Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"subunit vaccine"”.
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A Multiepitope Subunit Vaccine for Enterotoxigenic Escherichia Coli (ETEC) Expressing LT, STA, STB, and STX2E Toxins
… worldwide. Currently, there is no effective vaccine to protect young animals, such as pigs, against ETEC diarrhea. Enterotoxins, including heat-labile (LT), heat-stable type I (STa), heat-stable type II (STb) and shiga-like toxin Stx2e, produced by ETEC strains are the virulence determinants …
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Development of a Subunit Vaccine Against Bovine Diarrhea Caused by K99 Enterotoxigenic Escherichia coli and Bovine Viral Diarrhea Virus
… and other illness to cattle at all ages. A vaccine that prevents against both K99 fimbrial ETEC and BVDV could benefit greatly to cattle producers worldwide. We hypothesized that a novel multivalent vaccine composed of K99, STa and BVDV E2 antigens could induce immunity for broad protection …
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Development and characterization of Shigella multiepitope fusion antigen (MEFA) for a broadly protective subunit vaccine against shigellosis with extended utility against enterotoxigenic Escherichia coli.
… and with increasing multidrug resistance. Vaccines represent a significant preventive measure against infectious diseases; however, no approved vaccines are currently available to protect against Shigella spp. A critical challenge in developing vaccines for Shigella lies in achieving …
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Development of subunit vaccines against porcine reproductive and respiratory syndrome virus (PRRSV)
… US dollars every year. Modified-live PRRSV vaccines (MLV) are the most effective option currently available for the control of the disease. MLVs can confer solid protection against homologous re-infection and have significant effects in reducing viral shedding. But the vaccine efficacy …
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Utilization of Cholera Toxin B as an Adjuvant for the Subunit PspA Vaccine, Provides Effective Protection against Streptococcus pneumoniae Challenge
… most serotypes and a potential candidate as a subunit vaccine against <em>Streptococcus pneumoniae. </em>To increase the immunogenicity of PspA for long term and effective protection, this study utilizes Cholera Toxin B (CTB) as an adjuvant to effectively increase vaccine efficacy. We assessed …
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Universal room-temperature stable influenza A nanovaccine
… threat, the development of a universal IAV vaccine is paramount to global public health. The work described herein forms the basis of a universal IAV subunit nanovaccine formulation composed of a novel equine IAV antigen and IAV nucleoprotein delivered via polyanhydride nanoparticles and …
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DNA-Launched Vaccines for Emerging and Re-emerging Viral Pathogens
… the availability, consistency, and production of vaccines. Although there are approved vaccines for some of these diseases there are still issues that face the implementation of these vaccines is susceptible populations in endemic areas. To address these issues, it was necessary to develop and …
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Product and host engineering for low-cost manufacturing of therapeutic proteins in the yeast Komagataella phaffii
… biologic medicines such as prophylactic vaccines and monoclonal antibodies, particularly in low- and middle-income countries (LMICs). Therapeutic proteins, which can be stored as liquids, are more amenable to distribution in LMICs than newer modalities like therapeutic RNAs that require …
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DEVELOPMENT OF A VACCINE FOR LYME DISEASE USING THE NUCLEOSIDE-MODIFIED mRNA-LNP PLATFORM
… disease in the United States, in part because a vaccine against it is not currently available for humans. We propose utilizing the lipid nanoparticle-encapsulated nucleoside-modified mRNA (mRNA-LNP) platform to generate a Lyme disease vaccine like the successful clinical vaccines against …
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Synthesis of a hydrogel-based vaccine to mimic dendritic cell responses to pathogens
… pathogens are the basis of many successful vaccines due in part to the orchestrated response of dendritic cells (DCs) triggered by these immunizations, which includes (1) DC and DC precursor attraction to the immunization site, (2) efficient antigen delivery to class I and class II MHC …
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Beak and feather disease virus candidate vaccine development
… psittacine species. There is currently no vaccine against BFDV and safe and affordable vaccine candidates are needed to alleviate the disease burden caused by this virus. Production of the BFDV's major antigenic determinant, the capsid protein (CP), in the inexpensive and highly scalable …
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B CELL EPITOPE MAPPING OF RIVAX, A CANDIDATE RICIN VACCINE ANTIGEN
Ricin toxin’s enzymatic A subunit (RTA) is a 267 amino acid RNA N-glycosidase that depurinates a conserved adenine residue of 28S rRNA, resulting in ribosome arrest and apoptosis. One of the leading subunit vaccine candidates for ricin is RiVax, a two point mutant (V76M, Y80A) of RTA. RiVax has …
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Purification of the major envelope protein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) from native virions
… swine industry for more than twenty years. PRRSV vaccine development is challenging due to virus heterogeneity. Evidence indicates that the major envelope protein, GP5, is the primary target for a subunit vaccine. In native virions GP5 primarily exists as a disulfide linked complex with the …
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Elucidation of antigenic epitopes on the rubella virus E1 glycoprotein
… of the defined epitopes in the development of subunit vaccine is discussed.
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Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii
… we improved the desired glycan abundance on a subunit vaccine candidate. The process-robustness of engineered strains suggests the potential of this host as a viable commercial biomanufacturing host.
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Multi-criteria Decision Analysis (MCDA) Interventions on Reducing Campylobacter jejuni Contaminations on Processed Chicken
… the current developmental stage of Campylobacter vaccines rather than their long-term potential. Unlike other interventions that are already commercially available or widely implemented, vaccination strategies remain under investigation, with promising advances in both live-attenuated and subunit …
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The development of novel diagnostic countermeasures for Rift Valley fever virus
… renewed interest in developing diagnostics and vaccines to protect both agriculture and public health. Having specific and versatile diagnostics is critical for vaccine development and application. For example, diagnostic tools that aid in identifying key immunogens and understanding the …
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Immunocontraceptive vaccines against brucellosis and population growth in feral swine
… hormone (mGnRH) has been previously used as a subunit vaccine to induce immunocontraception in feral pigs. However, potent adjuvants and large amounts of purified antigen are needed to elicit a robust anti-GnRH immune response and current delivery methods are limited. Brucella suis strain VTRS2 …
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Estradiol and MDMA affect the susceptibility and immune response to genital herpes and genital herpes immunization
… virus during sexual contact, thus a prophylactic vaccine is needed. Therefore, the research presented here examines a factor that could be important in enhancing susceptibility to genital herpes disease as well as one that could be important in enhancing vaccine-afforded protection against it. …
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Plant-based Multicomponent Vaccines against Enteric Diseases
<p>To generate a plant-based multicomponent oral vaccine against cholera, rotavirus and enterotoxigenic E.coli (ETEC), we have constructed transgenic potato plants that synthesize the cholera toxin B and A2 subunits, the rotavirus enterotoxin NSP4 22 amino acid epitope and the ETEC fimbrial antigen …
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