Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 273 for “"stromal cells"”.
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Diversity among monocyte derived stromal cells
Fibrocytes are monocyte-derived cells that morphologically look like fibroblasts, express both stromal and haematopoietic markers, and have been reported as being involved in wound healing and fibrosis. In-vitro derived fibrocytes can be differentiated in both serum-containing and serum-free …
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Exogenous mesenchymal stromal cells in osteochondral repair
… than are currently available today. Mesenchymal stromal cells (MSCs) are adult-derived, multipotent cells which have immunomodulatory effects, and can differentiate into a variety of cell types, including cartilage progenitor cells, making MSCs a candidate for musculoskeletal cell therapy. …
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… This is largely due to the presence of dense stromal fibrosis which distorts tumour vasculature. This limits nutrient, oxygen and chemotherapy perfusion into pancreatic tumours and promotes oxidative stress. The craftsmen of fibrosis are cancer-associated pancreatic stellate cells (CA-PSCs) …
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Mesenchymal stromal cells in malignant glioma - Functions and therapeutic potential
… GBM is its infiltrative growth. As the tumor cells leave the tumor bulk and migrate into the normal brain parenchyma, it is impossible to reach them with the current standard treatments. Hence, even after treatment, some tumor cells will remain in the brain and eventually give rise to a new …
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Investigating the role of PKC-β in tumour activated stromal cells
… provides protective niches in which tumour cells receive survival signals promoting drug resistance. The Ringshausen lab have previously shown PKC-β to be a bone marrow stroma cell (BMSC) - autonomous signalling pathway critical for survival of malignant B-cells. PKC-β dependent cell contact …
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The recruitment of stromal cells to the site of tumor formation
… and induce the incorporation of a-SMApositive cells. We show that the expression in MCF-7-Ras modified human breast cancer cells of VEGF164, but not CXCL1 or CCL5, results in the promotion of primary tumor growth and the increased incorporation of [alpha]-SMA-positive cells. Furthermore, we …
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Tissue Engineering the TMJ Condyle using Human Umbilical Cord Mesenchymal Stromal Cells
… to this thesis, human umbilical cord mesenchymal stromal cells (hUCMSCs), identified as multipotent cells only in this decade, had not yet been used for TMJ tissue engineering. Hence, this thesis proposed a revolutionary tissue engineering approach in which hUCMSCs and mature hyaline cartilage …
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Bionanoparticles as Viable Substrates to Promote Osteogenic Differentiation of Bone Marrow Stromal Cells
<p>Bone marrow stromal cells (BMSCs) have the potential to differentiate into osteoblasts, chondrocytes, adipocytes and smooth muscles. Although, they have shown great prospects in therapeutic and medical applications, less is known about the role that the nano environment plays on their …
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Modulation of the osteoblastic differentiation of marrow stromal cells for bone tissue engineering
… the osteoblastic differentiation of marrow stromal cells (MSCs). The effects of an in vitro generated ECM on MSC osteoblastic gene expression under static culture indicated that MSCs differentiated down the osteoblastic lineage evidenced by significant increases in expression of the …
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The Role of Mesenchymal Stromal Cells in Inflammation and Treatment of Pulmonary Fibrosis
… to determine the method of action of mesenchymal stromal cell immunomodulation, and their potential benefits in treating pulmonary fibrosis. This was achieved through a series of in vitro studies and an in vivo model of lung disease, namely, bleomycin induced pulmonary fibrosis. Firstly MSC …
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The role of stromal cells in the establishment of Glioblastoma tumour microenvironment immunosuppression
… immunosuppressive phenotypes and secretions of cells within the tumour microenvironment (TME). The TME comprises a mixture of malignant tumour cells, stroma, blood vessels and infiltrating immune cells. Most attempts to alleviate immunosuppression focus on the contribution of T cells, microglia, …
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Application of Fluid Flow for Functional Tissue Engineering of Bone Marrow Stromal Cells
… scaffold, pharmaceutics, and osteoprogenitor cells. One source of osteoprogenitor cells is bone marrow stroma, which can be obtained from the patient - minimizing the risk of an immune response - directed in vitro to proliferate, and differentiate into a bone-like tissue. To date, tissue …
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Mcp-1 Release Modulation Through Interaction of Pulmonary Endothelial Cells and Mesenchymal Stromal Cells
… cell-based therapies such as mesenchymal stromal</p> <p>cells (MSCs) have increasingly shown great promise for ischemic stroke recovery</p> <p>with some therapies already in various stages of clinical trials. Intravenous (IV)</p> <p>administration of the MSCs leads to the entrapment of …
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Extracellular Vesicles to Evaluate the Effects of Mesenchymal Stromal Cells in the Premature Lung
… without effective treatment. Mesenchymal stromal cells (MSCs) improve features of experimental BPD, such as lung function, structure, and inflammation. The HULC-1 trial assessed the safety of MSCs for BPD. Since MSC mechanisms in the premature lung remain unclear, we hypothesized that …
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Development of Jetting Techniques for the Delivery of Mesenchymal Stromal Cells for Therapeutic Applications
Mesenchymal stromal cells (MSC) are an important cell source for tissue engineering and regenerative medicine (TERM) and cell therapies. Intravenous injections (I.V.) injections and scaffold implantation are currently the predominant methods of MSC administration. However, both approaches have …
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Pain alleviating effects of mesenchymal stem/stromal cells and derived extracellular vesicles in osteoarthritis
… for new therapies for OA, mesenchymal stem cells (MSCs) and derived extracellular vesicles (MSC-EVs) have led to promising therapeutic outcomes such as joint function improvement and pain relief. Whether the observed pain relief effects of MSCs and MSC-EVs originate from the direct effect on …
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The Impact of Adipose-Associated Stromal Cells on the Metastatic Potential of Ovarian Cancer
… on adipose tissue-derived stem and progenitor cells, which have previously been shown to be recruited by cancer cells and participate in cancer progression. We confirmed that ovarian cancer tumor burden was indeed significantly increased in mice on a high fat as compared to low fat diet. To …
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Sphingosine-1-Phosphate and Stromal Cells Contribute to an Aggressive Phenotype of Ovarian Cancer
… we investigate the impact of S1P on ovarian cells and their interactions with the stromal vascular fraction recruited from the adipose tissue in culture conditions that mimic the physiologic environment of the peritoneal cavity. These studies will provide a mechanistic link of obesity, …
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Mobilization of Adipose Stromal Cells In Obesity and Cancer By Sparc and Its Proteolytic Isoforms
… pathophysiology remained unclear. Adipose stromal cells (ASC) are adipose tissue-derived mesenchymal progenitors, abundant in white adipose tissue (WAT). In this study, we show that the ASC pool is expanded in obesity and is associated with promoted tumor growth. Next, by using a chimeric …
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