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Showing 1 to 20 of 98 for “"streptozotocin"”.
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Atrial natriuretic peptide and streptozotocin-induced diabetes in rats
… induced by intraperitoneal injection of 45 mg/kg streptozotocin in male Sprague-Dawley rats. After three weeks of established OM (glucosuria and blood glucose> 250 mg/dl), plasma irANP levels were 149.6 ± 19.4 pg/ml in the OM group (n = 18) and 86.3 + 12.9 pg/ml in the normal group en = 12, P …
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Urinary excretion of trace metals in the streptozotocin-diabetic rat
… trace metal excretion was examined in normal and streptozotocin-diabetic rats. Induction of the diabetic condition resulted in a rapid and persistent increase in the quantities of zinc, copper and iron lost in the urine daily. Diabetic rats excreted 3.4, 5.0, and 4.9-fold more zinc, copper and …
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Effects of streptozotocin diabetes on the noradrenergic innervation of the rat heart
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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A streptozotocin-induced model of Alzheimer's disease in mice with wild-type human tau
… using intracerebroventricular infusions of streptozotocin (ICV-STZ) in transgenic mice expressing human tau. The Barnes maze, a test of spatial learning and memory, and a panel of antibodies directed at biochemical changes in tau associated with AD were used to assess memory deficits and tau …
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The effects of ageing and streptozotocin (STZ) - induced diabetes mellitus on the rodent parotid gland
… study investigated the effects of ageing and streptozotocin (STZ)-induced diabetes on the structure and function of the rat parotid gland. Rats (2-6, 12, 16-18 and 22-24 months old) were obtained from a recommended Home Office supplier and diabetic rat models were achieved by employing STZ. …
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The Effect Of Streptozotocin-induced Diabetes And Thyroid Hormone Alterations On Skeletal Muscle Contractile, Histochemical And Biochemical Properties
… a reduced state through fifteen weeks of chronic streptozotocin (STZ)-induced diabetes. Daily supplementation of either 30, 50 or 75 ug/kg body weight of T3 to diabetic animals instigated a normal negative feedback response despite the diabetic state. These data would support the hypothesis that …
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Sex differences in mesenteric endothelial function of streptozotocin-induced diabetic rats: The role of endothelium-derived relaxing factors
… reactivity of mesenteric arteries taken from streptozotocin (STZ)-induced diabetic rats at early and intermediate stages of the disease (one and eight weeks, respectively). We also investigated the mesenteric expression of the mRNAs for endothelial nitric oxide synthase (eNOS) and NADPH …
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The effect of insulin treatment and exercise modality on skeletal muscle fiber size in streptozotocin-induced type 1 diabetic rats
Severe Type 1 Diabetes Mellitus (T1DM) is known to have several negative effects on skeletal muscle mass, a condition known as diabetic myopathy. One of these effects is the atrophy of the glycolytic muscle fibers. However, the role of intensity of insulin treatment and exercise modality in …
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Gender differences in aortic endothelial function in a rat model of streptozotocin-induced diabetes : possible role of superoxide and cyclooxygenase
… in the aortic endothelial function in · streptozotocin (STZ, 58 mg/kg, iv)-induced diabetic rats, and the potential role of superoxide and cyclooxygenase (COX) metabolites in diabetes-induced vascular dysfunction.</p>
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Therapeutic Effect of a triterpenic Acid from Protorhus longifolia Against High Fat Diet Fed and Streptozotocin-induced Diabetic Nephropathy in Rats
… (RA5), against high fat diet (HFD) fed and streptozotocin (STZ)- induced diabetic nephropathy in rats. RA5 was isolated from the chloroform extract of Protorhus longifolia stem bark. Chemical structure of RA5 was confirmed based spectral data analysis. The in vitro antioxidant activity of …
