Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 791 for “"subtype"”.
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Estrogen Receptor Subtype Selective Ligands
… of non-steroidal ligands that show pronounced subtype-selective differences in ligand binding and transactivation potency or efficacy, the study of the structure-function relationships, and the molecular basis for the subtype-selective action. A …
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The role of HIV-1 subtype B Envelope transmission motifs in subtype C variant infectivity
… genital tract. One study compared over 5000 subtype B TF and mismatched chronic infection envelope (env) sequences and identified two putative transmission motifs: Histidine at position 12 of the signal peptide (His12) and a potential N-glycan site (PNG) at position 413-415. Although, His12 …
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Nonconstituent coordination as a subtype of constituent coordination
This dissertation provides an account of NCC (Non-Constituent Coordination) in HPSG, based on the hypothesis that all coordination is coordination among the same types of daughters.
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Cortical Pyramidal Neuron Subtype Classification and Visual Response Diversity
… of pyramidal neurons into functional subtypes remains a crucial part of this survey since the subtype-specific division of labor creates a rich substrate for computation. However, the extreme integration of individual neurons into the collective cortex suggests that cellular …
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Genetic Control Of Enteric Nervous System Development And Subtype Specification
… are present but dysfunctional, or if neuron subtypes are incorrectly specified. Unfortunately, the transcriptional machinery underlying neuron subtype identity in the ENS is poorly understood, and we also know little about genetic causes of dysfunctional motility in CIPO and post-surgical …
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Define The Epigenetic Profiles and Subtype-Specific Genes of Breast Cancer
<p>Molecular profiling has identified 5 distinct subtypes of breast cancer, luminal A, luminal B, HER2-enriched, basal-like, and claudin-low breast cancer. These 5 subtypes correlate with hormone response, patient prognosis, and response to therapy. Although steady state gene expression patterns …
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Paradoxical Insomnia, a Chronic Insomnia Subtype in Patients with Temporomandibular Disorder
… These findings point to a chronic insomnia subtype called paradoxical insomnia, where individuals may mistake their sleep for wakefulness and a bidirectional link between subjective daytime function and sleep. Future studies should further examine the effect of cognitive behavioral therapy …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
Neuroinflammation is becoming increasingly recognised as key to the pathogenesis of Alzheimer’s disease and tauopthies. Epidemiological studies report a delay in the onset of Alzheimer’s in subjects using nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit enzymes in the cyclooxygenase-2 …
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Neuropsychological Comparisons Of Obsessive-Compulsive Disorder Subtype And Body Dysmorphic Disorder Symptomatology
<p>Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD) are often severe and disabling psychiatric conditions. Although BDD is currently regarded as a somatoform disorder in the DSM-IV, it has been suggested that it would be better classified as being part of an …
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Novel Core Scaffolds for the Development of Subtype Selective Estrogen Receptor Ligands
… heterocyclic and acyclic, in our search for subtype selective ligands. During our studies we discovered ligands containing new pharmacological profiles for estrogens. The pyrazolo[1,5-a]pyrimidine ligands provided us with two new pharmacological classes of ligands: (1) ERbeta potency …
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The Influence of HIV-1 Subtype C LTR Genotype on Latency Potential
… lead to HIV-1 remission in infected individuals. Subtype level genotypic variation within regulatory elements of the HIV-1 promoter, the long terminal repeat (LTR), has been shown to influence latency establishment in in vitro models. We investigated the influence of inter-participant subtype C …
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An investigation into improved HIV-1 subtype C envelope based vaccine design
Includes abstract. Includes bibliographical references.
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Does phonological processing, a specific subtype of dyslexia, impact performance on intelligence tests?
… study was to examine the impact of a specific subtype of dyslexia, namely phonological processing, on performance and the results of ability on IQ testing. Twenty-two records from a learning center in southern New Jersey were used for data in this study. The sample consisted of 12 male and 10 …
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Defining and Controlling the Subtype Identity of Human Stem Cell-Derived Motor Neurons
… to disease. We therefore set out to define the subtypes of human motor neurons in vivo and to generate these in vitro. Here we report that human motor neurons in vivo share with mouse the molecular markers of motor neuron column, division, and pool organization, as well as positional expression …
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The Development of Novel Non -Steroidal Subtype Selective Ligands for the Estrogen Receptor
A series of furan analogs were prepared bearing basic side-chains in the hope to impart anti-estrogenic activity to this class of ligands. The basic side-chain furan analogs were also ER-alpha binding selective ligands (2--47 fold selectivity) and transcriptional assays have shown one particular …
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Investigating the transcription factor landscape of the squamous subtype of pancreatic ductal adenocarcinoma
… can be stratified into two distinct molecular subtypes: classical and squamous, with the latter being associated with poorer clinical outcome. The Carroll Lab is interested in the role of pioneer transcription factors and their chromatin associated interaction partners in regulating …
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Characterisation of HIV-1 subtype C envelope functional determinants of dual infected individuals
Identification of HIV-1 Envelope (Env) fitness determinants could provide functionally constrained, accessible regions that could be included in subunit vaccines to induce broadly neutralising antibodies (bnAb). We hypothesised that Env fitness determinants are common to circulating variants but …
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Genetic and immunological characterization of new subtype G envelope expressing HIV-1 pseudoviruses
… the genetic diversity of envelope genes of subtype G and the neutralization antibody responses to these viruses. HIV-1 subtype G accounts for 5% of HIV-1 infection worldwide, centered on West Africa, with spread to European countries, primarily Spain and Portugal, presumably with immigration …
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