Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"stress fibers"”.
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Mechanisms of Actomyosin Contractility in Cells
… to divide the cell during cytokinesis, and the stress fiber, which is anchored to the extracellular matrix and allows the cell to exert contractile forces on its surroundings. In the first part of the thesis, we develop a mathematical model to characterize the constriction mechanism of …
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Role of Sodium Arsenite in Atherogenesis
… in reorganization of actin filaments into stress fibers and non-uniform VE-cadherin and β-catenin staining at cell-cell junctions. Intercellular gaps were observed with a measured increase in endothelial permeability. In addition, an increase in tyrosine phosphorylation (PY) of β-catenin …
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Role of Sodium Arsenite in Atherogenesis
… in reorganization of actin filaments into stress fibers and non-uniform VE-cadherin and β-catenin staining at cell-cell junctions. Intercellular gaps were observed with a measured increase in endothelial permeability. In addition, an increase in tyrosine phosphorylation (PY) of β-catenin …
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A study on the modulation of alpha-actinin and filamentous actin
… inhibits bundling of actin filaments into stress fibers in epithelial cells. I show that α-actinin-4 accomplishes this by inhibiting tropomyosin dependent stabilization of filamentous actin, and maintains a dynamic basal actin array through promoting actin disassembly. Lastly I demonstrate …
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The Impact of substrate texture on cell behavior
… cell, nucleus and architecture of force-bearing stress fibers of the actin cytoskeleton are all highly dependent on the stripe width. 3D confocal measurements showed that the cell thickness and nuclear shape is regulated through the different arrangement of perinuclear actin stress fibers …
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Molecular interactions of talin and actin: a study on the specific domains of talin involved in the interactions
… ABS1 were primarily colocalized with actin stress fibers when transfected into COS cells, whereas EGFP-ABS3 was predominantly colocalized with actin-rich membrane ruffles.;The ABS2 and ABS3 within the C-terminal tail were further defined to residues 1051--1250 (ABS2) and 2331--2530 (ABS3), …
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Activated EphA4 receptor in <i>Xenopus laevis</i> acts rhrough src- like tyrosine kinase p59fyn to inhibit RhoA GTPase
… loss of cell adhesion, tight junctions, and stress fibers. Previous studies revealed that these receptors achieve their cellular effects at least in part by inhibiting RhoA GTPase. However, what links these GTPases with the EphA4 receptor remained unknown.</p> <p>In an attempt to investigate …
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Characterization of perillyl alcohol as a cell migration-inhibiting compound
… involved in the formation of focal adhesions and stress fibers, and corresponding morphological changes following exposure to perillyl alcohol.
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INTERRELATIONSHIP BETWEEN CONTRACTILITY AND DYNAMICS OF ACTOMYOSIN SYSTEM IN NON-MUSCLE CELLS
… incorporation-dissociation driven flow along the fibers) and myosin dependent contractility are related to each other in matured ventral stress fibers (VSFs) still remains elusive. To this end, I manipulated either actin incorporation or forces to investigate their effects. Surprisingly, SMIFH2 …
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Regulation of Inverted Formin-1 (INF1) by Microtubule-Affinity Regulating Kinase 2 (MARK2)
… that INF1’s ability to induce F-actin stress fibers and activate SRF is inhibited by Microtubule-Affinity Regulating Kinase 2 (MARK2). Inhibition of INF1’s actin polymerization activity by MARK2 likely occurs near INF1’s C-terminus. However, MARK2 was unable to inhibit INF1’s ability to …
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Identification of Actin Binding Proteins Associated with Cross-Linked Actin Networks
… cytoskeleton rearrangements from linear actin stress fibers to cross-linked actin networks and the position of candidate proteins in relation to CLANs. Dexamethasone treatment of TM cells altered the expression of actin-associated proteins that may be important in the formation of CLANs and …
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Stress Fiber Formation and Migration Are Novel PGR-Dependent Pathways Initiated in the Granulosa Cells of the Ovulating Follicle
… ‘formation of actin filaments’ and ‘formation of stress fibers’ as primary pathways. In contrast, RNA-seq analysis of the ovarian stromal compartment found minimal PGR-dependent regulation of stromal genes. It was then established that in response to ovulatory stimulus, thick actin stress fibers …
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Regulation of the Cytoskeleton by Kinesins
… increases the number of focal adhesions and stress fibers and results in defects in cell spreading. KIF2A does not influence the dynamics of focal adhesion assembly or disassembly. In contrast, depletion of KIF2C prevents re-formation of focal adhesions. has little or no effect on the actin …
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The Cytoskeletal Mechanisms of Cell-Cell Junction formation in Endothelial Cells
… recruit nonmuscle myosin II and mature into stress fibers. Myosin II activity was important for bridge formation and accumulation of VE-cadherin in nascent adherens junctions. Our data reveal a mechanism of cell-cell junction formation in endothelial cells utilizing lamellipodia as the …
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An Investigation into the Role of Arf6 in MCH-mediated Rearrangements in 3T3-L1 Preadipocytes
… microscopy was used to visualize the actin stress fibers and morphology of the cell and a scratch wound was performed to determine if the migration rate was affected. Preliminary results from our fluorescence stain show that the structure of actin was affected by NAV-2729 after MCH addition, …
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P16/INK4a controls the morphology program associated with cellular senescence
… or upon exposure to various kinds of stress. The senescence program involves G1 arrest accompanied by dramatic changes in cell function and morphology. The molecular mechanisms that govern these changes are at this point only partly understood. <br>Results: We here demonstrate that the …
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Regulation of Cell Migration by WNK1
… including circular dorsal ruffles and stress fibers; 2. Activation of downstream effectors of phosphatidylinositol 3-kinase (PI3K), including Akt and LIMK1; 3. Regulation of proteins that control the cytoskeletal re-organization including the ERM proteins (Ezrin, Moesin, and Radixin), …
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The FP prostanoid receptor: Isoforms and functional studies
… There is concomitant formation of actin stress fibers and increased tyrosine phosphorylation of p125 FAK. Understanding the molecular mechanisms underlying the PGF₂(α) induced changes in the cell morphology and in the cell cytoskeleton may be relevant for developing better treatments for …
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The Effects of Acetylenic Tricyclic Bis-(Cyano Enone) on Cell Migration
… 374 of actin, inhibits actin polymerization and stress fiber formation. These findings were applied to a model of epithelial-to-mesenchymal transition, a precursor event to metastasis, where I determined TBE-31 was able to inhibit the crucial rearrangement of cortical actin to form actin stress …
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Cell Mechanics: From Cytoskeletal Dynamics to Tissue-Scale Mechanical Phenomena
… scales, such as muscle sarcomeres, actomyosin stress fibers, adherent cells. In part (b) I introduce a continuum mechanical model for cells adherent to two-dimensional extracellular matrix, and discuss how cells can sense mechanical and geometrical cues from its surrounding matrix. The model …
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