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