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Showing 1 to 20 of 440 for “"subcutaneous"”.
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Subcutaneous and oral delivery of insulin
… to prepare, optimize, characterize and compare a subcutaneous/oral delivery system for insulin. The effect of various low molecular weight chitosans (LMWCs) on the stability of insulin, using USP HPLC methods, was investigated. Insulin was found to be stable in a polyelectrolyte complex (PEC) …
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Continuous Subcutaneous Insulin Infusion in Comparison to Subcutaneous Insulin Injections in the Preschooler with Type 1 Diabetes Mellitus
… is fatal unless treated with insulin of which subcutaneous injection is the most common and oldest method of administration. Continuous subcutaneous insulin infusion (CSII) via insulin pump therapy has provided patients and families with a delivery method that addressed challenges of metabolic …
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The Effect of Exercise on Regional Subcutaneous Fat Accumulations
Made available in DSpace on 2014-12-04T21:57:17Z (GMT). No. of bitstreams: 1 6001681.pdf: 7397944 bytes, checksum: b46f5b9ef34aaad68d400aa977614500 (MD5) Previous issue date: 1960
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Testing the metabolic sink postulate: subcutaneous adipose tissue the protective depot
… [1, 2]. Conversely, peripheral adiposity, subcutaneous/gluteofemoral adipose tissue accumulation, is considered protective against metabolic disease [3, 4]. It is proposed that the subcutaneous adipose depot functions as a "metabolic sink" to sequester and store lipid from circulation, …
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Characterizing Muscle and Subcutaneous Adipose Tissue Imaging Phantoms for NMR Application
… volume in vivo. The phantoms simulate muscle and subcutaneous adipose tissues (SCAT) and assure the repeatability and accuracy of the technique. We determined that the 40% phantoms model muscle tissue and 70% model SCAT. The microstructure of the 40% phantoms was changed by controlling temperature …
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Diethylstilbestrol Nanosuspensions for Prostate Cancer: Subcutaneous Sustained Release Formulations and Pre-clinical PK/PD Evaluations
… toxicities. Thus, our aim was to develop a subcutaneous sustained release nanosuspension formulation of DES, which would circumvent the first pass effect of DES, potentially reducing the thromboembolic and cardiovascular complications and maintaining or improving the efficacy of DES by …
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Pharmacokinetics of a novel cytosine arabinoside subcutaneous protocol in dogs with meningoencephalomyelitis of unknown etiology
… properties of CA when administered as repeated subcutaneous injections over an 8h period to dogs with MUE in order to determine if this amenable administration protocol is a viable alternative to more laborious CRI administration. The primary objective was to describe PK parameters of CA when …
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Development and biophysical characterization of a hyaluronic acid – vitamin E conjugate as a subcutaneous delivery platform
… applicability of protein therapeutics delivered subcutaneously. Hyaluronic acid, a ubiquitous polysaccharide of the extracellular matrix often used in drug delivery applications, was hydrophobically functionalized by the addition of glycine-modified vitamin E (-tocopherol) to form a …
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Comparison of quality of life in diabetics using insulin injection therapy versus subcutaneous insulin infusion therapy
<p>The goal of this study was to determine the effectiveness of insulin delivered via multiple injections or by infusion via a pump on the quality of life in adult insulin-dependent diabetics. Four parameters, namely hemoglobin A1C (3 month average blood sugar levels), self-reported healthy eating …
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Fatty Acid Composition of Diets, Metabolism, and Deposition in Subcutaneous Adipose Tissue of Pasture and Feedlot Finished Cattle
An experiment was conducted to evaluate the effects of pasture finishing versus high-concentrate finishing, over time, on fatty acid metabolism in Angus crossbred (n = 24) beef steers. Ruminal fluid, serum, and adipose tissue biposies were obtained on d 0, 28, 84, and 140. Pasture forages and diet …
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The Eating Behaviours, Quality of Life and Cardiometabolic Risks of Adults with Type 1 Diabetes using Continuous Subcutaneous Insulin Infusion Therapy
Evidence suggests continuous subcutaneous insulin infusion (CSII) is an effective method of achieving glycaemic control in those with Type 1 diabetes (T1D). Among the advantages of CSII is the opportunity for patients to potentially discard the dietary inflexibility imposed by other regimes such as …
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A three constituent mixture theory model of cutaneous and subcutaneous tissue in the context of neonatal pressure ulcer etiology and prevention
<p>Localized ischemia, impaired interstitial fluid flow, and sustained mechanical loading of cells have all been hypothesized as mechanisms of pressure ulcer (PrU) etiology. Time-varying loading has experimentally been shown to increase fluid flow in human skin <em>in vivo.</em> Towards the design …
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