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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"subchondral bone"”.
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The effect of distance between hole and hole to the structural stability of subchondral bone in the microfracture surgery
… of greater cell drainage after exposure of subchondral bone layer shoud affect the biomechanical property the overall subchondral bone. We hypothesis distance between hole and hole is will be correlated with the structural stability subchondral bone, in the microfracture surgery. In this …
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Evaluation of Two Techniques of Cancellous Bone Grafting of Experimental Subchondral Bone Cysts in the Medial Femoral Condyles of Horses
… condyles of 5 horses to mimic clinical cases of subchondral bone cysts after debridement. The defects were created with either a standard square ended drill bit or a compaction drill bit. The compaction drill bit compresses bone laterally and distally creating a dense wall and floor. Twelve-mm …
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Comparison of healing of full-thickness cartilage vs. full- thickness cartilage and subchondral bone defects in the equine third carpal bone
… tissue produced by defects which exposed the subchondral bone· plate and those which penetrated the subchondral bone plate to expose the subchondral marrow spaces was compared in the equine third carpal bone. Specimens were examined four and six months after surgery. Exposure of the …
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Osteochondral properties and relationships in the synovial joint
… of articular cartilage and its underlying subchondral bone using an equine model. Thus, the objectives of this study were: (1) to determine the structural and mechanical properties of equine cartilage, (2) to determine the bone mineral density of the underlying subchondral bone, (3) to …
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Funktionell-anatomische Untersuchungen an den Zehengelenken (Articulationes interphalangeae) der Schultergliedmaße des Pferdes
… (CT-OAM), the distribution of the subchondral bone density was determined topographically in three-dimensional reconstructions of the distal and proximal interphalangeal joints. The specimens were divided into 6 age groups. Following exarticulation the joints were evaluated for …
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Biomechanische Untersuchungen am Fesselgelenk (Articulatio metacarpophalangea) des Pferdes
… (CT-CCM) the distribution of the subchondral bone density and the cartilage thickness were determined topographically in the 3D reconstruction of the joint. Generally the subchondral bone density increases in all bones forming the fetlock joint with increasing age of the horses. Up …
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Early Osteoarthritis: A multi-scale structural and mechanical investigation
… in the cartilage, calcified cartilage, and subchondral bone during the early stages of the development of the disease osteoarthritis (OA). The bovine patella was first validated as a model for intact human cartilage. The bovine patella exhibited proliferative and progressive degenerative …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
… interplay between cartilage and the underlying subchondral bone, linking the pathogenesis/regeneration of both tissues. Thus, this thesis seeks to develop hydrogel composites as growth factor and cell delivery vehicles to study the regeneration of osteochondral tissue. First, we investigated the …
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Characterisation and modelling of spinal facet joints
… surface and the trabecular architecture of the subchondral bone. The specimen-specific model demonstrated that the cartilage curvature, the elastic modulus of the subchondral bone and trabecular architecture of the subchondral bone, influenced the characterisation of the biphasic properties of …
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Smart Materials for Cartilage and Bone Tissue Engineering
… tough surface, and might progressively extend to subchondral bone, leading to the abnormal joint function and disability. Due to the avascular and condensed structure of cartilage, and the limited number of progenitor cells, it is challenging for regeneration of cartilage defects. Furthermore, …
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Advanced Magnetic Resonance Imaging of Osteoarthritis
… localisation of change. Moving to QIBs of subchondral bone, I evaluate the association between measures of subchondral bone architecture derived from MR texture analysis and OA progression in the Osteoarthritis Initiative. The remainder of the thesis describes a prospective observational …
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Morphologische und biomechanische Eigenschaften des Hüftgelenks (Articulatio coxae) des Hundes (Canis familiaris)
… By means of CT-osteoabsorptiometry (CT-OAM) the subchondral bone density was determined qualitatively and quantitatively. The exact topographic distribution of the subchondral bone density was shown in three-dimensional reconstructions of the hip joints in false colour code. The distribution …
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A Clearer Picture of Musculoskeletal Disorders of the Knee and Thumb Through the Lens of Image-Based Finite Element Analysis
… of intra-cyst fluid pressure to the growth of subchondral bone cysts (SBCs). The equine stifle joint provides a natural animal model for studying SBCs. Finite element models were used to examine three cyst sizes of approximately 0.03 cm3 (C1), 0.5 cm3 (C2), and 1 cm3 (C3) in the equine stifle …
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Assessment of Injection Behavior of Commercially-available Bone BSMS for Subchondroplasty Procedures
<p>Subchondroplasty is a procedure that utilized bone substitutes materials (BSMs) or bone cement to correct bone defects in the subchondral bone. The two main materials used to compose BSMs are poly-methyl-methacrylate (PMMA) and calcium phosphate cement (CaP). Currently, there is no optimal bone …
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Mouse models of osteoarthritis and joint injury
… lesions to the articular cartilage and subchondral bone in the joints. The complexity of the disease makes the use of human models impractical and complicated. Therefore, various animal models have been developed to study the progression of OA and possible therapeutic techniques. Of …
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Histological characterization of CT-identified osteoarthritic subchondral cysts and co-registration of CT with MRI
… muscles, joint capsule, synovium, ligaments, and subchondral and metaphyseal bone. The cause of pain in OA is not well understood, but it is known that bone marrow lesions (BMLs) identified in subchondral bone by MRI are an important determinant of pain (Felson et al. 2001; Kumar et al. 2013). …
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A novel osteochondral composite consisting of a self-assembling peptide hydrogel and 3D printed polycaprolactone scaffold : potential for articular cartilage repair
… repair response rely on access to the subchondral bone region. These procedures result in fibrocartilage generation, as opposed to hyaline cartilage, that is variable in structure, composition, and durability. Furthermore, the success rates of these surgeries are also variable. …
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Hedgehog Signaling Modulates Cholesterol Homeostasis in Chondrocytes and in Osteoarthritis
… and calcification of articular cartilage, and subchondral bone changes. Hedgehog (Hh) signaling is known to be activated in human and murine OA. Since Hh signaling regulates Gli-mediated gene expression, we identified Hh target genes that are expressed in chondrocytes. Microarray analyses were …
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The independent and combined effects of rapamycin and metformin on naturally occurring osteoarthritis
… characterized by articular cartilage loss, subchondral bone sclerosis, meniscal calcification, synovitis, and skeletal muscle dysfunction. Inhibiting the mechanistic target of rapamycin (mTOR) and stimulating AMP-activated protein kinase (AMPK) has extended lifespan and protected against …
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Estimulación de la síntesis de colágeno en cultivos celulares. Posible tratamiento de enfermedades degenerativas mediante la dieta
… joint until it disappears to expose the subchondral bone. Cartilage joint has an abundant extracellular matrix, which reaches 95% of the volume of tissue and is formed primarily by collagen, which constitutes 60% of the dry weight, and proteoglycans. The main hypothesis of this Thesis is …
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