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Showing 1 to 20 of 26 for “"strain RB51"”.
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Expression and Localization of Green Fluorescent Protein in B. abortus strain RB51
… cattle and undulant fever in human. B. abortus strain RB51 (Strain RB51) is the official vaccine for bovine brucellosis in the USA. B. abortus strain RB51 can be used as a vector for the over-expression of its own (homologous) as well as heterologous protective antigens. The immune system can …
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The behavior and effects of Brucella abortus rough strain RB51 in mice and cattle
Brucella abortus st. RB51 is a rough mutant of smooth st. 2308 devoid of O-side chain and resistant to rifampin. The purpose of this investigation was to study the behavior and effects of viable st. RB51 organisms in inoculated mice and cattle and to further substantiate the lack of O-side chain …
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Immune mechanisms in murine brucellosis: studies with strain RB51, a rough mutant of Brucella abortus
… were investigated in this study.B. abortus strain 19, the current vaccine strain, is known to induce an antibody as well as cell mediated immune responses, both of which protect mice against smooth strain 2308. B. abortus rough strain RB51 does not induce an o-side chain specific antibody …
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Brucella abortus Strain RB51 Outer Membrane Vesicles as a Vaccine Against Brucellosis in a Murine Model
… cattle and causes brucellosis. B. abortus strain RB51 is a live, attenuated vaccine licensed for cattle. However, there is no available vaccine to prevent human brucellosis. Outer membrane vesicles have been tested as potential vaccines to prevent diseases caused by bacterial species. OMV …
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The ability of TLR agonists to upregulate Brucella abortus strain RB51 mediated protection in a murine respiratory model
… effective vaccine for humans. Brucella abortus strain RB51, approved for use in cattle, provides protection by initiating a strong T-helper 1 (Th1) type response is a candidate vaccine. Based on a model for aerosol exposure mice were vaccinated intranasally (IN) with strain RB51 and challenged …
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The Humoral Immune Response of Elks (Cervus elaphus nelsoni) and Mice to Vaccination with Brucella abortus Strain RB51
Vaccine Brucella abortus strain RB51, unlike the wild strain 2308 and another vaccine strain (strain 19) does not induce anti-O-chain antibodies. An efficacious vaccine strain that fails to produce an O-chain and thus a lack of an anti-O-chain humoral response greatly simplifies identification of …
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Induction of Protection, Antibodies and Cell Mediated Immune Responses by Brucella Abortus Strain RB51, Ochrobactrum Anthropi and Recombinants Thereof
… animal vaccines. In this research, B. abortus strain RB51 and a closely-related, nonpathogenic Ochrobactrum anthropi (strain 49237) bacterium were used to study the immune response against brucellosis in mice. Both O. anthropi strain 49237 and recombinant strain 49237 expressing Brucella …
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Development of Brucella abortus RB51 as a Vaccine to Protect Against Brucellosis and Anthrax
… protection against brucellosis. B. abortus strain RB51 has been shown to be useful in eliciting protective CMI and antibody responses against Brucella in cattle and other animal species. Since the protective antigen (PA) of B. anthracis is known to induce antibodies, the pag gene encoding PA …
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The pregnant mouse model of brucellosis: the pathology and protection studies comparing Brucella abortus strains 2308, 19 and RB51
… one virulent (2308) and two attenuated (19 and RB51) strains of B. abortus in the pregnant mouse. When 10<sup>5.7</sup> strain 2308 organisms were administered intraperitoneally to BALB/c mice in midgestation, by 9 days post-inoculation they consistently produced a severe, necro-suppurative …
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Unraveling the host innate immune response to a respiratory model of Brucella abortus
… exposure. Protection by B. abortus rough vaccine strains RB51 and RB51SOD is through strong CD4⁺ Th₁ and CD8⁺ Tc₁ adaptive immunity. However, limited information is available on how they stimulate innate immunity. This knowledge is critical for improving these vaccines for their potential use in …
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Intracellular growth of Brucella abortus and B. melitensis in murine macrophage-like cell lines and partial characterization of a biologically active extract from B. abortus strain RB51
… vitro in the form of the abilities of Brucella strains to grow and replicate within macrophages. Furthermore, it was of interest to see if the in vitro model was capable of assessing the degree of attenuation of the Brucella. Various strains of B. abortus and B. melitensis were used to infect …
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Mathematical models of immune responses following vaccination with application to Brucella infection
… used vaccines are Brucella abortus vaccine strain 19 and strain RB51. Both vaccines have been shown to be effective, but the mechanisms of immune responses following vaccination with either of the vaccines are not understood yet. In this thesis we analyze the immunological data obtained …
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Expression of Bacillus Anthracis Protective Antigen in Vaccine Strain Brucella Abortus Rb51
… protection against brucellosis. B. abortus strain RB51 has been shown to be useful in eliciting protective cell mediated immunity and humoral responses against Brucella in cattle and other animal species. Since the protective antigen (PA) of B. anthracis is known to induce protective …
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Development and testing of recombinant B. abortus RB51 vaccine strains carrying M. tuberculosis protective antigens
… TB. Bacille Calmette-Guérin (BCG), an attenuated strain of M. bovis, is the only licensed TB vaccine in the world. Clinical studies have shown childhood vaccination with BCG to be protective against disseminating and meningeal forms of TB. However, the efficacy of BCG against pulmonary TB in …
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NOVEL STRATEGIES TO DEVELOP BETTER BRUCELLOSIS VACCINES USING BRUCELLA ABORTUS RB51 AND B. NEOTOMAE
… Brucella species in some hosts. B. abortus strain RB51 is a stable rough attenuated mutant which is used as a licensed live vaccine for bovine brucellosis in the United States and several other countries. Previous studies have shown that the wboA gene, which encodes a glycosyltransferase …
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Genetic and Immunological Analyses of a Brucella abortus Protein Exhibiting Lectin-like Properties
… of this protein in B. abortus vaccine strain RB51 was achieved using Brucella groE and sodC promoters as well as its own promoter. Protection and clearance studies were performed in mice to determine the role of this protein in Brucella immunity and pathogenesis. Inoculation with either …
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Evaluation of the Aging Immune System Using a Mouse Model of Brucella Infection
… mice were infected with wild-type B. abortus strain 2308. The old and young mice were also vaccinated with vaccine B. abortus strain RB51 over-expressing Cu-Zn superoxide dismutase (SOD) and then challenged with B. abortus strain 2308 to determine the effect of vaccination in old vs. young …
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Brucella abortus RB51 vaccine: Testing its Spectrum of Protective and Curative Characteristics
… The official brucellosis vaccine in the US is strain RB51 (RB51). It elicits protective cell-mediated immunity (CMI) against BA infections. Mycobacterium avium subspecies paratuberculosis (MAP) causes paratuberculosis in ruminants. It is a slow growing intracellular parasite that requires CMI …
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Approaches towards vaccine development against Neospora caninum
… caninum research has been conducted with several strains of mice and the different strains of mice vary in their susceptibility to infection with N. caninum, there is a need to develop a standard lab animal model for N. caninum. A gerbil and a C57BL/6 mouse model for N. caninum vaccine testing …
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The production and characterization of a putative anti-idiotypic antibody to tumor necrosis factor-α
… an effect on the killing of Brucella abortus strain RB51 by peritoneal macrophages, whereas neither TNFa nor Ab2f3 had an effect on the killing of strain 2308 by macrophages. These results, again indicate that TNFa and Ab2f3 have parallel dbactericidal effects and that Ab2f3 is capable of …
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