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Showing 1 to 20 of 41 for “"subchondral"”.
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Histological characterization of CT-identified osteoarthritic subchondral cysts and co-registration of CT with MRI
… muscles, joint capsule, synovium, ligaments, and subchondral and metaphyseal bone. The cause of pain in OA is not well understood, but it is known that bone marrow lesions (BMLs) identified in subchondral bone by MRI are an important determinant of pain (Felson et al. 2001; Kumar et al. 2013). …
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Changes in 3 Dimensional Microstructures of Subchondral Cancellous Bone of Distal Femur in Early Osteoarthritis
… not only by articular cartilage but also by subchondral cancellous bone, ligaments, and synovium. This study was designed to explore what changes occurs in subchondral cancellous bone in early osteoarthritis and find out the relation between cartilage damage and microstructural changes of …
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The effect of distance between hole and hole to the structural stability of subchondral bone in the microfracture surgery
… of greater cell drainage after exposure of subchondral bone layer shoud affect the biomechanical property the overall subchondral bone. We hypothesis distance between hole and hole is will be correlated with the structural stability subchondral bone, in the microfracture surgery. In this …
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Comparison of healing of full-thickness cartilage vs. full- thickness cartilage and subchondral bone defects in the equine third carpal bone
… tissue produced by defects which exposed the subchondral bone· plate and those which penetrated the subchondral bone plate to expose the subchondral marrow spaces was compared in the equine third carpal bone. Specimens were examined four and six months after surgery. Exposure of the …
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Evaluation of Two Techniques of Cancellous Bone Grafting of Experimental Subchondral Bone Cysts in the Medial Femoral Condyles of Horses
… condyles of 5 horses to mimic clinical cases of subchondral bone cysts after debridement. The defects were created with either a standard square ended drill bit or a compaction drill bit. The compaction drill bit compresses bone laterally and distally creating a dense wall and floor. Twelve-mm …
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Funktionell-anatomische Untersuchungen an den Zehengelenken (Articulationes interphalangeae) der Schultergliedmaße des Pferdes
… (CT-OAM), the distribution of the subchondral bone density was determined topographically in three-dimensional reconstructions of the distal and proximal interphalangeal joints. The specimens were divided into 6 age groups. Following exarticulation the joints were evaluated for …
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Osteochondral properties and relationships in the synovial joint
… of articular cartilage and its underlying subchondral bone using an equine model. Thus, the objectives of this study were: (1) to determine the structural and mechanical properties of equine cartilage, (2) to determine the bone mineral density of the underlying subchondral bone, (3) to …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
… interplay between cartilage and the underlying subchondral bone, linking the pathogenesis/regeneration of both tissues. Thus, this thesis seeks to develop hydrogel composites as growth factor and cell delivery vehicles to study the regeneration of osteochondral tissue. First, we investigated the …
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Biomechanische Untersuchungen am Fesselgelenk (Articulatio metacarpophalangea) des Pferdes
… (CT-CCM) the distribution of the subchondral bone density and the cartilage thickness were determined topographically in the 3D reconstruction of the joint. Generally the subchondral bone density increases in all bones forming the fetlock joint with increasing age of the horses. Up …
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Early Osteoarthritis: A multi-scale structural and mechanical investigation
… in the cartilage, calcified cartilage, and subchondral bone during the early stages of the development of the disease osteoarthritis (OA). The bovine patella was first validated as a model for intact human cartilage. The bovine patella exhibited proliferative and progressive degenerative …
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The Effect of CT Display Window and Image Plane on Diagnostic Certainty for Characteristics of Canine Elbow Dysplasia
… the presence or absence of hypoattenuating MCP subchondral defects, in situ MCP fissures, discrete MCP fragments, irregularity of the radial incisure of the ulna, subchondral sclerosis of the trochlea humeri, osteochondrosis or kissing lesions, and joint incongruity. Level of diagnostic …
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Characterisation and modelling of spinal facet joints
… surface and the trabecular architecture of the subchondral bone. The specimen-specific model demonstrated that the cartilage curvature, the elastic modulus of the subchondral bone and trabecular architecture of the subchondral bone, influenced the characterisation of the biphasic properties of …
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Smart Materials for Cartilage and Bone Tissue Engineering
… tough surface, and might progressively extend to subchondral bone, leading to the abnormal joint function and disability. Due to the avascular and condensed structure of cartilage, and the limited number of progenitor cells, it is challenging for regeneration of cartilage defects. Furthermore, …
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Advanced Magnetic Resonance Imaging of Osteoarthritis
… localisation of change. Moving to QIBs of subchondral bone, I evaluate the association between measures of subchondral bone architecture derived from MR texture analysis and OA progression in the Osteoarthritis Initiative. The remainder of the thesis describes a prospective observational …
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The independent and combined effects of rapamycin and metformin on naturally occurring osteoarthritis
… characterized by articular cartilage loss, subchondral bone sclerosis, meniscal calcification, synovitis, and skeletal muscle dysfunction. Inhibiting the mechanistic target of rapamycin (mTOR) and stimulating AMP-activated protein kinase (AMPK) has extended lifespan and protected against …
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Morphologische und biomechanische Eigenschaften des Hüftgelenks (Articulatio coxae) des Hundes (Canis familiaris)
… By means of CT-osteoabsorptiometry (CT-OAM) the subchondral bone density was determined qualitatively and quantitatively. The exact topographic distribution of the subchondral bone density was shown in three-dimensional reconstructions of the hip joints in false colour code. The distribution …
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A Clearer Picture of Musculoskeletal Disorders of the Knee and Thumb Through the Lens of Image-Based Finite Element Analysis
… of intra-cyst fluid pressure to the growth of subchondral bone cysts (SBCs). The equine stifle joint provides a natural animal model for studying SBCs. Finite element models were used to examine three cyst sizes of approximately 0.03 cm3 (C1), 0.5 cm3 (C2), and 1 cm3 (C3) in the equine stifle …
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Comparing Wear of the Osteoarthritic Temporomandibular Joint and Distal Interphalangeal Joint: A Cadaveric Study
… involving degeneration of articular cartilage, subchondral bone, and adjacent tissues, often affecting multiple joints in an individual. This study aimed to determine whether OA severity and spatial wear patterns are concordant across joints with distinct biomechanics and ossification processes …
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Assessment of Injection Behavior of Commercially-available Bone BSMS for Subchondroplasty Procedures
… or bone cement to correct bone defects in the subchondral bone. The two main materials used to compose BSMs are poly-methyl-methacrylate (PMMA) and calcium phosphate cement (CaP). Currently, there is no optimal bone material substitute in the market that can provide both the adequate mechanical …
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