Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"store-operated calcium entry"”.
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Store-Operated Calcium Entry And Its Function During Fertilization In Porcine Eggs
… the depletion of intracellular Ca<sup>2+<sup> stores leads to Ca<sup>2+<sup> influx across the plasma membrane though a process known as store-operated Ca<sup>2+<sup> entry. It not only plays a critical role in the replenishment of the Ca<sup>2+<sup> stores but it is also responsible for the …
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Structure-based development of novel chemical scaffolds as inhibitors of the store-operated calcium entry pathway
Calcium (Ca2+) is an intracellular messenger regulating various physiological activities. The ‘store-operated calcium entry’ (SOCE) is a significant, almost ubiquitous Ca2+ signaling pathway and is triggered when intracellular Ca2+ stores (e.g., endoplasmic reticulum, ER) are depleted, either …
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S-Acylation Is A Key Regulator of Orai1/Stim1-Mediated Store-Operated Calcium Entry In T Cells
… (CRAC) channel which is required for store-operated Ca<sup>2+</sup> entry (SOCE) in T cells and subsequent signaling events leading to T cell activation, proliferation, and differentiation. Plasma membrane (PM)-localized Orai1 is the pore-forming subunit of the CRAC channel, and STIM1 …
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Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells
The store-operated calcium entry (SOCE) pathway is an important route for generating cytosolic Ca2+ signals that regulate a diverse array of biological processes. Abnormal SOCE seem to underlie several diseases that notably include allergy, inflammation, acute pancreatitis and cancer. Therefore, …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… synthetic VSMC specific therapeutic target. Store operated calcium entry (SOCE) allows refilling of depleted ER-Ca2+ stores in non-excited cells, including in synthetic VSMCs, and supports migration and proliferation of synthetic VSMCs. Herein, we identify a critical role for PDE1C in …
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MicroRNA-184: A Multifaceted Regulator of Epidermal Keratinocyte Biology
… on Ca2+ and the major keratinocyte Ca2+ entry pathway called store-operated calcium entry (SOCE). Furthermore, miR-184 was upregulated in a cohort of eight psoriasis patient samples. By modulating miR-184 expression it was elucidated that miR-184 promotes early keratinocyte …
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Remodelado de la entrada de calcio en la angiogénesis: papel de las proteínas ORAI1 Y SARAF
… cambio de [Ca2+]i regulado por SOCE, del inglés store-operated calcium entry, tiene un papel fundamental en el proceso de angiogénesis. Sin embargo, siguen siendo escasos los conocimientos sobre el papel que desempeñan en este proceso sus proteínas claves, entre ellas, SARAF, el emergente factor …
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HUMAN CLCA2 MODULATES THE CONDUCTANCE OF CALCIUM-ACTIVATED CHLORIDE CHANNELS BY REGULATION OF INTRACELLULAR CALCIUM
… of these diseases by modulating an unidentified Calcium-activated Chloride Channel (CaCC). Recent evidence indicates Ano1 to be the mediator of strong quintessential calcium-activated chloride current in several cell types. Ano1 is highly expressed in airway epithelium and downregulated in cystic …
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Modulation of cyclic adenosine monophosphate (cAMP) signalling and its therapeutic potential: pharmacological characterisation of PDE inhibitors
… identify the role of possible crosstalk between calcium through SOCE (store-operated calcium entry) and cAMP pathways, which both were found to contribute to cell growth modulation. The effect of the elevation of intracellular cAMP on cell proliferation was further explored through the direct …
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The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels
… acinar cell exocytosis requires precise calcium (Ca2+) signals. When cytosolic Ca2+ levels remain high, cellular functions are disrupted, which is associated with initiation of pancreatitis. Ca2+ signals are achieved through regulating endoplasmic reticulum (ER) stores, Ca2+ATPases, and …
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Novel Roles of PACS-1 Within the Nucleus and the Regulated Secretory Pathway
… nuclear trafficking, the impact of PACS-1 on calcium homeostasis, and PACS-1 regulation of membrane protein trafficking within the regulated secretory pathway. First, our results establish PACS-1 motifs that regulate nuclear localization through the classical nuclear trafficking pathway. …