Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"subgranular zone"”.
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Novel Astrocyte-Specific Transgenic Mice Identify Distinct Populations of Transient Amplifying Progenitor Cells And Long-Lived Neural Stem Cells In the Subgranular Zone of the Adult Mouse Brain
… lines were meticulously researched in the subgranular zone (SGZ) of the dentate gyrus. The CstC-CreERT2/Rosa26YFP cells represent a transient amplifying compartment in the SGZ while PLA2G7-CreERT2/Rosa26YFP positive cells comprise a long-lived neural stem cell compartment. Discovery of …
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Epigenetic Regulation of Neurogenesis in Non-Demented Humans with Alzheimer’s Disease Neuropathology
… the capacity for neurogenesis in the subgranular zone of the hippocampus in 4 distinct populations of human subject’s tissue representing the full disease, intermediate cognitive decline, healthy controls, and a poorly characterized group who have all of the histopathological hallmarks …
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Death, survival, and morphological development of hippocampal granule cells born in an inflammatory environment
… subcompartments of the brain; the subventricular zone lining the lateral ventricles, and the subgranular zone (SGZ) in the hippocampal formation. A variety of stimuli such as voluntary exercise, epileptic seizure activity and inflammation can affect the basal level of neurogenesis. In the course …
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The Role of Adult Hippocampal Neurogenesis in Morphine Addiction
… is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG neurogenesis remains unexplored. This …
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The Role of Adult Hippocampal Neurogenesis in Morphine Addiction
… is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG neurogenesis remains unexplored. This …
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The Role of Notch1 in Adult Hippocampal Neurogenesis and Function
… occurs throughout life in the hippocampal subgranular zone (SGZ) and is potently stimulated by exercise, but the underlying mechanisms are still poorly defined. Notch1 is a master regulator of developmental neurogenesis, yet its role in adult hippocampal neurogenesis is unclear. To test the …
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The Role of Glutamate Transporters in Early Postnatal Hippocampal Neurogenesis
… neurogenesis has been well-characterized in the subgranular zone (SGZ) of the hippocampal dentate gyrus however, early postnatal development of the dentate gyrus and changes in the neurogenic niche during this time have not been well-studied. Using a well-characterized transgenic mouse that …
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Modulation of the Hippocampal Neurogenic Program by the Circadian Clock Machinery and the small GTPase, Rasd1/ Dexras1
The mammalian hippocampal subgranular zone (SGZ) is home to a limited pool of quiescent neural stem/ progenitor cells (QNPs). These cells respond to intrinsic and extrinsic physiological changes, embark on the neurogenesis program and give rise to glutamatergic granule neurons that populate the …
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Regulation of Adult Neurogenesis by the ERK5 MAPK Signaling Pathway and its Functional Implications in Learning and Memory as well as Olfaction
… regions in the adult mammalian brain, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) along the lateral ventricles. External stimuli including environmental enrichment activities and olfactory stimulation induce adult neurogenesis. Thus, adult neurogenesis …
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The Role of Adult Neurogenesis in Cocaine Addiction
… the adult hippocampus in a region known as the subgranular zone (SGZ). This process is dynamically regulated and new neurons are thought to be important for certain types of spatial learning and memory. Proliferation of SGZ neural progenitors is decreased by drugs of abuse, yet it is not clear …
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Regulation of Adult Hippocampal Neurogenesis: Insights from Mouse Models of Dementia and Depression
… neurogenesis is largely complete by birth, the subgranular zone (SGZ) in the adult hippocampus continues to produce functional young neurons. The last decade has produced a multitude of research demonstrating that the process of SGZ neurogenesis is dynamically regulated. Stimuli that negatively …
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The Impact of Chronic Morphine on Adult Hippocampal Progenitor Cells and the Neurogenic Niche
… of new neurons persists in the adult hippocampal subgranular zone (SGZ). Adult neurogenesis is dynamically regulated and thought to be important for certain types of spatial learning and memory. SGZ proliferation and neurogenesis are decreased by chronic morphine, yet how this alteration occurs is …
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The crucial role of reelin in a preclinical model of depression
… reelin expression in the dentate gyrus (DG) subgranular zone (SGZ) and depression-like behaviour, namely immobility in the forced swim test (FST). In the second experiment, the potential antidepressant effect of reelin (at either 3μg or 5μg either every 5 or 10 days) via lateral tail vein …
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Effects of Proton Radiation and Pomegranates on Hippocampus and Behavior
… has been shown to suppress neurogenesis in the subgranular zone of the hippocampus, a key area for learning and memory. Furthermore, some evidence suggests that compounds found in fruits and vegetables (e.g. polyphenols) may offer some protection against the cellular effects of radiation. Few …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
… neurogenesis takes place in the subventricular zone of the lateral ventricle and in the subgranular zone (SGZ) of the hippocampus dentate gyrus. Numerous evidences in the literature demonstrate that neurogenesis decreases during aging and it is impaired in neurodegenerative diseases and after …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
… neurogenesis takes place in the subventricular zone of the lateral ventricle and in the subgranular zone (SGZ) of the hippocampus dentate gyrus. Numerous evidences in the literature demonstrate that neurogenesis decreases during aging and it is impaired in neurodegenerative diseases and after …
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Generating a proteomic profile of neurogenesis, through the use of human foetal neural stem cells
… However, adult neurogenesis does continue in the subgranular zone of the hippocampus from quiescent adult neural stem cells. Traditionally neural stem cells were cultured as neurospheres, a heterogeneous agglomeration of neural cells at various stages of differentiation. This heterogeneity …
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Cadmium exposure impairs adult neurogenesis, cognition, and olfactory memory in mice
… to two specific regions in the adult brain: the subgranular zone (SGZ) in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) along the lateral ventricles. These adult-born neurons in the SGZ and SVZ contribute to hippocampus-dependent memory and olfaction, respectively. The …
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Effect of Epigallocatechin-3-gallate on a pattern separation task and hippocampal neurogenesis in a mouse model of Down syndrome
… and cells were manually counted throughout the subgranular zone of the dentate gyrus. The euploid controls had significantly more BrdU labeled cells than Ts65Dn mice, however, EGCG does not appear to increase proliferation of the hippocampal neuroprogenitor cells. This is the first report of …
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The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis
… the ability to generate new neurons: the subgranular zone of the hippocampus (SGZ) and the subventricular zone (SVZ) lining the lateral ventricles in the forebrain. Several studies have suggested that SVZ neural progenitor cells in the adult brain can migrate into regions other than the …
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