Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"substrate RNA"”.
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Distinguishing features of guide and substrate RNA recognition by H/ACA snoRNPs
… ribonucleoproteins (snoRNPs) pseudouridylate RNA in eukaryotes and archaea. They consist of four proteins and a guide RNA. It is unclear which element of the guide RNA the H/ACA proteins recognize. By designing guide RNA variants with altered structural features, I determined that H/ACA …
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Architecture of eukaryotic mRNA 3' end processing machinery and insights into the mechanism of polyadenylation
Almost all eukaryotic messenger RNAs (mRNAs) have a polyadenosine (polyA) tail at their 3′ end that is added by a multi-protein complex known as cleavage and polyadenylation factor (CPF). CPF, along with accessory cleavage factors (CF) IA and IB, cleaves the pre-mRNA within the 3' untranslated …
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Development and Application of Mass Spectrometry Based Methodologies to Study Ubiquitin-Like Modifiers
… including modification of proteins, lipids, and tRNA. Analysis of both UBL conjugation sites and characterisation of system wide proteome responses is essential to understanding the impact UBLs have on regulating cellular systems. While mass spectrometry is a powerful analytical technique, …
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STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF ARCHAEAL BOX H/ACA RIBONUCLEOPROTEIN INVOLVED IN RIBOSOMAL RNA PSEUDOURIDYLATION
Ribosomal RNAs (rRNA) undergo several post-transcriptional modifications inside the cell. These modifications can be (1) RNA- independent (enzyme only) and (2) guide RNA-mediated. In the latter mechanism, a group of small, metabolically stable, non-coding RNAs, present as ribonucleoprotein (RNP) …