Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 197 for “"subcellular localization"”.
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Mechanism and Regulation of ERK2 Subcellular Localization
Dynamic changes in the localization of activated proteins can be obligatory events in signaling networks that control cell behavior. ERK1/2 activation contributes to regulated processes such as proliferation, differentiation and survival through the phosphorylation of multiple nuclear and …
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Subcellular Localization of Nicotiana tabacum TGA Transcription Factors
Die Salicylsäure (SA) ist ein wichtiges Signalmolekül bei der Regulation der pflanzlichen Pathogenabwehr. as-1-ähnliche cis-Elemente in den Promotoren von vielen Abwehrgenen vermitteln SA- und auch Auxin-induzierbare Genexpression. Diese Elemente werden vom ASF-1/SARP-Proteinkomplex erkannt, dessen …
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Inquiries into the subcellular localization of the glucocorticoid receptor.
… assay was employed to characterize the subcellular localization of a series of GR mutants effectively truncating, deleting or mutating specific regions of the receptor N-terminus. In the first part of my study, I delimited a specific region of GR (amino acids 100--200 of the N-terminus) …
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Investigation into the Akirin Subcellular Localization and Developmental Interactions
… defects. This investigation focused on both the subcellular localization of Akirin based on a putative nuclear localization signal and the genetic interaction between Akirin and the Nucleosome Remodeling Deacetylase (NuRD) complex. Through transfection of <em>Drosophila</em> S2 cells with Akirin …
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Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
… regulated by sequestration in the nucleus, and relocalization of Net1 outside the nucleus is required to stimulate RhoA activation, actin cytoskeletal reorganization, and oncogenic transformation. However, regulatory mechanisms controlling the extranuclear localization of Net1 have not been …
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Subcellular Localization and Activity of the Multidrug Resistance Protein 1
<p>Multi-drug resistance or MDR is a major impediment to the successful administration of chemotherapy. Broadly defined, the term MDR applies to any mechanism the cell uses to counter the effects of chemotherapeutic agents, protecting the cell at once against the toxicity of many, structurally …
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Subcellular localization and visualization of RecA and ImuAʹ in mycobacteria
… to explore the dynamics of their expression and subcellular localization within live Msm cells. To this end, fluorescently tagged versions of ImuAʹ and RecA were constructed and shown to retain functional activity in UV-induced mutagenesis but not survival of mitomycin C (MMC) treatment. The …
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Molecular Genetics and Subcellular Localization of Flavonoid Metabolism in Arabidopsis
… that can be tested regarding pathway regulation, localization, and function. The goal of the work presented here was to test the metabolon model using the flavonoid biosynthetic pathway in Arabidopsis, which has been hypothesized to exist as a metabolic enzyme complex. Five novel mutants of the …
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Protein Composition and Subcellular Localization of the De Novo Lipogenic Metabolon
Pages 11-34 are incorrectly numbered as pages 9-32, and pages 35-124 are incorrectly numbered as pages 34-123.
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Subcellular Localization of Tobacco Salicylic Acid Binding Protein 2 in Plants.
… resisting microbial infection. The precise localization of SABP2 in plants is not known. SABP2 has not been shown to have any targeting signal peptides. This study was designed to determine localization of SABP2 in tobacco plants. Biochemical and immunological studies using antibodies …
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Analysis of the subcellular localization of proteins implicated in Alzheimer’s disease
… encoding truncated PSEN1 protein. The subcellular location of the PSENs has been controversial, with studies detecting these proteins in multiple areas in the cell. However recent research has shown that the PSENs are enriched in the mitochondria associated membranes (MAM). The …
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14-3-3Sigma Negatively Regulates The Stability and Subcellular Localization of Cop1
… We discovered that 14-3-3σ controlled COP1 subcellular localization and protein stability. Investigation of the underlying mechanism suggested that, upon DNA damage, 14-3-3σ bound to phosphorylated COP1 at S387, resulting in COP1 translocation to the cytoplasm and cytoplasmic COP1 …
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Subcellular Localization of Human T-cell Leukemia Virus Type 1 Tax Oncoprotein
… between the two compartments via defined nuclear localization and nuclear export signals (NLS and NES, respectively), but the mechanisms regulating nucleocytoplasmic shuttling and targeting of Tax to distinct subcellular regions have yet to be determined. In this study we identified regions in Tax …
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STUDIES ON THE SUBCELLULAR LOCALIZATION OF 3-BETA- HYDROXYSTEROID DEHYDROGENASE IN STEROIDOGENIC CELLS
… like the adrenal cortex and gonads. However, its subcellular localization that provides the cellular site of enzyme activity remains confusing and has been a topic of debate. Our study explores the subcellular localization of HSD3B using an approach for precise immunofluorescence, providing …
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Screening for kinases regulating subcellular localization of clock proteins using human kinome library
국문 요약 ⅰ 차례 ⅳ 그림 차례 ⅶ 표 차례 ⅸ Ⅰ. 서론 1 A. 생체시계의 분자 생물학적 기전 1 B. 인산화에 의한 생체시계 조절 2 C. 핵 이동 5 D. 연구의 필요성 5 Ⅱ. 재료 및 방법 6 A. Plasmids and cloning 6 B. Establishment of human kinome expression library 9 C. Cell culture and transfection 9 D. Fluorescence microscopy 11 E. Quantitative real-time RT-PCR 12 F. …
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Characterization of synaptotagmin 7 function in neurotransmission and its subcellular localization at synapses
Synaptic vesicle (SV) fusion is dependent on proteins that can sense Ca²⁺ and trigger fusion with the plasma membrane. Neurotransmitter release occurs during a rapid synchronized phase of SV fusion mediated by the Ca²⁺ sensor Synaptotagmin 1 (SYT1). A slower SYT1-independent asynchronous phase is …
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Mapping of the repression domain and the subcellular localization of the ABF-1 protein
… ability of E2A. To complement these studies, the subcellular localization and nuclear localization signal of GFP-tagged ABF -1 proteins was performed using fluorescent microscopy. These studies suggest that ABF-1 exerts it function through the bHLH domain and the region of the nuclear localization …
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