Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"structural plasticity"”.
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EXPERIENCE-DEPENDENT STRUCTURAL PLASTICITY IN A NATURALLY BEHAVING ANIMAL MODEL
… for an animal's survival. Neurons can undergo structural changes, such as branch addition, branch retraction, or altering the number or shape of spines which change the neural connectivity in the brain. The regulation of a neuron's structure may lead to changes in future behavior via altered …
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Kinetochore Structural Plasticity and its Regulation in <i>Saccharomyces cerevisiae</i>
… yeast, <i>S.cerevisiae</i>, to elucidate a novel structural transition of the kinetochore. During anaphase, the microtubule undergoes rapid depolymerization. Kinetochore tracking of microtubule during this phase is critical for chromosome segregation, but how this tracking is achieved is not well …
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Spatiotemporal Dynamics of CaMKI During Structural Plasticity of Single Dendritic Spines
… kinases (CaMKs) are key regulators of spine structural plasticity and long-term potentiation (LTP) in neurons. CaMKs have promiscuous and overlapping substrate recognition motifs, and are distinguished in their regulatory role based on differences in the spatiotemporal dynamics of activity. …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… relationship between [Na+]i and NMDAR-dependent structural plasticity in developing cerebrocortical neurons. Exposure to PbTx-2 was found to sensitize immature neurons to NMDA-induced Ca2+ influx through a Src family kinase (SFK)-dependent pathway. The effects of PbTx-2 on upregulating NMDAR …
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Mechanisms underlying rapid activity-dependent structural plasticity at Drosophila neuromuscular junctions
… to regulate bouton budding. Limk interfaces with structural plasticity by controlling the activity of the actin depolymerizing protein Cofilin. Expression of constitutively active or inactive Cofilin in motor neurons demonstrates that increased Cofilin activity promotes rapid bouton formation in …
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The Effects of Aging on EGFR/pSTAT3-Dependent Gliovascular Structural Plasticity
… result in barrier deficits, but rather induces a plasticity response whereby surrounding astrocytes extend processes to reinnervate vascular vacancies no longer occupied by previously ablated astrocytes. 2) Replacement astrocytes are capable of inducing vasocontractile responses in blood vessels, …
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Towards adaptive neural networks: Bio-inspired principles for functional and structural plasticity
… shape it over a lifetime. One such process is plasticity: the ability of neurons to adapt their synapses. The varying levels of myelination and synaptic development change the behavior of neurons and the brain. In this dissertation, we attempt to imitate this process by employing Hebbian …
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The role of the cold shock protein, RBM3, in cooling, synaptic structural plasticity and neuroprotection
… pruning and regeneration of synapses, known as structural plasticity, is a continuous process in the brain and represents an important point for therapeutic intervention. Recent evidence has shown that synapse loss in mice models of neurodegeneration is due to a failure of synapse regeneration, …
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Long-term activity-induced changes in the brain : a study of translational regulation and structural plasticity
… that cause protein synthesis-dependent forms of plasticity also upregulate protein synthesis via the same mechanisms.
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The adaptive benefits of adult structural plasticity in the mushroom bodies of freely behaving forager honey bees
… of microglomerular volume suggest that the structural differences between the Category 1 and Category 3 brains are very subtle. Microglomerular volume and density changes have been reported to vary with overall MB calycal volume, however the subtle differences we found have never been …
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PLP-Dependent α-Oxoamine Synthases: Phylogenetic Analysis, Structural Plasticity, and Structure-Function Studies on 5-Aminolevulinate Synthase
… that may regulate substrate specificity. The structural plasticity of ALAS has been documented in studies of functional circularly permuted ALAS variants and the single polypeptide chain ALAS dimer (ALAS/ALAS) exhibiting a greater turnover number than wild-type ALAS. An examination of the …
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Role of Intracellular Calcium Stores and Calcium-Permeable AMPARs in Functional and Structural Plasticity in Mouse Hippocampal Slices
… of the association between functional and structural plasticity under physiological conditions, I developed a method to monitor both simultaneously using field potential recordings and two-photon imaging, respectively. I found that functional plasticity induced by sTBS is associated with …
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A Three-Molecule Model of Structural Plasticity: the Role of the Rho family GTPases in Local Biochemical Computation in Dendrites
… modification of preexisting ones. This so-called structural plasticity of neural circuits – their ability to physically change in response to experience – has remained fixed as a primary point of focus in the field of neuroscience. </p><p>A large portion of this effort has been directed towards …
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Experience-dependent dendrite remodeling of GABAergic interneurons in the adult visual cortex
… amount of evidence is demonstrating that structural plasticity is a diverse and ongoing feature that contributes to plasticity in the adult brain. It was previously shown that dendritic arbors of inhibitory interneurons in superficial layer 2/3 can remodel in the adult cortex. Here, we …
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Use-Dependent Plasticity Regulates Sleep Need in Drosophila Melanogaster
… consolidation are reliant upon the expression of plasticity-related genes in Pigment Dispersing Factor: PDF)-expressing ventral lateral neurons: LNvs), a core component of the Drosophila circadian clock. Following social enrichment, LNv projections into the medulla exhibit structural plasticity as …
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Structural mechanisms of experience-dependent synaptic plasticity in the mouse visual cortex
… of an animal shapes behavior through synaptic plasticity. Modification in the strength of synaptic drive can result from adjustments in the strength of existing synapses, creation of new synapses, or removal of existing ones and involves presynaptic, postsynaptic, and extra-synaptic mechanisms. …
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The Diversity of FHF-mediated Ion Channel Regulation
… other hand is involved in a new form of neuronal plasticity called axon initial segment structural plasticity. Knockdown of FGF13 impairs AIS structural plasticity and reduces L-type CaV current through channels known to be important to this new form of plasticity. Both of these novel non-VGSC …
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A system-theoretic approach to global and local regulation in neuron morphologies
Synaptic plasticity is a crucial neuronal mechanism for learning and memory. It allows synapses to change their strength over time. This dissertation focuses on a particular form of synaptic plasticity called synaptic scaling, a homeostatic mechanism that preserves relative synaptic strengths in an …
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Cellular and molecular analysis of neuronal structure plasticity in the mammalian cortex
Despite decades of evidence for functional plasticity in the adult brain, the role of structural plasticity in its manifestation remains unclear. cpg15 is an activity-regulated gene encoding a membrane-bound ligand that coordinately regulates growth of apposing dendritic and axonal arbors and the …
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Messenger RNA Destabilization by -1 Programmed Ribosomal Frameshifting
… directly interact with the CCR5 -1 PRF signal. Structural analyses reveal a complex and dynamic mRNA structure in the -1 PRF signal, suggesting structural plasticity as the underlying biophysical basis for regulation of -1 PRF.
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