Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"structural alteration"”.
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Structural Analysis Of Bulky Thiolate-Protected Gold Nanomolecules
… by the student in this thesis outlines the alteration of these icosahedron-based core geometries. Specifically, by varying the steric hindrance of the –R group for which the sulfur head group is bound, a heightened gold:thiol ratio is achieved. With the application of bulky ligands, most …
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CHARACTERIZATION OF HEPATITIS B VIRUS (HBV) IN HEPATOCELLULAR CARCINOMA (HCC) PATIENTS
… genome involved in integration as well as viral structural alteration is at the 3¿-end of HBx where viral replication/transcription initiates. Upon integration, the 3¿-end of the HBx is often deleted. HBx-human chimeric transcripts, the most common type of chimeric transcripts, can be expressed …
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The Role of Inhibitory Interneurons in a Model od Developmental Epilepsy
… the development of the neocortex produces a structural alteration. Such patients may have other neurological problems, but seizures are the most common symptom. The neuronal mechanisms that link malformation and cortical hyperexcitability are not well understood. Here we have sought to …
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Towards the development of calcium ion batteries
… higher temperature cycling, and chemo-structural alteration of Mo3Se4 increased capacity utilization fourfold. Calcium content of electroactive samples was confirmed by energy dispersive x-ray spectroscopy. X-ray photoelectron spectroscopy and x-ray diffractometry studies provided …
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Evidence Of Distinctive Structural Alterations That Differentiate Adhd Boys With And Without A Comorbid Reading Disability
… However, the extents to which comorbid RD impact structural alteration in children with ADHD have never been investigated. The overall goal of this study was to assess structural alterations in the subcortical, cortical and white matter that may differentiate ADHD/-RD from ADHD/+RD. The general …
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Predictive Modeling of Diffusional Processes Within the Hydrated Layer of Vitrified Nuclear Waste Forms
… a nuclear waste glass and an aqueous solution, a structurally altered, highly hydrated layer forms. The distribution of the glass constituents within this layer has been investigated through development of mathematical models representing the fundamental mechanisms that describe the formation of …
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Migration of tumor cells and leukocytes in extracellular matrix : proteolytic and nonproteolytic strategies for overcoming tissue barriers
… matrix within connective tissues represents a structural scaffold as well as a barrier for motile cells, such as invading tumor cells or passenger leukocytes. It remains unclear how different cell types utilize matrix-degrading enzymes for proteolytic migration strategies and, on the other …
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Molecular mechanism of glycogen phosphorylase gene regulation during Dictyostelium development
… of these elements. However, there were no alterations of gp2 gene expression observed after these deletions. Also investigated was genomic structural alteration in gp1- mutants that were obtained through homologous recombination and antisense RNA. Southern analysis revealed that the normal …
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Mechanistic Study of the Adsorption and Desorption of Proteins on Silica
… can act as a catalyst to facilitate dramatic structural alteration and destabilization of the protein. Understanding the mechanisms governing protein adsorption to a solid/liquid interface is pertinent in the wide range of applications in which this ubiquitous phenomenon plays a key role. One …
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EFFECT OF MICROTUBULE-TARGETING AGENTS ON STRUCTURAL SIGNALING AND CHEMICAL TRANSPORT IN CELLS
… of cell morphology and cell motility. Structurally, microtubules are formed by αβ-tubulin heterodimers that polymerize in a head-to-tail fashion to create protofilaments, which subsequently assemble into hollow cylindrical polar filaments. Microtubules’ behavior and function depend on …
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Structural characteristics and functional consequences of lateral ankle sprains
… of interventions. This thesis aims tostudy the structural characterisation and functional consequences of lateral ankle sprain.Three studies were undertaken. The first study used ultrasound to characterise and compare selected ankle structuresbetween healthy (n=48), coper (n=22) and chronic …
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Identification of quantitative second-harmonic generation imaging metrics for collagenous tissue
… of the 3D stack. This work revealed the 3D structural variation and the underlying helicity in the crimp patterns. In another study, I applied quantitative 3D-SHG imaging of collagen fibers to assess potential damage induced by electron-beam (e-beam) irradiation from environmental-scanning …
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Enzyme Architecture and Flexibility Affect DNA Topoisomerase I Function
… of Top1 that enables linker flexibility and the structural alterations that accompany drug binding of the covalent enzyme-DNA complex. In vitro studies of the corresponding human mutant, hTop1G717 D, showed that this mechanism of increased sensitivity is conserved. However, by expressing …
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Later Life Consequences of Subteratogenic Exposure to a Complex PAH Mixture in the Atlantic Killifish (Fundulus heteroclitus)
… individual PAHs and PAH mixtures cause heart alterations with decreased swimming capacity in adult fish. Consequently, the heart and cardiorespiratory system are thought to be targets of PAH mixture exposure. While many studies have investigated acute, teratogenic PAH exposures, few studies …
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Strategies for Oncogenesis by Avian Leukosis Viruses
… adjacent to the c-myc locus, without gross structural alteration of c-myc. The long terminal repeat (LTR) of an ALV provirus is integrated upstream of the bulk of ALV coding sequences in both tumors, and is oriented such that transcription could initiate within the LTR and continue …