Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 164 for “"structure/function relationships"”.
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Structure-function relationships of metalloenzymes
Anhand der Modellsysteme [NiFe] Hydrogenase und Superoxid Reduktase wurden Struktur-Funktionsbeziehungen von Metalloenzymen, die die Umwandlung kleiner Moleküle katalysieren, mittels theoretischer und spektroskopischer Methoden analysiert. Der erste Teil dieser Arbeit ist der Charakterisierung …
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Decoding structure-function relationships of glycans
… glycan-protein interactions, elucidating glycan structure-function relationships is challenging. Thus, uncovering the biological function of glycans requires an integrated approach, incorporating structural analysis of glycans, and glycan-proteins interactions with functional analysis. In this …
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UNCOVERING STRUCTURE-FUNCTION RELATIONSHIPS IN CHROMATIN ARCHITECTURE
… thus, genome folding architecture plays a functional role in replication. Finally, as part of the 4D-Nucleome consortium analysis, we integrate genome folding with other features of nuclear spatial positioning (SPIN states) and transcription. We show a common unifying trend amongst these …
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Structure-function relationships in monotopic phosphoglycosyl transferases
Complex glycans play essential roles in prokaryotic and eukaryotic biology. While this ubiquitous post-translational modification takes a diversity of forms, many glycoconjugate biosynthesis pathway across domains of life follows a common logic. Glycan assembly is initiated by a phosphoglycosyl …
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Structure-function relationships in human brain development
The integration of anatomical, functional, and developmental approaches in cognitive neuroscience is essential for generating mechanistic explanations of brain function. In this thesis, I first establish a proof-of-principle that neuroanatomical connectivity, as measured with diffusion weighted …
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Structure-Function Relationships in Organic Charge-Transfer Complexes
… in a partial degree of ionicity and a band structure that is a hybrid of the parent compounds, allowing the complex to exhibit interesting physical characteristics. These include metallicity, ambipolar semiconductivity, photoconductivity, ferroelectricity, and more. The focus of this work is …
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Structure-function relationships of copper and molybdenum complexes
The crux of this research: structure-function relationships of transition metal complexes. Firstly, working to further predecessor’s findings using borane-substituted N-heterocyclic carbenes (NHCs) to modulate the emission of copper complexes. The second project focused on understanding the …
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The Structure-Function Relationships in Laminated Barrier Films
… the physical properties of the polymer and its structure. The polymer films of interest fall into 3 categories, polyamides, polyesters and polyolefins, as well as laminated films using these polymers. A wide variety of additives are used both in polymers and foodstuffs. Four additives were used …
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Investigations of conserved structure-function relationships and enzymatic evolution
… Recent studies have provided several crystal structures of SufS including two variants displaying stalled intermediates of the desulfurase reaction. Combining the structural data with biochemical investigations has uncovered several key elements in SufS activity. SufS is a homodimer proposed …
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Structure-Function Relationships of Elements of the Bacteriophage f1 Genome
… coli transcription unit, and by studies of its function in its usual phage context. Expression of the f1 major coat (gene VIII) protein was studied in vivo in cells infected with variant f1 phage whose genomes had been restructured in vitro. This gene with its most proximal promoter and …
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Exploring Sequence-Structure-Function Relationships in Proteins Using Classification Schemes
… in the number of available protein sequences and structures, the necessity of interpreting this data in comprehensive and meaningful ways becomes increasingly apparent. Identifying and categorizing the functional, structural, and evolutionary relationships between proteins is a key step in …
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Structure-function relationships in bone. Application in orthopedics and endocrinology
Contains fulltext : 146800.pdf (Publisher’s version ) (Open Access)
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Structure/function relationships of the copper proteins nitrite reductase and rusticyanin
This thesis is focused on elucidating the structure/function relationships of two copper proteins, nitrite reductase and rusticyanin using a combined approach of site-directed mutagenesis and X-ray crystallography. Dissimilatory nitrite reductase (NiR) catalyses the reduction of nitrite to nitric …
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Probing structure-function relationships at catalytic surfaces with emerging electroanalytical tools
… to the rational design of new materials and structures. Many techniques based on spectroscopy, scanned probe microscopy, and electrochemistry have been developed to detect surface intermediates. These techniques have been used to chemically identify surface intermediates of many reactions and …
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Yeast flocculation: understanding cell surface structure-function relationships in industrial yeast strains
… the outer layer of the cell wall. Change in the structure and or composition of the cell wall leads to changes in the microbial adhesion properties. Exploring more into the cell wall and studying the nanoscale structure of the yeast cell wall would thus be beneficial to augment our understanding …
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Fret-Based Investigations of The Structure-Function Relationships In The Nmda Receptor
… modulation, and its especially important functional roles in synaptic plasticity, excitotoxicity, and more. In recent years, a wealth of structural information has come about describing endpoint structures to high resolution, but such structures are unable to fully resolve the movements …
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Sequence-structure-function relationships of glycosyltransferases in families GT43, GT47, and GT64
… for controlling the diversity of glycan structures. The study of glycosyltransferases can therefore grant insight into the biology of the Golgi apparatus and the ætiology of disease, as well as providing a means to engineer carbohydrate structures for therapeutic or material applications. …
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Analysis of Structure-Function Relationships in *Lambda and HK022 Site -Specific Recombination
… presents a multifaceted analysis of protein structure-function relationships pertaining to the Lambda and HK022 Integrase proteins (Int). First, homology-based modeling was used to create a three-dimensional model of the Lambda Int core-binding (CB) domain. The model suggests that all …
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