Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"stromal-epithelial interactions"”.
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Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… I established a co-culture model consisting of epithelial cells and genetically locked myCAFs or iCAFs to study the link between the TME and the gene regulatory machinery in PDAC through genomic and proteomic approaches. This work identified STAT1 as a mediator of iCAF-induced transcriptional …
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Molecular mechanisms regulating implantation
… Recent evidence also points to the fact that stromal-epithelial interactions are critical for a successful implantation. To understand the mechanisms governing these complex interactions and better address the clinical challenges to infertility, it is important to integrate the information …
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Use of fourier transform- infrared spectroscopic imaging as a tool for understanding early molecular events driving breast cancer progression
… TGFβ1, co-culture with MCF-7 tumorigenic breast epithelial cells, and co-culture with MCF10A normal breast epithelial cells in trans-well co-culture and also three-dimensional cell culture. α-SMA expression was determined using immunofluorescence and the samples were surveyed in a holistic and …
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Systems pathology: a bottom-up approach for understanding fibroblast-epithelial interactions in breast cancer
… easily applied tool for investigating fibroblast-epithelial communication in a physiologically-relevant context. The 3D co-culture system was used to investigate how fibroblasts impact the growth of estrogen receptor-positive (ER+) breast cancer cells and this is described in chapter three. ER+ is …