Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"subnuclear localization"”.
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Identification and functional characterization of the novel MAR-binding protein, SATB2
… Interestingly, SUMO conjugation affects the subnuclear localization of SATB2 and is involved in its targeting to distinct nuclear speckles (bodies). Thus, our data indicate that the regulation of SATB2 function through sumoylation can be mediated by both altering its transcriptional …
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Ehrlichia chaffeensis TRP32 is a Nucleomodulin that Regulates Host Gene Expression and Post-Translational Modifications Determine its Localization and Function
… the HECT-ligase inhibitor, heclin, alters TRP32 subnuclear localization and impairs TRP32’s ability to repress transcription of target genes in a luciferase assay and that this can be phenocopied using K63R and K123R mutants of TRP32.
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Delineation of the molecular mechanisms underlying DNA replication initiation and changes in gene copy number during Drosophila development
… of underreplication in polytene tissues. Our ORC localization studies also suggest that underreplication zones are hard-wired across tissues and that differential underreplication of these zones is dependent upon variation in fork progression across these regions. We then utilized the Drosophila …
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Sex And Heterochromatin: An Investigation Of Sexual Dimorphism In Drosophila Melanogaster
… roX1MS2-6 was used to visualize in vivo roX1 localization in early Drosophila embryos, but subnuclear localization was only detectable on the X chromosome of males after the onset of dosage compensation (3hr AEL).</p> <p> I then performed genetic screens to determine the signal that dictates …
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A Cell Biological Determination of Integrator Subunit Localization
… of the Integrator subunits would exhibit nuclear localization, but the knowledge of discrete subnuclear localization (i.e. to Cajal bodies) of any of the subunits could provide important clues to the function of that subunit. In this study, we used a cell biological approach to determine the …
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The Nuclear Pore Complex: Novel Glycoprotein Constituents
… and Golgi complex. I have also investigated the subnuclear location of some of the other GlcNAc containing proteins. Using wheat germ agglutinin, as well as another mAb with broad specificity for nuclear GlcNAc-containing proteins, I show by immunofluorescence and protein blotting of subnuclear …
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Nova Regulation of Alternative Splicing in the CNS
… Also, Nova proteins localize to distinct subnuclear foci, but fail to co-localize with a number known proteins that occupy sub-nuclear structural domains. Unlike nuclear speckles, which contain a number of other splicing factors, Nova foci are disrupted by treatment the cells with …
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The Function and Regulation of Photobodies in Phytochrome Signaling
… cytoplasm to the nucleus, where they localize to subnuclear foci termed photobodies; in continuous light, photobody localization correlates closely with the light-dependent inhibition of embryonic stem growth. Despite a growing body of evidence supporting the biological significance of photobodies …