Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 450 for “"subpopulations"”.
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Cooperative Invasion Between Tumor Cell Subpopulations
… mechanism for breast cancer metastasis, in which subpopulations of cells can cooperate with each other as opposed to competing against each other, to invade and potentially metastasize. Future studies will focus on determining the requirements for the leader cells to induce invasion and the …
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Dopaminergic modulation of prefrontal cortex subpopulations
Despite abundant evidence that dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioral functions, the precise circuit computations remain elusive. One potentially unifying theoretical model by which dopamine can modulate functions from working memory to …
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Identifying and characterizing subpopulations in massive open online courses
… data, little has been done to identify important subpopulations and understand their strengths and weaknesses. This thesis focuses on the potential of various learner subpopulations to succeed and contribute to the course. First, I investigate teacher enrollment in 11 MITx MOOCs showing that …
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Distinct Functional Properties of Perinatal Versus Adult Adipose Progenitor Subpopulations
… lab previously identified functionally distinct subpopulations of PDGFRβ+ perivascular progenitor cells within adult WAT depots that differentially impact tissue remodeling in obesity. PDGFRb+ APCs contribute to adipocyte hyperplasia associated with diet-induced obesity, whereas PDGFRb+ …
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Characterisation of L-cell secretory mechanisms and colonic enteroendocrine cell subpopulations
… form one of two transcriptomically distinct subpopulations of L-cells in the murine colon, with the other distinguished by expression of neurotensin (Nts). Another major EEC subpopulation, enterochromaffin (EC) cells could be split into three groups, mechanosensitive and pro- inflammatory EC …
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Microfluidic differentiation of subpopulations of cells based on their bioelectrical signature
… devices were engineered for differentiation of subpopulations of cells based on their bioelectrical properties. These microdevices were utilized for separating prostate, leukemia, and three different stages of breast cancer cells from hematologic cells with concentrations as low as 1:106 with …
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ENGINEERING LIPID AND HYBRID NANOVECTORS FOR TARGETED GENE DELIVERY TO MACROPHAGE SUBPOPULATIONS
In this work, a structural taxonomy of these systems is proposed with the aim of clarifying the possible architectures that can arise when genetic materials are complexed with a polycation or a lipid, followed by the addition of a lipid or a polymer to ameliorate the cellular toxicity, modulate …
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Assessing the effects of subpopulations on the application of forensic DNA profiling.
Currently, UK forensic service providers (FSPs) tend to employ three geographically-broad databases when estimating profile frequencies based on a standard SGM Plus® DNA profile. These estimations will typically include correction factors to take into account issues such as substructuring of …
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Genetic Dispersal Patterns in Cetaceans: The Development of Dolphin, Whale, and Porpoise Subpopulations
… such as sex-biased dispersal, philopatry, and subpopulations. The papers were examined for theories behind dispersal patterns. It has been found that populations are highly subdivided in small areas, with female philopatry. Even with female philopatry, there was no sex-biased dispersal in …
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DEVELOPMENT OF A BIOINFORMATICS FRAMEWORK TO IDENTIFY CELL SUBPOPULATIONS FROM BULK TRANSCRIPTIONAL DATA
… without considering the presence of multiple subpopulations. This limitation might be extremely critical when analyzing bulk gene expression profiles of cancer samples, where dissecting the mix of cell populations could shed light on the intratumoral heterogeneity and on the molecular …
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Dividing the Preplate: Characterization of Neuronal Subpopulations in the Early Murine Cerebral Cortex
… understood, and few markers exist to identify subpopulations of the preplate. The aim of this thesis is to functionally and molecularly characterize neuronal subpopulations of the mouse preplate. Using transgenic mice expressing EGFP in distinct preplate subpopulations, I applied birthdating …
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Adaptations of skeletal muscle pyruvate dehydrogenase kinase in response to food-restriction in mitochondrial subpopulations
… subsarcolemmal (SS) and intermyofibrillar (IMF) subpopulations. SS and IMF mitochondria exhibit distinct morphological and biochemical properties; however the functional differences are not well understood. This study investigated the effect of fed (FED) versus 48 h total foodrestriction (FR) on …
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Uses of the Hypergeometric Distribution for Determining Survival or Complete Representation of Subpopulations in Sequential Sampling
<p>This thesis will explore the hypergeometric probability distribution by looking at many different aspects of the distribution. These include, and are not limited to: history and origin, derivation and elementary applications, properties, relationships to other probability models, kindred …
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Characterizing natural genetic variation in photosynthetic efficiency across 44 accessions and five subpopulations of oryza sativa
… study, 44 accessions representing all five rice subpopulations from the larger Rice Diversity Panel 1 (RDP1) were phenotyped for photosynthetic efficiency at the International Rice Research Institute (IRRI) in Los Baños, Philippines. Phenotyping of both physiological and biochemical traits …
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Conditional control of MITF reveals cellular subpopulations essential for melanoma survival and recurrence in new zebrafish models
… lineage transgenes to identify and visualize subpopulations of cells remaining at the site of regression in these new zebrafish melanoma models. I hypothesised that these are the cells of origin for tumour recurrence (melanoma stem or progenitor cells), showed that some of them express a …
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Classification of Neuronal Nicotinic Acetylcholine Receptors in Rat CA1 Hippocampal Interneuron Subpopulations Defined by Calcium-Binding Protein mRNA Expression
… This study reports that subpopulations of nAChR-containing interneurons defined by quantitative CaBP mRNA expression or CaBP+nAChR co-expression do exist within the CA1 region of the hippocampus.</p>
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PKPD-Model Based Preclinical Characterization of the Activity of Spectinamide 1599 Against Mycobacterial Subpopulations. and the Identification of Potential Partners for Combination Therapy
Tuberculosis is one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent prior to COVID19. Mycobacterium tuberculosis (Mtb) is the causative agent of TB. The interaction between Mtb and the immune system leads to development of diverse environmental …
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