Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"structural rearrangement"”.
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Investigating the Role of Conformational Flexibility in tRNA Aminoacylation
… for ligand binding, which promotes catalysis by structural rearrangement. Proteins undergo structural rearrangements to bind ligands, regulate access to a catalytic site, or release products. The energetic contribution of protein flexibility to catalysis is not well understood, despite numerous …
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The 1,3-Diazabiphenylene system. synthesis, chemistry, and incorporation into a linearly extended purine analogue
… diazabiphenylene is found to undergo an unusual structural rearrangement on treatment with acid in methanol, providing a substituted isoquinoline. Progress toward the synthesis of the dimensional probe, lin-bcb-adenine, incorporating the 1,3-diazabiphenylene skeleton, is summarized, and the …
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Characterization of cyclic di-GMP binding by the sole Borrelia burgdorferi and Borrelia hermsii PilZ domain-containing proteins
… demonstrated that these proteins exhibit a structural rearrangement when binding c-di-GMP likely significant to downstream activities. Substitution of a highly conserved residue within PlzA altered the structure and charge of the PilZ domain, leading to abolished binding. PlzA and PlzC …
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Coarse-grained Modeling of Protein Dynamics using Elastic Network Models
… of viral and host membrane, undergoes a large structural rearrangement. A striking difference between the two proteins is their shape. VSV-G contains weakly constrained protein segments, the fusion loops, which can undergo large-scale motions at low energetic cost, whereas APH is not obviously …
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A conjugated polymer plastic gel
… each other neighbors. The mechanically induced structural rearrangement from an isotropic to an anisotropic conjugated polymer gel occurs when transitioning from the molten state to the gel state. This study highlights the versatility of incorporating plasticity in the design of conjugated …
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Computational chemistry of organometallic and inorganic species
… of problems related to redox processes and structural rearrangement in inorganic systems. Density functional theory has been used to gain insight into the origin and nature of such reactions. The work presented concerns two main topics: hydrogenase-like systems containing an Fe2 core and …
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Study of the thermal behaviours of intumescent silicate materials
… evolution of water and flammable species ii) the rearrangement of interstitial ions and water molecules iii) the evaporation of water of condensation from silanol groups iv) the decomposition of samples and i) structural rearrangement. Cone calorimetry studies revealed that samples with low polyol …
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Molecular simulation of biomaterials and biomolecules at the solid-liquid interface
… while polymer flexibility is required to capture structural rearrangement and the resulting free energy contributions. Finally, electrostatic interactions between the adsorbing biopolymer and inorganic surface, as well as interactions of the polymer and surface with the surrounding solvent …
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Structure property behavior of an ethylene-propylene-diene ionic terpolymer containing zinc stearate
… the elastic region. SAXS data indicates that structural rearrangement occurs with aging. DSC studies confirmed the effects of aging in that a difference occurred in thermal behavior between 1st and 2nd meltings. DSC also indicated the presence of an impurity, which is believed to be stearic …
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Analysis of the Expression Profiles of Two Isoforms of the Antifungal Protein Osmotin from Gossypium hirsutum
… cells confirmed that an anomalous DNA structural rearrangement or aberrant recombination event probably occurred in the Agrobacterium cells, interdicting the integration of osmotin transgenes into the Arabidopsis and cotton plants. This research provides crucial baseline information on …
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Suspension, yielding, microstructure and applications of bacterial cellulose dispersion
… this purpose. The fiber gels exhibit a dynamic structural rearrangement response to applied stress that is shown to be advantageous in applications like particle suspension and surface coating. The cellulose system and its unique structural and yielding properties are also studied in several …
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Structural mechanisms of experience-dependent synaptic plasticity in the mouse visual cortex
… periods (3 days) of MD has been shown to drive structural plasticity of thalamic input to binocular visual cortex. The exact molecular and synaptic mechanisms responsible for rapid OD shifts remain unclear. In my thesis work, I address the requirement of proper microglial functioning via the …
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Molecular level characterisation of apolipoprotein A-I aggregation leading to fibrils comprising of both α-helical and β-sheet structures
… within tissues and extracellular organs. 30+ structurally and sequentially unrelated proteins have the ability to form amyloid aggregates, all of which contain characteristic features. ApoA-I, the main component in high-density lipoprotein, aggregates and becomes deposited as amyloid, either …
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NMR as a probe for molecular adsorption on metal surfaces in electrochemical environments and at electrified interfaces
… is $\sim$ 3000 s$\cdot$K, indicating a small structural rearrangement. The above T$\sb1\cdot$T results show that the conduction electron of platinum is contributed to the T$\sb1$ relaxations and the carbon atom is attached to the platinum surface. T$\sb2$ measurements of $\sp{13}$C in …
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Single-shot spectroscopy of solid-state photoinduced dynamics far from equilibrium
… observed in PtI chains that suggest long-lived structural and electronic states under high irradiation. The possibility of collective structural rearrangement with a long lifetime is proposed. In bismuth, high photoexcitation measurements traversed the material's potential energy surface along …
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Aggregation Effects on the Rheological, Sedimentation, and Drying Behavior of Colloidal Silica Suspensions
… were observed due to salt bridging effects. Structural rearrangement occurred in the drying films due to capillary-induced effects. These findings demonstrates the importance of extending classical models (i.e., DLVO theory) for predicting interparticle interactions to account for short-range …
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Crystal engineering of 2-periodic Ni- and Co-based, isoreticular, mixed ligand metal-organic frameworks for sorption studies
… pore size, shape, geometry, inner surface, and structural rearrangement of the materials. This allows for tailoring of the structure/properties, and this one of the most appealing features of MOFs and can be of benefit in many applications, for example, enhancing gas sorption capacities. MOFs …
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The influence of mucins on bacterial communities
… glycans were identified as a critical structural component of mucin coatings that are necessary for bacterial repulsion. In Chapter 3, 1 investigate how mucins impact established Pseudomonas aeruginosa biofilms. The data reveal that mucins cause disassembly and structural rearrangement …
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An investigation into the desensitization of neurotransmitter gated ion channels — functional relevance, impact on ganglionic receptor function, and structural insights
… ligand-gated ion channels is likely to undergo structural rearrangement during open-closed and open-desensitized transitions. We found that this region is unlikely to be important during these kinetic transitions, implying that the hinge point to accommodate the tilting of the pore-lining M2 …
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Structure, function, and dynamics of cell motility proteins
… bends and unwinds near residue Arg74. The major structural change is a reorientation of the two Ca2+-binding domains with respect to each other and a rearrangement of α-helices in the N-terminus domain which make the hydrophobic target peptide binding site more accessible. This structural …
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