Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"subgenomic RNA"”.
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Construction and evaluation of infectious cDNA clones and analysis of packaging determinants of Soybean dwarf virus
… either of these cDNA clones encapsidated genomic RNA (gRNA), but small subgenomic RNA (SsgRNA) was encapsidated by only one isolate and hence its packaging was isolate specific. Site-specific, deletion and domain-exchange mutagenesis indicated that, open reading frames (ORFs) 1, 2, 4, and 5 and …
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Transcriptional and Translational Products of Avian Erythroblastosis and Avian Myeloblastosis Viruses
… cells were found to contain two viral related RNA species of 28 S and 21 S. Both RNA species contain the AEV unique sequences and the "strong stop" region of the viral genome, as detected by cDNA hybridizatin. In addition to the 28 S RNA, which is the genomic RNA of AEV, the 21 S subgenomic RNA …
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Viral and Host Genetic Determinants of Hepatitis C Virus Persistence and Interferon Resistance
… (IFN)-based therapy. The development of the HCV RNA replicon system has allowed the study of persistent HCV RNA replication in tissue culture. We evaluated HCV/IFN interactions within a long-term culture system of Huh7 cell lines harboring different variants of an HCV genotype 1b subgenomic RNA …
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Algorithm development for RNA structure prediction in RNA viruses
RNA structures play many different roles in the life cycles of RNA viruses, including in directing translational control, genome replication, subgenomic RNA synthesis, and encapsidation. However, predicting these structures can be challenging, especially when it comes to pseudoknots, long-range …
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Strucutre-function studies of the venezuelan equine encephalitis virus 5'UTR promoter element and its role in attenuation of the virus
RNA structural elements play critical roles in several viral processes. An \r\nattempt to elucidate the role of one such RNA structural element encoded by the 5’ \r\nUntranslated Region (5’UTR), in regulating virus replication and attenuation of \r\nVenezuelan equine encephalitis virus (VEEV) is …
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Characterisation of the Mechanism of Norovirus VPg-Nucleotidylylation
… compared to other viruses. Infectious norovirus RNA is covalently linked to VPg (viral protein genome-linked) at the 5’ end of the genome through VPg-mediated RNA priming of viral RNA synthesis. While poorly understood mechanistically, this process is reliant on the addition of a nucleotide to a …