Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"substrate metabolism"”.
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Substrate metabolism and acid secretion in the rat stomach
… aim of this work was, firstly, to identify which substrates could support acid secretion by rat parietal cells and secondly, to investigate the intracellular events involved in stimulus transduction in rat parietal cells. A technique was developed which enabled satisfactory measurements of …
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The effect of muscle glycogen status on control of substrate metabolism during exercise
Glycogen depletion has frequently been shown to result in a decrease in respiratory exchange ratio (RER). However, the metabolic response to glycogen depletion has generally been studied in overnight fasted subjects or in subjects who were already fatigued, or hypoglycaemic, or both, raising the …
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The role of brown adipose tissue on substrate metabolism and insulin sensitivity in humans
… of genes involved in thermogenesis and lipid metabolism in BAT. The newly established BAT biopsy technique was safe and well tolerated. These results demonstrate a physiologically significant role of BAT in whole-body energy expenditure, glucose and lipid homeostasis, insulin sensitivity, and …
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Skeletal Muscle Substrate Metabolism following a High Fat Diet in Sedentary and Endurance Trained Males
… is characterized by the resistance to switching substrate oxidation preference based on substrate availability and can be measured in either fasted or insulin-stimulated conditions. As the largest site for glucose disposal and a primary tissue influencing regulation of blood glucose …
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The linking of angiogenesis to contractile performance and substrate metabolism in the hypertrophied and failing heart
… capillarity affect contractile performance and substrate metabolism in the isolated rat heart. It was hypothesised that, if cardiac contractile performance and substrate utilisation are directly related to ventricular capillarity then methods to alter the number and distribution of capillaries …
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The Role of Fatty Acids on Toll-like Receptor 4 Regulation of Substrate Metabolism with Obesity
… (LPS), ex vivo, results in a shift in substrate metabolism favoring glucose as an energy substrate and preferential storage of FA in intracellular lipid depots. The purpose of this study was to examine the effects of saturated vs. monounsaturated FA on TLR4 transcription and signaling …
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Regulation of Substrate Metabolism and Renin-Angiotensin System with Dietary and Pharmacological Interventions: Implications for Obesity and Related Disorders
… the ketogenic diet (KD) on adipose tissue (AT) metabolism and renin-angiotensin system (RAS) function and potential implications for other tissues, including lung, heart and skeletal muscle. In the first study, it was demonstrated that despite increasing fat mass, a KD enhanced …
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Characterization of an in vitro exercise model and the effects of a metabolic endotoxemia on skeletal muscle adaptation to electric pulse stimulation
… of myokines and the subsequent increase in substrate metabolism. This study aimed to define a culture model for simulating exercise in human primary skeletal muscle cells. We hypothesized that chronic electric pulse stimulation (EPS) of human myotubes in vitro would emulate cellular and …
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Molecular and Cellular Signaling Mechanisms Elucidating Aldose Reductase Mediated Ischemia-Reperfusion Injury in the Myocardium
… syndromes, the mechanisms of normal myocardial substrate metabolism, and how metabolism is altered under ischemic conditions. Specific chapters in this dissertation aim to elucidate whether AR pathway mediated I/R injury is linked to changes in glycogen synthase kinase 3β (GSK3β) …
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Modelling an SBR waste treatment system.
… are involving expressions for SMP formed from substrate metabolism and released from activated sludge decay and classifying different basic chemical oxygen demand (COD) categories based on their biodegradabilities. In the new SBR model, total COD is divided into two parts: soluble and …
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Skeletal Muscle Adaption to 5 days of High-Fat Feeding in Humans
… muscle is highly involved in macronutrient metabolism. To maintain proper energy metabolism and physiology, skeletal muscle must adapt to nutrient supply. Thus, diet macronutrient composition is an important modulator of skeletal muscle metabolism. Evidence from rodent and human models show …
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Studies on the mode of action of the pyrithione biocides
… low levels of pyrithione induced inhibition of substrate metabolism for several substrates in both <i>E. coli</i> and <i>P. aeruginosa</i>. The most sensitive metabolism towards the pyrithiones was that for thymidine, which exhibited inhibition to about 30% of the rate of metabolism in the …
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The role of supplementary calcium in submaximal exercise and endurance performance.
… endurance exercise via studying its influence on substrate metabolism and body composition. Study 1 examined the effects of four weeks of calcium (citrate) supplementation (1000 mg elemental calcium/day) on 60 minutes of cycling at a submaximal intensity of 50%Wpeak. The results of this study …
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Bioenergetic and Metabolic Signatures of Maternal Overnutrition in the Offspring Heart
… in mitochondrial respiratory function, substrate metabolism and oxidative stress have been implicated in offspring cardiac alterations, however these bioenergetic and metabolic phenotypes remain poorly defined. This thesis aimed to investigate cardiac mitochondrial bioenergetics and …
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Skeletal muscle metabolic adaptations in response to an acute high fat diet
Macronutrient metabolism plays an essential role in the overall health of an individual. Depending on a number of variables, for example, diet, fitness level, or metabolic disease state, protein, carbohydrate and fat have varying capacities to be oxidized and balanced. Further, when analyzing the …
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ΛΕΙΤΟΥΡΓΙΚΟΤΗΤΑ ΤΟΥ ΑΓΓΕΙΑΚΟΥ ΠΝΕΥΜΟΝΙΚΟΥ ΕΝΔΟΘΗΛΙΟΥ, IN VIVO, ΥΠΟ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΣΥΝΘΗΚΕΣ
… INCREASING AMAX/KM OR BMAX VALUES FOR ALL SUBSTRATES AND INHIBITOR, RESPECTIVELY, FOR BOTH ACE AND NCT, INCONTROL AND IRRADIATED ANIMALS. 2) IONIZING RADIATION TO THE CHEST PRODUCED ENDOTHELIAL ECTOENZYME DYSFUNCTION, AS REFLECTED IN THE ALTERED ENZYME KINETICS AND SUBSTRATE METABOLISM, …
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An investigation of substrate removal and storage in the activated sludge process
… concentration of microorganisms would have on substrate removal, microbial substrate storage, and oxygen utilization at a constant food-to-microorganism ratio. Batch experiments were conducted, under aerated and completely mixed conditions, using a domestic wastewater, a paper mill wastewater, …
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Defective branched chain amino acid catabolism impairs exercise capacity and glucose homeostasis in the mouse
… isoleucine and valine, play a central role in substrate metabolism, energetics, and protein synthesis. Although BCAA supplementation is widely used to improve exercise capacity and physical fitness, elevated levels of the BCAAs have been implicated in the development of obesity and metabolic …
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The Effects of Acute Consumption and Chronic Supplementation of Cocoa on Overweight and Obese Adults at Risk of Developing Diabetes
… and improve measures of skeletal muscle substrate flexibility in a randomized, double blinded, placebo controlled parallel group design. To test the first hypothesis, 30 overweight or obese volunteers who were at-risk for diabetes completed two meal challenges using a randomized crossover …
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Protein-protein interactions and mechanistic insights for CYP2J2 and CYP5A1
… differences with CYP2J2 in the presence of the substrates arachidonic acid (AA) and ebastine. When CYP2J2 and CPR were not allowed to pre-incubate, use of a truncated CYP2J2 without the hydrophobic N-terminus caused a 200-fold decrease in the kinetics of electron transfer. In a step towards …
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