Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"stochastic simulations"”.
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A learning method for the approximation of discontinuous functions for stochastic simulations
Surrogate models for computational simulations are inexpensive input-output approximations that allow expensive analyses, such as the forward propagation of uncertainty and Bayesian statistical inference, to be performed efficiently. When a simulation output does not depend smoothly on its inputs, …
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Bridging the Gap between Deterministic and Stochastic Modeling with Automatic Scaling and Conversion
… networks have been built. Deterministic simulations of these models can show only average dynamics of the systems. However, stochastic simulations of macromolecular regulatory models can account for behaviors that are introduced by the noisy nature of the systems but not revealed by …
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Hybrid Modeling and Simulation of Stochastic Effects on Biochemical Regulatory Networks
… cell cycles in the presence of inevitable noise. Stochastic modeling is viewed as a key paradigm to study the effects of intrinsic and extrinsic noise on the dynamics of biochemical networks. A detailed quantitative description of such complex and multiscale networks via stochastic modeling poses …
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Physical Aspects of Min Oscillations in Escherichia Coli
… protein distributions. Moreover, we perform stochastic simulations based on a microscopic description, whereby the probability for each event is calculated according to the corresponding probability in the master equation. Starting from this microscopic description, we derive Langevin …
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Analysis Methods to Control Performance Variability and Costs in Turbine Engine Manufacturing
… code, component clearance loss models, and stochastic simulations, regions of feasible design space can be explored that allow for a pre-determined level of engine reliability. As expected, constraints such as spool speed and fuel consumption that are highly sensitive to certain component …
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The role of physical interactions in shaping the genetic diversity of spatially expanding phage and bacterial populations
… effects on the evolution of the phage. Using stochastic simulations and an analytic calculation of the rate of diversity loss, I find the strength of implicit density-dependence at which the scaling between the effective population and the total viral population maps to that of semi-pushed and …
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Fast simulation of stochastic biochemical reaction networks on cytomorphic chips
… behavior or loading; they exhibit high levels of stochasticity (noise) that require ex- pensive Gillespie algorithms and random-number generation for accurate simulations; and, they routinely operate with nonlinear statics and dynamics. Hence, such simulations are extremely computationally …
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Stochastic Modeling and Simulation of Multiscale Biochemical Systems
… in a single cell, which calls for quantitative stochastic models for gene and protein networks at cellular levels that match well with the data and account for cellular noise. This dissertation studies a stochastic spatiotemporal model of the Caulobacter crescentus cell cycle. A two-dimensional …
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Simulation based modeling of the elastic properties of structural wood based composite lumber
… created based on principles of deterministic and stochastic simulations. Generated elastic parameters were validated against experimentally measured MOE values. Reasonably good agreement between the simulated and actual elastic constants confirmed the usefulness of the developed models. The …
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First Exit Time Analysis for the Stochastic Reaction Diffusion Process in a One Dimensional Domain
Recent advances in modeling stochastic reaction–diffusion (RD) process have focused on particle-based and master equation formulations. While these models offer strong theoretical foundation, a practical challenge remains: how does the choice of spatial discretization affect the accuracy and …
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Tropical cyclones within the sedimentary record : analyzing overwash deposition from event to millennial timescales
… events has remained relatively constant. Stochastic simulations of hurricane overwash show that breaks in activity at Vieques are extremely long and unlikely to occur under the current hurricane climatology and the present barrier morphology. Periods of less frequent hurricane deposition …
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Tropical cyclones within the sedimentary record : analyzing overwash deposition from event to millennial timescales
… events has remained relatively constant. Stochastic simulations of hurricane overwash show that breaks in activity at Vieques are extremely long and unlikely to occur under the current hurricane climatology and the present barrier morphology. Periods of less frequent hurricane deposition …
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Techniques for stochastic simulation of complex electromagnetic and circuit systems with uncertainties
… set of tools and methodologies that perform fast stochastic characterization and simulation of uncertainties in electromagnetic and circuit systems. Background information on polynomial chaos and fast stochastic numerical techniques is reviewed, and discussion is offered on comparison of different …
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High Precision Binary Trait Association on PhylogeneticTrees
… in microbial populations. SimPhyNI uses stochastic simulations of trait evolution on phylogenetic trees to detect positive and negative associations with high precision and recall. Benchmarking on large synthetic datasets, SimPhyNI achieved a precision-recall AUC (PR AUC) of 0.987 and …
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Collective analog bioelectronic computation
… of electronic current flow in a transistor, stochastic effects are automatically incorporated into the circuit architecture, allowing highly computationally intensive stochastic simulations of large-scale biochemical reaction networks to be performed rapidly. I show that the exponentially …
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External Network Manufacturing Capacity Design and Procurement in the Pharmaceutical Industry
… linearized, multi-objective optimization model. Stochastic simulations reveal that connecting all products and assets in the portfolio through cross-validations reduces the supply shortfall by 6%, while limiting the impact on a single product. However, in order not to be performance-constrained …
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The Role of Virus-Host Interactions in the Evolutionary Dynamics of Bacteriophage Populations
… leading to a phage population in which stochastic fluctuations are much weaker. This allows beneficial mutations to establish more easily and deleterious ones to be purged, making the phage population more adaptable to changes in the environment. To facilitate better comparisons between …
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Impact of Stochastic Transcriptional Delay on Gene Networks
… networks is to incorporate dynamical delay. The stochastic nature of the reactions necessary to produce protein leads to a waiting time that is randomly distributed, complicating simulation and analysis. We examine this problem using different examples and approaches. First, we describe how …
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Stochastic J-integral and realiability of composite laminates based on a computational methodology combining experimental investigation, stochastic finite element analysis and maximum entropy method
The present thesis concerns itself with the stochastic fracture behavior and the reliability of laminated composites. A computational approach combining the Stochastic Finite Element Method (SFEM), the Maximum Entropy Method (MEM), and experimental investigation has been developed. Using this …
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Modeling and Control of Queuing Networks: Applications to Airport Surface Operations
… logic that was recently field-tested, using stochastic simulations. We also investigate the impact of uncertainty in airline-supplied estimates of traffic demand on the efficacy of congestion control algorithms, and quantify the benefits of reducing this uncertainty. Finally, we note that the …
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