Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"stress granules (SGs)"”.
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AGGREGATION MECHANISMS OF TDP-43 PROTEIN IN RESPONSE TO STRESS IN AMYOTROPHIC LATERAL SCLEROSIS AND THERAPEUTIC APPROACHES
… POLDIP3. We demonstrated that chronic oxidative stress in these cellular models induced TDP-43 cytoplasmic mislocalization and defective TDP-43 splicing activity, thus recapitulating both TDP-43 proteinopathy features. Since we observed dysregulated gene expression of autophagy and senescence …
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Investigating pathological mechanisms in the Thy1-hTDP43 ALS mouse model
… common link, causing the generation of cellular stress. The generation of cellular stress induces the activation of many protective mechanisms, such as the formation of stress granules (SGs). SGs are typically transient structures that sequester translationally-stalled mRNA, RNA-binding proteins, …
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Molecular Mechanisms of Host Responses to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection
… to evaluate the ability of the virus to induce stress granules (SGs) during PRRSV infection. SGs are intracellular, cytoplasmic aggregates of RNA-binding proteins (RBPs) and mRNA. Formation of SGs is observed upon cellular stress and ultimately function to arrest cellular translation to promote …
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Cellular responses to external threats probed by super-resolution microscopy
… granular aggregates called as antiviral granules (AVGs). We infected/transfected cells by influenza virus lacking NS1 (IAVΔNS1) or polyinosinic:polycytidylic acid (poly I:C) to induce AVGs. We found in AVGs, RIG-I forms clusters of around 110nm in diameter. Then we treated intact cells …
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Defining the Cellular and Molecular Basis of Spondyloepiphyseal dysplasia tarda
… COPII inner coat, take part in the integrated stress response (IRS). Upon perturbations that change cellular homeostasis such as heat shock, redox stress or unfolded protein accumulation, cells activate signalling pathways that result in translation inhibition by sequestering free mRNAs and …
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RNA binding proteins in neurotoxic protein clearance
… neurotoxic proteins, and an increase in cellular stressors such as reactive oxygen species – eventually causing neuronal cell death. In the case of PD, neuronal inclusions are composed primarily of the small, disordered protein alpha synuclein (α-Syn), which can be an autophagy substrate. To …
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Modulation of Stress Granules formation: Role of mGlu5 receptor and FMRP and implications for pathophysiology of Fragile X Syndrome
… role of FMRP in mRNA metabolism as component of stress granules (SGs) has been identified. FMRP seems to lead mRNAs in SGs upon cellular stress, during which protein synthesis is blocked. SGs are ribonucleoproteic aggregates containing translation initiation components and RNA binding proteins, …