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Pengaruh pemberian ekstrak biji klabet (Trigonella foenum graecum L) terhadap kadar glukosa darah dan gambaran histologi pankreas mencit (Mus musculus) yang terpapar Streptozotocin
… (Mus musculus) diabetes yang diinduksi dengan streptozotocin. Kadar glukosa darah mencit diabetes kelompok perlakuan ekstrak biji klabet (dosis I,II,III) kembali normal sedangkan dosis optimum yang menurunkan kadar glukosa darah adalah dosis 2 (1,76 mg/ekor/hr). Perbaikan struktur islet …
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Biochemical differences in the modes of synaptic vesicle release between control and streptozotocin-induced diabetic rats and possible relationship to changes in behaviour
… that in diabetic terminals (prepared from streptozotocin treated rats: a model for type 1 diabetes), higher amount of K&R exocytosis occurs relative to non-diabetic terminals due to a higher stimulus evoked change in intracellular calcium. Whether this was due to an over-activation of …
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The effects of magnesium treatment on short-term changes in heart rate variability, ventricular function and lipid profile in streptozotocin-induced diabetic rats
… of Mg²⁺ treatment on the early manifestations of streptozotocin (STZ)-induced diabetic cardiac complications. METHODS: Adult male Wistar rats were treated once with STZ (50 mg/kg, i.p.) or vehicle (citrate), and daily for seven days with MgSO4 (270 mg/kg, i.p.) or saline. Blood glucose and body …
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Pengaruh ekstrak biji klabet (Trigonella foenum graecum Linn.) terhadap kadar enzim transaminase (GPT Dan GOT) dan gambaran histologi hepar mencit (Mus musculus) yang terpapar Streptozotocin
INDONESIA: Diabetes mellitus adalah penyakit gangguan keseimbangan hormon insulin yang ditandai dengan adanya peningkatan kadar glukosa darah. Diabetes mellitus dapat menyebabkan peningkatan radikal bebas. Radikal bebas ini dapat merusak berbagai jaringan tubuh termasuk sel hati. Kerusakan sel hati …
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Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
… media (CM) that promoted β-cell regeneration in streptozotocin-treated mice. Ductal-derived endocrine progenitors, which have been shown to generate β-cells following pancreatic injury, represent a candidate for the ‘signal-receiving cell’. Ductal (CK19+) cells from mice pancreata obtained by …
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Aspects of hormonal regulation of hepatic carbohydrate and lipid metabolism
… synthesis and was validated in control<br/>and streptozotocin diabetic rats* Hepatic glycogen recycling was low in<br/>fed adult rats but was apparently greater in foetal rats. The precursor<br/>source for glycogen synthesis in vivo could not be determined from the<br/>distribution pattern of 3H …
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Pengaruh air perasan bawang lanang (Allium sativum) terhadap kadar glukosa darah dan gambaran histologi pankreas pada mencit (Mus musculus) diabetes militus
… musculus) diabetes yang diinduksi menggunakan streptozotocin. Penelitian ini merupakan penelitian eksperimental dengan menggunakan Rancangan Acak Kelompok (RAK) dengan 5 perlakuan dan 5 ulangan, perlakuan yang digunakan adalah mencit kontrol negatif (tanpa perlakuan), mencit kontrol positif …
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Medicinal cannabis for neuropathic pain
… a CMT2A mouse model. Finally, a single high-dose streptozotocin-induced diabetic neuropathy mouse model was characterised to determine the parameters of peripheral neuropathy and neuropathic pain symptoms in male wildtype B6:D2 mice. A pure isolate of 12.5 mg/kg CBD showed the greatest efficacy in …
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Effects Of Sustained Release Somatostatin Type 2 Antagonism On Glucagon Counterregulation And Glycemia In Type 2 Diabetic Rate Model
… were placed on a high-fat diet and injected with streptozotocin to induce T2D. The rats were then chronically treated with varying doses of ZT-01 or vehicle using implanted mini-osmotic pumps. While ZT-01 did not significantly affect basal glucose levels or oral glucose tolerance, it tended to …
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