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Showing 1 to 20 of 42 for “"stress granules"”.

  1. Characterizing unique features of prion-like domains recruited to stress granules

    Baer, Matthew Henry, author, Ross, Eric D., advisor, Stasevich, Timothy J., committee member, Zabel, Mark D., committee memberColorado State University. Libraries2021

    … of assembly-propensity, where localization to stress granules is modulated by differences in residue composition of the domains. To measure the different degrees of assembly propensity of PrLDs, we developed a novel means of quantitative image analysis to determine the enrichment of PrLDs in …

    colostate Repository record

  2. STRESS GRANULES MODULATE SYK TO CAUSE MICROGLIAL DYSFUNCTION IN ALZHEIMER’S DISEASE

    Ghosh, Soumitra

    … our lab indicates that SYK can associate with stress granules, ribonucleoprotein particles that form in stressed cells and contain inactive translation initiation complexes. I found that microglial cell lines and primary mouse brain microglia, when stressed by exposure to sodium arsenite or …

    purdue-thes Repository record

  3. Sam68, Stress Granules, and translational control of HIV-1 nef mRNA

    Henao-Mejia, Jorge Alejandro2009

    … to form a macromolecular structure called stress granules (SG). In addition, we demonstrated that these variants bound to nef mRNA in a sequence-specific manner. Furthermore, we showed that these variants co-localized with nef mRNA in SG. Importantly, we validated these findings in the …

    iupui Repository record

  4. ALS-related TBK1 mutations alter the formation of stress granules in motor neurons

    Erfle, ValerieUniversität Ulm

    ulm-diss Repository record

  5. Parallels and Divergences in Multisystem Proteinopathy Genes: Stress Granules, Autophagy, and Myogenic Deficits

    Pontifex, Carly SabineGraduate Studies2025

    … this, we examined three areas of interest: stress granules, autophagy, and myogenesis. The currently identified roster of MSP genes have several structural and functional commonalities which fall into two categories: LC3B-intracting domain containing autophagy adaptors (SQSTM1, VCP, OPTN) …

    calgary Repository record

  6. Role of Syk in the regulation of cytoskeleton and stress granules in breast cancer

    Krisenko, Mariya

    … partners also found to be recruited to stress granules. Treatment of cells with inducers of stress granule formation leads to the recruitment of Syk to these protein-RNA complexes. This recruitment requires the phosphorylation of Syk on tyrosine and results in the phosphorylation of …

    purdue-thes Repository record

  7. TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor

    Dewey, Colleen Marie2012

    … suggests that TDP-43 associates with cytoplasmic stress granules, which are transient structures that form in response to stress. In this study, we establish sorbitol as a novel stressor that directs TDP-43 to stress granules in Hek293T cells and primary cultured glia. We quantify TDP-43 …

    utswmed Repository record

  8. Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance

    Lee, Anna Kunyoung2022

    … and potential as therapeutic targets in disease. Stress granules (SG) are membrane-less ribonucleoprotein condensates that form in response to various stress stimuli via phase separation. SG act as a protective mechanism to cope with acute stress, but persistent SG have cytotoxic effects that are …

    utswmed Repository record

  9. The NTF2L Domain Is a Date Hub That Interacts with SLiMs to Regulate Assembly of Stress Granules

    Wu, Jinjun2028

    … take a prototypical biomolecu- lar condensate, stress granule (SG), as an example to illustrate how the interactions between SLiMs and date hubs contribute to the interaction networks that drive biomolecular con-densation.</p> <p>We firstly confirmed that the NTF2L domain of G3BP1 protein, the …

    tenn-hsc Repository record

  10. Modulation of Stress Granules formation: Role of mGlu5 receptor and FMRP and implications for pathophysiology of Fragile X Syndrome

