Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"stratum corneum"”.
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Electrical characterization of electroporation of human stratum corneum
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1994.
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The damaging potential of pesticide formulations on human skin
… Water permeation studies demonstrated stratum corneum damage due to emulsifiable concentrate formulations, damage being time and concentration dependent. The major excipient responsible was the divalent anionic surfactant Phenylsulphonate CA. Another divalent anionic surfactant Empicol …
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An investigation of the effect of surfactants on transdermal permeation.
… the direct effects of surfactants on the stratum corneum, and thus propose mechanisms of action for these compounds as penetration enhancers. The main methods used in the study were: determination of the permeability of neonatal rat stratum corneum to propan-2-ol; differential scanning …
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An investigation of in vitro percutaneous penetration enhancement of benzocaine by azone, dimethylsulfoxide, and 2-pyrrolidone
… by directly reducing the barrier function of the stratum corneum. DMSO-induced enhancement of benzocaine penetration was observed over 40/80% V/V DMSO. Pretreatment studies strongly suggested that enhancement by DMSO is due to a significant but temporary effect on the epidermal barrier. The …
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Capturing skin properties from dynamic mechanical analyses
… at different locations on the arm and hand, when stratum corneum hydration was varied by controlled changes in environmental humidity, and following the application of film-forming polymers. Parallel measurements were made with the Cutometer® so that the two devices could be compared. The findings …
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Improved Estimation of Transport Parameters in the Dermis
… 16 kDa. When combined with existing models for stratum corneum permeability and appropriate measures of tissue binding, the developed model has the potential to significantly improve tissue concentration estimates for large or highly protein bound permeants following dermal exposure.</p><p>The …
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Mechanisms of chemical and physical transdermal penetration enhancement
… process between drug, enhancer and vehicle in stratum corneum (SC) was examined. When enhancers were added to the applied formulations, CP diffusivity and solubility were significantly enhanced when compared to the neat propylene glycol (PG) application. Enhancers did not affect PG diffusivity …
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EVALUATION OF PHARMACEUTICAL AND COSMETIC USE OF EXCIPIENTS OBTAINED FROM CITRUS PROCESSING WASTE PRODUCTS
… ability to induce a conformational change in stratum corneum lipids, shifting them from an ordered configuration to a liquid-like organization upon penetration of BLCs. The hypothesis of perturbation of the stratum corneum lipid network was further demonstrated by a second set of in vitro …
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Optimisation of microneedle array design for microneedle mediated iontophoretic transdermal drug delivery
… of the uppermost layer of the skin, the stratum corneum must be sought. It has recently been suggested that a combination of microneedle (MN) and iontophoresis (ITP) technologies may broaden the range of macromolecules that may be successfully delivered across the skin, with the added …
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The development and evaluation of a hydrogel drug delivery system for dithranol.
… into aqueous media than into non-aqueous media. Stratum corneum, however, acts as a rate-limiting membrane so that the release rate became independent of receptor medium hydrophobicity. A rate constant of dithranol release from hydrogel through stratum corneum of 0.2 μg/cm2/hr was obtained. The …
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A computational model for transdermal diffusion of lidocaine and tetracaine topical patches
… of epidermis originate from low permeability of stratum corneum (SC) which is the outermost layer of the human skin. The objective of this thesis is to build a Finite Element (FE) model, utilizing commercial FE software (ANSYS), that can be implemented to estimate parameters of diffusion as well …
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A conformable ultrasound patch for cavitation enhanced transdermal cosmeceutical delivery
… is limited by the innate barrier function of the stratum corneum. Here, we report a conformable ultrasound patch (cUSP) that enhances transdermal transport of niacinamide by inducing intermediate-frequency sonophoresis in the fluid coupling medium between the patch and the skin. The cUSP consists …
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Vliv délky acylu ceramidů na permeabilitu kůže
… obsažené v nejsvrchnější vrstvě epidermis, stratum corneum (SC), jsou zodpovědné za bariérovou funkci kůže a tím i její propustnost pro léčiva. Jejich úloha při tvorbě kožní bariéry je detailně známa, do dnešní doby však není řádně prostudován vztah mezi jejich strukturou a aktivitou. …
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Kultivace kožních štěpů jako modelů pro výzkum bariérové funkce kůže
… by the uppermost layer of the epidermis, the stratum corneum (SC). The arrangement of the lipid layer surrounding keratinocytes is especially important for it. This is evidenced by the association between the increased incidence of skin diseases and the imbalance of present lipids. This thesis …
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Mechanistic investigation of skin barrier perturbation induced by surfactants in the presence of humectants
The stratum corneum (SC) of the skin functions as a barrier between the body and the environment. Surfactants such as Sodium Dodecyl Sulfate (SDS) are used in skin cleansers and in skin-care formulations because of their ability to stabilize oil-water emulsions and clean the surface of the skin. …
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Determinants of systemic treatment response in atopic dermatitis
… adolescents. Proteomic analysis of tape-stripped stratum corneum samples demonstrated reductions in inflammatory and barrier-related proteins, supporting molecular recovery and the feasibility of minimally invasive skin sampling. The third study assessed IL-13 blockade with tralokinumab in adults …
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Advanced optical microscopy toolkits for non-invasive imaging in oncology
… Raman scattering (CRS) imaging techniques in the stratum corneum, the most superficial layer of the epidermis; (3) using photoconvertible labels to optically tag cell sub-populations of interest in situ for long-term monitoring of heterogeneous cell cultures from in vitro monolayers to in vivo …
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Phonophoresis and topical drug delivery
… step of absorption was partitioning from the stratum corneum into the viable epidermis. Sonication did not accelerate this step.
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Polymer substrates with microneedles for epidermis injection
… the epidermis, rigid enough for puncturing the stratum corneum, but not weak enough to buckle or be brittle.
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