Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"subcellular targeting"”.
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Methods for Identifying Subcellular Targeting Ligands and Selected Applications
Subcellular localization plays an essential role in targeting drug therapies as generally the pro-drug or linker relies on physical conditions of a particular subcellular compartment to function. We developed two methods that allow for selecting targeting ligands that both internalize specifically …
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Specifying molecular determinants of the subcellular targeting of synaptic and extrasynaptic GABA A receptors
… subtypes segregate so precisely to different subcellular locations is not understood. In this study, I have expressed the recombinant g2 and d GABA-A receptor subunits in cultured hippocampal neurons to analyze the differential cell surface expression and sub-membrane segregation of synaptic …
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Effect of rare and common single amino acid substitutions on DISC1 subcellular targeting and functional interaction with ATF4
… is a molecular scaffold residing in multiple subcellular compartments, where it regulates the function of interacting proteins with key roles in neurodevelopment and plasticity. Both common and rare DISC1 missense variants are associated with risk of mental illness and/or brain abnormalities …
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Expression of microbial rhodopsins in retinal neurons with subcellular targeting motifs: for the study of the structure/function of aii amacrine cells and for vision restoration
<p>Protein-targeting motifs serve as addresses for subcellular protein localization. This feature of targeting-motifs was used to study the retina. The first part of the dissertation reports in the axonless spiking AII amacrine cell of the mammalian retina a dendritic process sharing organizational …
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Determination of the molecular mechanism of cell-to-cell movement in squash leaf curl geminivirus
… MP which are responsible for the functions of subcellular targeting and protein:protein interaction. Finally, I will discuss the potential for post-translational phosphorylation in regulating subcellular targeting and interaction between the MPs.
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Targeted expression of the anti-HIV microbicide lectin griffithsin in maize and tobacco
… systems, vector systems, codon optimisations and subcellular targeting. (Maclean et al., 2007; Yang et al., 2005). The latter sometimes results in unexpected locations which might reflect on an inherent property of the protein itself or specifically be associated with the plant organ involved …
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Axon/dendrite Targeting of Metabotropic Glutamate Receptors by Their Cytoplasmic Carboxy Terminal Domains
The subcellular targeting of neurotransmitter receptors is vital in controlling polarized information flow in the brain. We show here that metabotropic glutamate receptors are differentially targeted when expressed from defective viral vectors in cultured hippocampal neurons: group I mGluR1a and …
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Calcium -dependent protein kinases are myristoylated and associated with different membranes in Arabidopsis thaliana
… fraction. However, little is known about the subcellular locations of individual CDPKs or the mechanisms involved in targeting them to those locations. Arabidopsis contains 34 genes that are predicted to encode CDPKs and 28 of the predicted CDPK proteins have potential myristoylation motifs at …
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Fluorescence resonance energy transfer-based subcellular visualization of FAK/Src activation by chemical and mechanical environment
… high spatiotemporal resolution. Utilizing the subcellular-targeted Src biosensors, I found two distinct Src populations at different microdomains of plasma membrane. In response to chemical stimulations, the activation of Src population at lipid rafts was slower and weaker compared to that …
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Subcellular and functional analyses of two small heat shock proteins and protein kinases from peroxisomes of Arabidopsis thaliana L.
Um neue Erkenntnisse über die Rolle von molekularen Chaperonen und eine mögliche post-translationale Regulation des Peroxisomen-Stoffwechsels zu gewinnen, wurde mit Hilfe einer in silico Analyse das Arabidopsis Proteom nach regulatorischen Proteinen durchsucht, welche eine mögliche …