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Showing 1 to 8 of 8 for “"substrate elasticity"”.
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Substrate elasticity regulates the biophysical properties of hematopoietic stem and progenitor cells
… al. 2009). In order to decouple the effects of substrate elasticity, ligand concentration, and dimensionality on hematopoietic stem cell (HSC) fate (quiescence, self-renewal, differentiation, mobilization, homing, and apoptosis), HSCs harvested from C57B6 mouse femurs and tibias were cultured in …
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Design of Biomembrane-Mimicking Substrates of Tunable Viscosity to Regulate Cellular Mechanoresponse
… on polymeric gels have revealed the influence of substrate elasticity on cellular shape and function, a lack of suitable substrates (i.e. with mobile cell-substrate linkers) has hindered research on the role of substrate viscosity. This work presents the successful design and characterization of …
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Investigating Mechanotransduction and Mechanosensitivity in Mammalian Cells
… sense variations in the mechanical properties (elasticity) of their microenvironment by actively probing their surroundings by utilizing specialized proteins that are involved in sensing and transmitting mechanical information. The actin cytoskeleton and myosin-II motor proteins form a …
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Cellular mechanosensitivity in vitro: cell-ECM, cell-cell, and cell-material interactions
Made available in DSpace on 2015-09-29T21:02:41Z (GMT). No. of bitstreams: 2 ALI-DISSERTATION-2015.pdf: 4946984 bytes, checksum: 649de0269d74763792c883cf2346193d (MD5) LICENSE.txt: 4215 bytes, checksum: b416febe9eaf70ac46d72a4e366da385 (MD5) Previous issue date: 2015-05-13
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Homeostatic mechanics for a synthetic cell: predictions on substrate anisotropies and cell-cell interactions
… Amongst the many degrees of freedom in question, substrate topological and mechanical properties, as well as cell seeding density, stand out as critical design parameters to ensure the correct functionality of lab generated tissues. Given all these complexities, this research field is fertile for …
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The role of tissue viscoelasticity in axon guidance during Xenopus brain development
… Slit 1 and Slit 2 as well as tissue elasticity. However, while the importance of elasticity is becoming well-accepted in the context of development, biological tissues are not purely elastic but rather exhibit time-dependent mechanical properties known as viscoelasticity. In this …
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Quantitative Measurements of Force Distribution in Single and Multi Cellular Systems
… of post arrays such as local and macroscopic substrate elasticity were investigated quantitatively. These posts were shown to be able to serve as a quantitative device measuring local forces down to the nanonewton range implied by the calibration analysis. The micro-array offers a template for …
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Engineering the micro-environment to control the fate of mammalian cells
… factors in the local micro-environment like substrate stiffness, geometry, ligand density, and topography can have strong influences on determining the fate of cells. Mammalian cells respond to this myriad of micro-environmental cues by an interplay between actomyosin based cellular …