Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"substrate oxidation"”.
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Electrochemical and Photocatalytic Flow Strategies for Sustainable Substrate Oxidation
… flow. An investigation into the aerobic oxidation of a variety of organic substrates was made, and a comparison between the performance of batch and flow CNx photoreactors was conducted. Design of the initial flow prototype involved some computational fluid dynamics analysis and was based …
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Bacterial Cyanide Assimilation: Pterin Cofactor and Enzymatic Requirements for Substrate Oxidation
… the latter satisfying the nitrogen requirement. Substrate attack is initiated oxygenolytically by an enzyme referred to as cyanide oxygenase (CNO), which exhibits properties of a pterin-dependent hydroxylase. The pterin requirement for Pf11764 CNO was satisfied by supplying either the fully …
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The Effect of a Probiotic Supplement on Insulin Sensitivity and Skeletal Muscle Substrate Oxidation during High Fat Feeding
… on body weightand composition, skeletal muscle substrate oxidation, and insulin sensitivity and during 4 weeks of high-fat, hypercaloric feeding. We hypothesized that the probiotic would attenuate the body weight and fat gain and adverse changes in insulin sensitivity and substrate oxidation …
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The effects of omega-3 supplementation on whole body and skeletal muscle energy metabolism in humans
… resting metabolic rate (RMR) and fatty acid (FA) oxidation is limited and controversial. In the first study of this thesis, supplementing with a high dose of fish oil (FO) containing 2 g/d eicosapentaenoic acid (EPA) and 1 g/d docosahexaenoic acid (DHA) for 12 weeks, in healthy young males did not …
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Skeletal Muscle Substrate Metabolism following a High Fat Diet in Sedentary and Endurance Trained Males
… is characterized by the resistance to switching substrate oxidation preference based on substrate availability and can be measured in either fasted or insulin-stimulated conditions. As the largest site for glucose disposal and a primary tissue influencing regulation of blood glucose …
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The effects of prolonged standing compared to prolonged sitting on postprandial lipemia
… was used to measure metabolic rate and substrate oxidation while spectrophotometry was used to measure plasma concentration. Area under the curve (AUC) for the postprandial responses in plasma glucose and triglyceride were calculated with the trapezoidal rule. Prolonged standing resulted …
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The effects of fluctuations in oestrogen and progesterone during the menstrual cycle on glucose homeostasis, energy balance, exercise and premenstrual syndrome
… and insulin response, energy expenditure, substrate oxidation and premenstrual syndrome (PMS). The aim of the first study was to investigate glucose and insulin responses to a 75g glucose load during different phases of the menstrual cycle. Venous blood samples for baseline measurements of …
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Systems biology approach to understanding the control of glucose metabolism in healthy and apoptotic neurons
… of glucose uptake, glycolysis, mitochondrial substrate oxidation and mitochondrial phosphorylation. Kinetic stimulation of the oxidative pentose phosphate pathway by apoptosis was a major contributor to the decrease in glycolysis, while kinetic inhibition of mitochondrial phosphorylation was a …
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Oxidation of substrates tethered to N-donor ligands for modeling non-heme diiron enzyme active sites
… of biological systems to activate dioxygen for substrate oxidation, and small molecule models have been synthesized to mimic this chemistry outside of the natural systems. In this introductory chapter a brief overview of terphenyl-based carboxylate systems is given and progress toward achieving …
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Skeletal muscle metabolic adaptations in response to an acute high fat diet
… and balanced. Further, when analyzing the oxidation of carbohydrate and fat in the skeletal muscle specifically, carbohydrate balance happens quite rapidly, while fat balance does not. The ability of skeletal muscle to adapt and respond to various nutrient states is critical to maintaining …
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Perfusion Solution Optimization by Substrate Alteration and Nanoparticle Delivery for Cardiac Hypothermic Machine Perfusion
… of this study was to 1) Determine myocardial substrate preferences during HMP 2) Evaluate the effect of metformin and insulin on substrate oxidation in the perfused heart 3) Demonstrate delivery of nanoparticles to the heart during HMP. In Aim 1, I investigated myocardial substrate selection …
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Pharmacokinetics and effect of pioglitazone in obese, insulin-resistant cats
… any species-specific effects of pioglitazone on substrate oxidation or energy expenditure. Third, 1H magnetic resonance spectroscopy (1H MRS) was performed to determine hepatic fat content in the 12 obese cats and in 6 lean cats using a modification of established human methods, and fat content …
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A metabolic profiling approach to human disorders of energy metabolism
… of human mitochondrial disease that reflects substrate oxidation, biosynthesis and energy charge.
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The Relationships of Age, Physical Activity Level, Adiposity, and Diet, with Human Satellite Myogenesis, and Metabolism
… Cells were also subjected to an in-vitro, high substrate media (HSM) challenge, then grown in media with a fivefold increase in glucose (25 mM) and an additional 400 uM of fatty acids (2:1 palmitate:oleate) before seven days of serum starved differentiation. The cells were evaluated for their …
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Modeling the active sites of diiron and dicopper metalloproteins with napthyridine-, phthalazine-, and diethynylbenzene-based ligands
… carboxylate-bridged diiron centers to achieve substrate oxidation using dioxygen, and numerous small molecule model compounds have been synthesized in order to mimic this chemistry in the absence of a protein scaffold. In this introductory chapter, a brief overview is presented of ligand …
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Increased fat oxidation in 3T3-L1 adipocytes through forced expression of UCP 1
… novel respiratory uncoupling protein to increase substrate oxidation, and thereby control adipocyte fatty acid content. Increasing molecular evidence points to a family of uncoupling proteins (UCPs) playing an important role in adipocyte fat metabolism. Of specific interest is UCP1, which in brown …
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Gut-brain interactions in food reward
… to assess post-consumption changes in substrate oxidation rates. At the post-testing session, changes in self-reported liking, wanting, and ad libitum intake of each beverage are recorded. Brain response to each flavor cue (without calories) is measured using fMRI at the post-test. We …
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The impact of carbohydrate ingestion on the regulation of fat oxidation following exercise
… (CHO)ingestion on the regulation of fat oxidation following glycogen lowering exercise. Methods: Six males (age 23.4 2 1.7y, vo2peak 58.0 2 2.1 ml.kg-'.min-') participated in the study. Subjects performed an incremental maximal cycle ergometer test and a verification trial to determine …
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The effect of circadian regulation and sleep disruption on metabolic homeostasis
… was to determine the circadian rhythms of substrate oxidation and hormonal regulators of energy balance as well as to identify molecular alterations associated with insufficient sleep, including skeletal muscle lipid accumulation and altered gene expression, and their relation with insulin …
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