Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"subthalamic nucleus (STN)"”.
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The Effects of Deep Brain Stimulation on the Speech of Patients with Parkinson's Disease
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has received more attention in recent years as a treatment option for regulating the symptoms of Parkinson's disease. Previous studies of DBS documented consistent improvements in motor function but more variability in speech outcomes. …
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Understanding Autonomic Control via Human Deep Brain Stimulation
… field potentials (LFPs)) to assess whether a nucleus is integral to a specific change in autonomic output. The sum of my work outlined in this thesis demonstrates that common DBS targets such as subthalamic nucleus (STN) and pedunculopontine nucleus (PPN) alter both cardiovascular and …
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Role of the Subthalamic Nucleus in the Circuitry Mediating Food- and Cocaine-Seeking Behavior
The subthalamic nucleus (STN) is part of the basal ganglia, which play a crucial role in motor control and in processing information from motor cortical areas. Although the STN is classically considered a motor structure, recent studies suggest that it may also be involved in the motivation for …
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Simultaneous Behavior Onset Detection and Task Classification for Patients with Parkinson Disease Using Subthalamic Nucleus Local Field Potentials
… on recorded Local Field Potentials (LFP) of the Subthalamic nucleus (STN), captured through Deep Brain Stimulation (DBS) process.</p> <p>One main part of this work is dedicated to the research of various properties and features of the STN LFP signals of several patients' behavior conditions. …
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Adaptive Detection of Beta Bursts of Local Field Potentials Recorded from Subthalamic Nucleus in Patients with Parkinson’s Disease
… leads placed into the motor territory of the subthalamic nucleus (STN) can be used to investigate the mechanism of PD and allows for further development of new therapeutic strategies. Beta band activity, which typically presents itself as bursts, has been continuously found in the LFP …
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Investigation of Spatio-Spectral Dynamics of Local Field Potentials in Parkinson’s Disease
… deficits. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has emerged as an effective neurosurgical treatment for the patients with PD where their motor symptoms cannot be controlled with medications. Accurate localization of STN is an important factor defining the efficacy of …
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Cortical - Basal Ganglia Circuits: Control of Behaviour and Alcohol Misuse
… circuitry can be subject to filtering by the subthalamic nucleus (STN), which receives direct projections from the cortex. This work first demonstrated the functional organisation of segregated intrinsic cortical – basal ganglia circuits in humans, alongside a detailed map of functional …
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Towards Closed-Loop Deep Brain Stimulation: Behavior Recognition from Human STN
… signals can be used to recognize the behaviors. Subthalamic Nucleus (STN) Local field Potential (LFP) is a great candidate signal for the neural feedback, because it can be recorded from the stimulation lead and does not require additional sensors. This thesis proposes novel detection and …
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Effect of dopamine on synchronous neuronal oscillations in the globus pallidus-subthalamic nucleus network
… Parkinson’s disease. The globus pallidus (GP) – subthalamic nucleus (STN) network has been proposed to form a pacemaker driving regenerative synchronous bursting activity. In order to test whether this activity can be sustained in vitro a 20o parasagittal slice of mouse midbrain was developed …
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Dissection of Neurons and Circuits Involved in Regulating Innate Behaviors, Movement and Higher Cognitive Functions in Mice
… ganglia, and in particular on the role of the Subthalamic Nucleus (STN) in Parkinson's Disease and Obsessive-Compulsive Disorder. I identified previously undescribed subpopulations of STN neurons, and tested their role in mediating motor, emotional and cognitive functions in mice, both in …
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Mechanisms of Deep Brain Stimulation for the Treatment of Parkinson's Disease: Evidence from Experimental and Computational Studies
… the mechanisms underlying the effectiveness of subthalamic nucleus (STN) DBS by quantifying changes in neuronal activity in the basal ganglia during both effective and ineffective DBS.</p><p>Two different approaches were adopted in this study. The first approach was the unilateral …
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Anatomical and Physiological Characterization of Striatal Activation of the Cerebral Cortex
… external seg-ment of globus pallidus (GPe), subthalamic nucleus (STN), and substantia nigra pars retic-ulata (SNr) by c-Fos immunostaining at baseline and upon activation by treatments with L-dopa and DA agonists, separately. Third, in vivo unit spike recording was used to monitor the spike …