Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"substance P"”.
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Substance P And The Host Immune Response
<p>This body of work examined the mechanism by which SP regulates host immunity, specifically, its control of growth factors and TLR expression in the P. aeruginosa-infected cornea. The role of mTOR and VIP in corneal infection and inflammation also was tested.</p> <p>SP has a dual role in …
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The Role of Substance P in Opioid Induced Reward
… addiction. The pro-nociceptive neurotransmitter, Substance P (SP) and its corresponding receptor (NK₁R), are not only found on pain pathways to promote pain but also found in the ventral tegmental area associated with dopamine neurons. Studies have shown that Substance P can potentiate positive …
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The role of Substance P in chronic traumatic encephalopathy
… of potential mechanisms driving these processes. Substance P (SP) is a neuropeptide involved in the process of neurogenic inflammation, which has been shown previously to be involved in many processes within the brain following traumatic brain injury (TBI) including blood brain barrier disruption …
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The role of substance P in experimental intracerebral haemorrhage.
Background: Elevated levels of substance P (SP) have previously been found following ischaemic stroke and traumatic brain injury. Inhibiting the main SP receptor (neurokinin-1 (NK1)) reduces oedema and improves functional outcome in both settings. As this thesis details, we hypothesised that SP …
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Characterising the role of substance P in acute ischaemic stroke.
… of neurogenic inflammation and the neuropeptide, substance P (SP), in mediating the development of blood brain barrier breakdown, cerebral oedema and resultant functional deficits following stroke, using a rodent model of reversible cerebral ischaemia. The findings of this thesis demonstrate that …
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The role of Substance P and its signaling pathways in central sensitization
… phenotype, such as secondary hyperalgesia. Substance P (SP) is regarded as an important neuropeptide and mainly exists in primary afferent fibers in the superficial dorsal horn. Release of SP in the dorsal horn can be triggered in response to peripheral noxious stimuli. After release, …
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Sensory Neurons Initiate Tuft Cell-Dependent Sinonasal Allergic Inflammation via Substance P
… influx and neuropeptide release, but only Substance P (SP) adaptively increased upon repetitive allergen exposure. We found that SP not only guided tuft cell lineage commitment, but also initiated allergic inflammation. To substantiate this, we targeted the SP receptor, neurokinin 1, …
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EXPRESSION OF SUBSTANCE P IN BRAINSTEMS OF VICTIMS OF SUDDEN UNEXPLAINED PERINATAL DEATH
… the immunohistochemical expression of substance P (SP) in the brainstems of 56 subjects aged from 17 gestational weeks to 10 postnatal months, died of unknown (sudden unexplained perinatal deaths and SIDS) and known causes (controls). The goals of this study were to obtain basic …
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The Immunoexpression of Nerve Growth Factor and Substance P in human Symapthetic Ganglia
… to immunoexpression of nerve growth factor and substance P in human paravertebral sympathetic ganglia and to analyze correlation between nerve growth factor, substance P, and positive discogram. Forty-three sympathetic ganglias obtained during anterior interbody fusion of lumbar spine(performed …
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The role of substance P in cerebral edema associated with rat and human infarction and contusion
… poorly understood. Recent evidence suggests that substance P (SP) plays a role in this edema and that injured SP-containing perivascular nerve fibres are involved. A study which examined tissue obtained from rat models and human post mortem infarct and contusion tissue, demonstrated that in all …
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Characterization of Sympathetic Ganglion Sensitivity to Substance P in a Genetic and a Non-Genetic Rat Model of Hypertension.
<p>Intravenous injection of substance P (SP) stimulates sympathetic ganglia to evoke a greater increase in renal sympathetic nerve activity, heart rate (HR) and blood pressure (BP) in hypertensive than normotensive rats due to upregulation of the NK<sub>1</sub> receptor. These experiments were …
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Characterisation of substance P and transient receptor potential melastatin channel messenger RNA and protein expression in acute and chronic neurological disorders.
… demonstrated a link between the neuropeptide, substance P (SP), and the development of cerebral oedema and neurologic deficits following TBI, which are attenuated with the administration of an NK-1 (neurokinin-1, SP receptor) antagonist. In addition, studies using a rat model of PD have …
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Neurokinin-1 antagonism as a novel treatment for feline asthma : investigation of the role of substance p in airflow limitation and airway inflammation
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Feline asthma, a chronic respiratory condition, results cough and/or episodic respiratory distress induced by airway hyperresponsiveness (AHR), airway eosinophilia, and airway remodeling. Homeostasis in the lung is partially …
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The role of the lateral spinal nucleus in nociception
… although the LSN is abundant in staining for substance P, the number of LSN neurons showing immunoreactivity for the target of substance P (the NK-1 receptor) represented only one-third of all neurons at this site. However, substance P and nitric oxide synthase were associated with NK-1 …
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Hydrogen-deuterium exchange studies by mass spectrometry: A method for obtaining conformational structures of proteins in solution
… exchange at specific amide hydrogens.;Insulin, substance P and ubiquitin were used as model peptide and proteins to investigate the utility of these approaches. Bovine insulin was used to study the reduction of disulfide bonds using TECP as a reducing agent after the hydrogen isotopic reaction. …
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Olfactory ensheathing cell mediated mechanisms of neurite outgrowth and axon regeneration
… to both LP and OB OEC transplantation, whereas substance-P and tyrosine hydroxylase-positive neurons grew more extensively following OB or LP OEC transplantation, respectively. To further understand the growth of spinal cord neurons in response to OECs, a proteomic analysis of OEC secreted …
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