Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"structural protein"”.
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THE ROLE OF GENETIC VARIANTS OF NON-STRUCTURAL PROTEIN 1 IN DENGUE PATHOGENESIS
The secreted form of dengue non-structural protein 1 (sNS1) can cause vascular leakage, a hallmark of severe disease. This work explored several genetic variants of NS1 present in the viral population with an emphasis on T164S mutation that has been associated with increased intraepidemic disease …
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Investigation of the interplay of yellow fever virus structural protein epitopes and genetic diversity
… the contribution of the envelope (E) protein in YFV attenuation through its role in genetic diversity, tissue tropism and recognition by WT and vaccine specific antibodies that bind E protein. Using infectious clones (i.c.) of both Asibi and 17D viruses, structural chimeras with …
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AlphaFold2 reveals structural patterns of seasonal haplotype diversification in SARS-CoV-2 structural protein variants
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Functional analysis of hepatitis C virus non-structural protein (NS) 3 protease and viral cofactor NS4A
… One of the validated drug targets is the non-structural (NS) protein 3 (NS3) membrane-bound protease. The major aim of this thesis was characterization of NS3 allosteric activation by its viral cofactor, NS4A. We hypothesized that there would be specific residues that dominate the interaction …
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Molecular bases for modulation of host cellular responses by porcine reproductive and respiratory syndrome virus non-structural protein 11
… by PRRS virus (PRRSV) has been investigated. Non-structural protein 11 (Nsp11) contains a nidovirus-specific domain designated as NendoU, and this domain is known to have a endoribonuclease activity. This RNase activity is important but not essential for viral replication in equine arteritis virus …
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Investigating the role of the West Nile virus and Koutango virus envelope protein in virulence phenotypes using structural protein chimeras
… able to study the contribution of an entire protein in the context of a replicative virus. The generation of chimeric flaviviruses bridges this gap by being able to study the contributions of a single protein or domain in the context of a replicative virus. Previous work by McAuley et al. …
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Identification and characterization of a novel structural protein of porcine reproductive and respiratory syndrome virus, the replicase nonstructural protein 2
… of high economic consequence. The PRRSV non-structural protein 2 (nsp2) is a large multifunctional protein encoded by the most genetically diverse region of the genome - the selective pressure potentiating mutation within this region is unknown. Here we report the identification of a unique …
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Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus
… like all other successful viruses, encode proteins that counteract the innate immune response. A number of reports have indicated the papain-like protease (PLpro) domain of SARS-CoV Non-Structural Protein 3 (NSP3) as a powerful interferon antagonist, by suppressing interferon regulatory …
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Characterization of the molecular and biological determinants of viral dissemination from the mosquito midgut: Yellow feber virus in Aedes aegypti
… the midgut to position 36 in the membrane (M) structural protein gene, domain III of the envelope (E) protein gene, non-structural protein gene 2A (NS2A), and position 95 in non-structural protein gene 4B (NS4B). \r\nThe virus distribution and tissue tropisms Asibi, 17D, and a chimera 17D/Asibi …
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Computational studies of biomolecules to explore potential therapeutics for COVID-19 and SAMD9- associated diseases
… public health. Various therapeutics that target proteins of the virus have been studied, which have shown some degree of success. Advancements in computational methods have offered an excellent opportunity to explore biological macromolecule conformations, functions, and pathogenesis. Therefore, …
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Characterisation and expression of ORF2 in genome segment 10 of African horse sickness virus
… of the genome, allowing expression of multiple proteins from a single mRNA. A second additional open reading frame, ORF2, was identified in African horse sickness virus (AHSV) Seg-10 which encodes the non-structural protein NS3. The ORF2 conservation, size, nature, expression, function and …
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Construction of a modified live HP-PRRS virus vaccine and an attenuated listeria vaccine vector using reverse genetics
… the US. According to previous studies, the non-structural protein (NSP) coding region of HP-PRRSV is closely related to the high mortality rate and the structural protein (SP) coding region contributes to the induction of broadly protective neutralizing antibodies. We created a chimeric PRRSV, …
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Peptidazių iš Geobacillus thermoleovorans DSM 15325 kolagenolizinio aktyvumo analizė: M3 proteolizinių fermentų šeimos M3B pošeimio oligopeptidazės ir U32 proteolizinių fermentų šeimos peptidazės charakterizavimas /
… of collagenolysis as collagen is a major structural protein in organisms. The diversity of collagenolytic peptidases from non-pathogenic bacteria remains only fragmentary characterized, whereas the characterization of the diversity of collagenolytic peptidases from eukaryotes and …
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The collagenolytic activity analysis of Geobacillus thermoleovorans DSM 15325 peptidases: characterization of M3 proteolytic enzymes family M3B subfamily oligopeptidase and U32 proteolytic enzymes family peptidase /
… of collagenolysis as collagen is a major structural protein in organisms. The diversity of collagenolytic peptidases from non-pathogenic bacteria remains only fragmentary characterized, whereas the characterization of the diversity of collagenolytic peptidases from eukaryotes and …
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Quantifying collagen-based biological tissues using Fourier-transform-second-harmonic generation imaging
… tissues in 3D. Collagen is the primary structural protein in the human body. Depending on the spatial arrangement of collagen fibers, collagen-based biological tissues can have a wide range of functions and mechanical properties. In addition, many biological tissues consist of 3D …
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Anti-phage defense as a driver of molecular innovation
… system that recognizes a viral structural protein to activate a novel mRNA ADP-ribosyltransferase, thereby halting infection. Next, I examined the diversity and distribution of anti-phage mechanisms encoded by E. coli lysogenic phages – phages capable of integrating into and …
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Characterization of Heterogeneous Material Properties of Aorta Using Nanoindentation
… infrared imaging spectroscopy for determining structural protein, and total protein content. The distributions of these quantified properties across the wall thickness of the porcine descending thoracic aorta were characterized and their relationship with the mechanical properties was …
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Immunomodulation der Kartoffel-Blattrollvirus (PLRV) Multiplikation via Expression virusspezifischer rekombinanter Antikörper in planta
The proteolytical activity of the non-structural protein P1 of Potato leafroll virus (PLRV) leads to the formation of a subset of P1 derivates including P1-C25 and the VPg. In order to study the relevance of P1 and/or its derivate P1-C25 to the viral life-cycle the VH- and VL-domains of a …
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Mechanism of transmissible gastroenteritis virus nsp1-mediated translation inhibition
The non-structural protein 1 (nsp1) proteins of several coronaviruses share a common property to inhibit host gene expression, but use different mechanisms to exert this function. Unlike the nsp1 protein of SARS coronavirus, a group 2b betacoronavirus, the nsp1 protein of transmissible …
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Material properties of actin filament bundles
Actin is an ubiquitous structural protein fundamental to such biological processes as cell motility and muscle contraction. Our model system is the acrosomal process of the Limulus sperm which extends a 60 ýtm long actin bundle during reproduction. It is an example of a biological spring where the …
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