Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"substrate competitive"”.
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Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development
… a novel mechanism of action that has been termed competitive inhibition. Simocyclinone D8 was found to inhibit the growth of both Gram-(+ve) and Gram-(–ve) organisms and also inhibit a fluoroquinolone resistant mutant of DNA gyrase. Inspired by the structure and novel mechanism of action that SD8 …
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Anti-cancer Functions and Mechanisms of a pRb2/p130 Peptide Fragment
… in Spa310, it was proven that Spa310 is a substrate for Cdk1, 2, 4 and 9. Results of kinase assays supported the inhibitory effect of Spa310 on the different Cyclin-dependent kinases was resulted from a substrate-competitive mechanism. Although the data generated from this study does not …
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Chemical Approaches to Dynein Inhibition
… my PhD. Most dynein inhibitors do not act in a substrate-competitive mechanism and I posit that this may be a consequence of the complex chemomechanical cycle of dynein, which involves allosteric communication between distinct ATPase sites. All compounds with identified sites of inhibition act …