Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"stress sensing"”.
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Rotation and torsional stress sensing via coherent optics
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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Nanocomposite Coating Mechanics via Piezospectroscopy
… effect of alpha alumina could enable on the fly stress sensing for structural health monitoring applications. While the PS effect has been historically utilized in several applications, here by distributing the photo-luminescent material in nanoparticle form within a matrix, a stress sensing …
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Metabolic regulation of mammalian cell growth and proliferation
… until cells enter S phase, when the replication stress response becomes critical for cell survival. Moreover, we found that replication stress sensing promotes nucleotide availability during normal S phases, suggesting that proliferating cells enter S phase without sensing whether they have …
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Post-translationally Modified Glucocorticoid Receptors and Protein Tyrosine Kinase 6 Modulate Triple Negative Breast Cancer Phenotypes
… of GR in response to local or cellular stress. Specifically, we propose that GR acts as a “sensor” for stress signaling pathways commonly activated by soluble factors that are abundant within the tumor microenvironment (TME) of TNBC. Herein, we show that in the absence of GR ligands, GR …
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Regulation of mammalian IRE1α: Co-chaperones and their importance
… of IRE1, a conserved transmembrane ER stress receptor. Despite significant research, the mechanism of coupling ER stress to IRE1 oligomerisation and activation has remained contested. There are two proposed mechanisms by which IRE1 may sense accumulating unfolded proteins. In the direct …
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Elucidating how mutations in EIF2AK4 cause pulmonary vascular disease
… years if untreated. Biallelic mutations in the stress sensing kinase, EIF2AK4 (GCN2), are the main genetic cause of PVOD. I hypothesised that loss of GCN2 may lead to a pro-inflammatory phenotype which could be contributing to the development of PVOD. PVOD was modelled using mice with homozygous …
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Deciphering the role of Hsp31 as a multitasking chaperone
… neurons in substantia nigra. Cellular stresses such as accumulation of high level of reactive oxygen species, mitochondrial dysfunction and α-syn aggregation lead to toxicity and neuronal cell death in Parkinson’s disease patients. Mutations in certain genes are also involved in the …
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Mechanisms Of Presynaptic CaV2 Calcium Channel Localization In Caenorhabditis Elegans
… protein biogenesis with endoplasmic reticulum stress, and provides insights into the regulation of pathogen resistance by the endoplasmic reticulum stress-sensing pathway.</p>
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Stress-signal recognition in the unfolded protein response
… mechanisms in the UPR are well characterised, sensing of the unfolded protein load in the ER is incompletely understood. It is widely accepted that the key UPR transducer – IRE1 – responds to the unfolded protein burden by dimerisation/oligomerisation-dependent activation, however, the …
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Grapesystress: Use of systems biology and new breeding technology approaches to study water stress-resistant in grapevine plants.
… with increased frequency and duration of water stress posing significant threats to grape production in Mediterranean climates. These challenges will be compounded by heightened pest pressure and crop loss. Even though irrigation systems will expand worldwide, they will still not be sufficient …
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Delivery, design, and mechanism of antimicrobial peptides
… these visual observations with various membrane stress sensing mechanisms. We concluded that bacteria's ability to develop resistance to ponericin G1 requires the sensing and repair of misfolded membrane proteins via the CpxAR system, as well as DNA repair via induction of the SOS response by …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… axes through which distinct metabolic stressors reprogram immune cell fate.</p> <p>The first centers on how obesity-driven noncoding RNA dysregulation suppresses NK cell fitness and renders cellular immunotherapy ineffective. To identify circulating mediators of obesity-associated …
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Controlling and Exploiting Spiropyran-based Mechanochromism
… explored for a variety of purposes, including stress sensing, stress</p><p>strengthening, small molecule release, catalysis, and development of soft devices.</p><p>Additionally, the effect of force on a reaction coordinate, through biasing and probing</p><p>reaction pathways and trapping of …
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Discovery of an extracellular stress sensory protein in Beauveria bassiana and identification of photolyase encoding phr-1 sequences in five entomopathogenic fungi
… of the mechanisms of response to environmental stresses and conditions. An aspect of repair of ultraviolet radiation induced DNA damage and response to high temperature were studied here. A region of the photolyase gene (phr-1), encoding cyclobutane pyrimidine dimer photolyase (CPD-PHR), an …