    DI MARCO, BARBARAUniversità degli studi di Catania2014

    … role of FMRP in mRNA metabolism as component of stress granules (SGs) has been identified. FMRP seems to lead mRNAs in SGs upon cellular stress, during which protein synthesis is blocked. SGs are ribonucleoproteic aggregates containing translation initiation components and RNA binding proteins, …

    catania Repository record

  11. Ruolo della TDP-43 nella formazione dei granuli da stress nella Sclerosi Laterale Amiotrofica

    CONI, PAOLAUniversità degli Studi di Cagliari2016

    … Recent studies suggest that TDP-43 may regulates stress granules dynamics that are cytoplasmic structures composed of non-translating messenger ribonucleoproteins (mRNPs) that rapidly aggregate in cells exposed to adverse environmental conditions. Stress granules function in part to triage RNA and …

    cagliari Repository record

  12. The Interaction Between Host G3BP and Viral Nucleocapsid Protein Regulates SARS-CoV-2 Replication

    Yang, Zemin2025

    … proteins that promote condensation to form stress granules in response to various cellular stresses, including viral infection. G3BP1/2 are prominent interactors of the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the functional …

    tenn-hsc Repository record

  13. Mechanisms of dynein-based mRNA transport processes in human cells

    Andres Jeske, YaizaUniversity of Cambridge2023

    … motor. As FXR1 and FXR2 are highly enriched in stress granules – large RNPs that sequester mRNAs when cells receive an insult – this thesis also explores the role of the dynein-BICD2 complex in the assembly of these structures. For this purpose, biochemical assays, as well as fixed and live cell …

    cambridge Repository record

  14. Investigating pathological mechanisms in the Thy1-hTDP43 ALS mouse model

    Ridgway, Zara LillyThe University of Edinburgh2025

    … common link, causing the generation of cellular stress. The generation of cellular stress induces the activation of many protective mechanisms, such as the formation of stress granules (SGs). SGs are typically transient structures that sequester translationally-stalled mRNA, RNA-binding proteins, …

    edinburgh Repository record

  15. Characterization of the instability elements present within the 3' UTR of the glutaminase mRNA in WKPT kidney cells

    Lee, Yeon Jean, author, Curthoys, Norman P., advisor, Bamburg, James R., committee member, Laybourn, Paul, committee member, Suchman, Erica, committee member, Wilusz, Jeffrey, committee memberColorado State University. Libraries2006

    … phospho-eIF2α and ζ-cryst may co-localize in stress granules. The treatment of WKPT-ζ+ cells with pH 6.9 medium activated the ER stress signaling pathway and resulted in the initial, but transient, association of ζ-cryst with stress granules. The completed experiments demonstrated the …

    colostate Repository record

  16. An investigation of proteoforms in health and disease using peptide-level readouts

    Moggridge, Sophie2025

    … in response to osmotic, heat, and oxidative stresses. We identify shared and stress-type specific phosphorylation signatures that align with previously reported data. We also identify phosphorylation sites on proteins known to localize to stress granules, providing a candidate list of stress …

    washington Repository record

  17. mRNA localization in Caenorhabditis elegans embryogenesis

    Parker, Dylan M., author, Osborne Nishimura, Erin, advisor, Ben-Hur, Asa, committee member, Montgomery, Tai, committee member, Stasevich, Tim, committee member, Santangelo, Tom, committee memberColorado State University. Libraries2021

    … that many well-studied mRNA foci, such as germ granules, P-bodies, and stress granules, do not follow the lock-and-key principle of stoichiometric complex formation, but are actually phase-separated, biomolecular condensates. Due to their liquid-like nature, biomolecular condensates can …

    colostate Repository record

  18. Kap-[beta]2 Recognition of Cargoes Involved in Neurodegenerative/Neurodevelopmental Diseases

    González Castro, Abner Josué2025

    … mutations cause mislocalization of the cargo to stress granules in the cytoplasm. I performed biophysical and structural studies and found that the HNRNPH2 has a new type of epitope not observed before. Furthermore, I observed that this new epitope is essential for HNRNPH2 recognition. These …

    utswmed Repository record

  19. Identifying novel proteins in translation complex by using analytical ultracentrifugation with fluorescent detection system

    Zhang, Chongxu

    … had previously been shown to be a component of stress granules formed following glucose depletion and SLF1 to be associated with translational process. PUB1 could bind to ARE and STE sequence. SUP35 was also reported in the 80S translation complex in 2008. SSD1 had a global effect on …

    unh-thes Repository record

  20. Regulation of exogenous retroviruses and endogenous retroelements by MOV10

    Arjan-Odedra, ShetalKing's College London2013

    … in cytoplasmic mRNA processing bodies and stress granules. Considering MOV10 cellular associations and homolog functions, the capacity of MOV10 to regulate the replication of a diverse panel of genetically distinct retroelements was investigated here.<br/>Ectopically overexpressed MOV10 …

    kings Repository record

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