Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"stress stimuli"”.
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Role of eosinophils in anaphylactic reactions related to hormonal alterations
… anaphylactic reaions represent non-specific stress stimuli,their primary symptomatology is intermingled with the secondary manifestations from stress stimulation.The chief aim of the present thesis is to demonstrate ,that a group of manifestations which bear the name mq of anaphylaxis or …
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Receptor-Mediated Hypertrophic Signaling Via Protein Kinase D and Histone Deacetylase 5 in Adult Myocytes
<p>Hemodynamic stress and neurohumoral signaling are common causes of cardiac hypertrophy. These extrinsic stress stimuli typically act on GPCR and induce a cascade of signal transduction to re-program terminally differentiated myocytes to grow in length or width. The compensatory hypertrophic …
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The unfolded protein response and HLA-B27 misfolding: implications for ankylosing spondylitis
… reticulum (ER) and subsequently relieves ER stress by increasing the folding capacity of the ER. The secretory pathway substrate HLA-B27 is highly associated with the chronic inflammatory disease ankylosing spondylitis (AS) and has a tendency to misfold in the ER. Here, we show that …
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RNA modifications and processing in cell homeostasis and in response to oxidative stress
… normal conditions and in response to oxidative stress, and (2) to investigate the importance of Srsf2 in stem cells using skin as a model system. In the context of RNA modifications, firstly I described how NSun2-expressing cells enrich for transcripts related to enhanced cell survival. …
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Biochemical and physiological analysis of microvesicle subtypes
… and released sMVs rapidly in response to a stress stimuli. Analysis of calcium homeostasis has revealed that MVs contain high calcium levels, that are deliverable to cells via MVs as cargo. Furthermore, the MV subtypes express different arrays of deliverable proteins and receptors that were …
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Flower Isoforms Increase Expression in Response to Cellular Stress and Modulate S100 Expression in Cutaneous Squamous Cell Carcinoma Cells
… to normal skin. Exposure of cSCC cells to stress stimuli including ultraviolet irradiation, serum starvation, reactive oxygen species, or 5-fluorouracil increased hFWE expression, suggesting hFWE may be involved in the cellular stress response. Taken together, these results document a …
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Novel Aspects of the Response to Cellular Stress and Intracellular Bacterial Pathogens
The cellular stress response represents an essential mechanism that enables cells to adapt to an array of environmental and physiological conditions. Given the importance of these adaptive responses, it comes as no surprise that dysregulation of the stress response has been strongly implicated in …
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Caspase-dependent Signaling as an Inductive Cue for Cardiac Hypertrophy
… ability to adjust in response to varying stress stimuli and myocardium enlargement, referred to as cardiac hypertrophy, is a common form of stress adaptation. Divergent forms of hypertrophy can occur depending on the type and duration of the insult. The beneficial physiological form of …
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Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance
… and potential as therapeutic targets in disease. Stress granules (SG) are membrane-less ribonucleoprotein condensates that form in response to various stress stimuli via phase separation. SG act as a protective mechanism to cope with acute stress, but persistent SG have cytotoxic effects that are …
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Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI
… brain – which is highly vulnerable to various stress stimuli, resulting in increased brain swelling, disrupted cerebral blood flow (CBF) autoregulation, long-term disabilities and death following TBI in young demographic. Unsurprisingly, BBB disruption and the resultant cerebral edema have …
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The role of SENSITIVE TO FREEZING6 in plant tolerance to stress
… subject to increasing extremes of enviro nmental stress. Rapid population increases in developing countries also demand higher yield from crop production, often from sub-optimal agricultural areas. Genetic engineering can help meet these needs through the development of crops with greater stress …
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COMPUTATIONAL MODELING OF BACTERIAL OUTER MEMBRANES AND DEVELOPMENT OF HIGH-THROUGHPUT SCREENING PLATFORM FOR ANTIBIOTICS
… of how bacteria adapt to the chemical stress stimuli. The development of antimicrobial resistance is especially true for Gram-negative bacteria that develop resistance to antibiotics readily due to their unique highly charged outer membrane. Structurally, the Gram-negative bacteria is …
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Characterisation of the eukaryotic initiation factor 2alpha kinases of Plasmodium falciparum
… related apicomplexan parasite Toxoplasma gondii, stress stimuli have been implicated in an important differentiation step, from rapidly dividing tachyzoites, to quiescent bradyzoites (which enable immune evasion). Evidence suggests that stress may also contribute to an essential differentiation …
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Autophagy in Zellweger Syndrome Spectrum Disorder and Cancer
… at low basal levels, and can be upregulated by stress stimuli to promote cellular homeostasis. In this work, we investigated two aspects of autophagy regulation and relevance to human diseases. First, we examined how autophagy selectively removes viral components and damaged mitochondria from …
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Ruolo della TDP-43 nella formazione dei granuli da stress nella Sclerosi Laterale Amiotrofica
… Recent studies suggest that TDP-43 may regulates stress granules dynamics that are cytoplasmic structures composed of non-translating messenger ribonucleoproteins (mRNPs) that rapidly aggregate in cells exposed to adverse environmental conditions. Stress granules function in part to triage RNA and …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… innervate the site of infection. Any cellular stress trigger, ranging from external stimuli such as UV radiation or nerve injury to psychological and physiological stress, can reactivate HSV from latency in the neurons, resulting in recurrent disease episodes. Stress hormones and deprivation of …
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Effetto pro-ossidante e pro-infiammatorio degli ossisteroli in cellule intestinali: attività modulatoria della frazione fenolica del vino
… of the intestinal epithelium to oxidative stress and in the capability of nutritional antioxidants to strengthen endogenous antioxidant defenses. Among dietary-derived antioxidants, phenolic compounds have been described to have a wide range of biological activities and many reports have …