"structure based drug design (SBDD)" · 2 results · Global ETD Search

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Showing 1 to 2 of 2 for “"structure based drug design (SBDD)"”.

Leveraging Local Perturbations to Map Allosteric Networks of Phosphatases

Mehlman, Tamar (Skaist)The Graduate School and University Center of The City University of New York2023

… small-molecule fragments binding to PTP1B. These structures also indicated that temperature can modulate protein conformational responses to ligand binding, leading to new insights into allosteric networks. Building on fragment-bound structures, I worked to apply structure based drug design (SBDD) …

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DESIGN AND DEVELOPMENT OF RNA-BASED DRUGS USING MOLECULAR DYNAMICS SIMULATIONS AND ARTIFICIAL INTELLIGENCE METHODS

ALBANI, MARCOUniversità degli Studi di Milano2026

RNA-based therapeutics represent a powerful class of drugs offering precise targeting for genetic disorders, cancer, and infectious diseases. Several RNA-based modalities have been developed, including messenger RNAs (mRNAs), small interfering RNAs (siRNAs), microRNAs (miRNAs), antisense …

milano Repository record for DESIGN AND DEVELOPMENT OF RNA-BASED DRUGS USING MOLECULAR DYNAMICS SIMULATIONS AND ARTIFICIAL INTELLIGENCE METHODS (opens in a new tab)