Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"stimulation of cells"”.
-
Light-triggered release of bioactive compounds from HA/PLL multilayer films for stimulation of cells
The concept of targeting cells and tissues by controlled delivery of molecules is essential in the field of biomedicine. The layer-by-layer (LbL) technology for the fabrication of polymer multilayer films is widely implemented as a powerful tool to assemble tailor-made materials for controlled drug …
-
Microfluidic Concentration Gradient Generation and Integrated Magnetic Sorting of Microparticles
Microfluidic systems, with their feature size similar to that of biological cells, have great potential for cell manipulation and interrogation. On the other hand, the process of drug discovery involves vast amount of tests of candidate drug molecules with cells, and hence requires intensive …
-
Microfluidic biomechanical and electrical devices for rapid analysis of cells and organelles
… focuses on micro devices aimed at rapid analysis of cells and subcellular organelles. These devices take advantage of microfabrication techniques to create environment suitable for biomechanical and biochemical stimulation of cells, to break cell membranes to extract the intracellular materials, …
-
Microfluidic devices for studying early response of cytokine signaling
… the design, fabrication, and characterization of a microfluidic device integrated with cell culture, cell stimulation, and protein analysis as a single device towards an efficient and productive cell-based assay development. In particular, this thesis demonstrates the feasibility of culturing …
-
Potential roles for transforming growth factor-B during terminal differentiation of ocular lens cells /
During terminal differentiation, lens fiber cells permanently withdraw from the cell cycle, migrate posteriorly along the lens capsule, become greatly elongated and eliminate all cellular organelles. Lens fiber differentiation may be controlled by various factors within the ocular environment. The …
-
Macrophage cytokines as correlate of differential resistance to African trypanosomiasis
… in resistance to trypanosomiasis. The expression of mRNA and/or production of cytokines (IL-6, IL-10, TNF-α, TGF-β1 and IL-12) and nitric oxide (NO) by macrophages from C57Bl/6 and BALB/c mice in response to 'T. congolense' or 'T. brucei' were studied. The bone marrow-derived macrophage cell line …
-
The role of the kisspeptin receptor, KISS1R, in breast cancer cell proliferation, invasion and migration.
… by kisspeptin results in the activation of phospholipase C, calcium mobilization and ERK1/2 phosphorylation. Moreover, kisspeptin production has been linked to inhibition of metastasis in many cancers. However, in breast cancer, conflicting studies have shown that kisspeptin and KISS1R …
-
Cellular and Molecular Mechanisms of Immunoregulation In Vivo
… pro-and anti-inflammatory responses. Absence of regulation of pro-inflammatory responses can lead to lethal tissue damage and pathologies such allergy and autoimmune disease. However, aberrant anti-inflammatory responses allow for uncontrolled pathogen replication, and progression of …
-
Novel Fluorescent Sensors for Dynamic Intracellular Signalling
Protein kinase C (PKC), comprised of ten isozymes, is an abundant regulator of cellular function. PKC activity in living cells is commonly assayed in in vitro experiments with cell lysate. Monitoring PKC activity in single living cells is not possible with such experiments. This thesis presents a …
-
REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… progression. Endocytosis is a critical regulator of EGFR activity. We have previously identified a novel endocytic route of the EGFR, non-clathrin endocytosis (NCE), which is activated only after stimulation with high doses of the ligand epidermal growth factor (EGF). Unlike canonical …
-
The Interplay of RSV and IFITs: A comprehensive analysis of human and bovine Interferon-Induced Proteins with Tetratricopeptide Repeats induction and interaction with human and bovine Respiratory Syncytial Virus
… proteins conserved across vertebrates. Following stimulation of cells, they are amongst the most highly induced genes, although the patterns of induction kinetics of individual IFIT proteins are species-, cell type-, tissue-, virus-, and inducer-specific. Most mammals, including Homo sapiens and …
-
Mechanisms of glucocorticoid pro-inflammatory effects on CCL20: crosstalk and synergy
… molecules. GCs classically induce the expression of antiinflammatory genes, while repressing pro-inflammatory genes via its endogenous cell receptor; the glucocorticoid receptor (GR). Emerging evidence, however, suggests that the mechanisms of GR action are more complex than previously assumed, …
-
Cell Biology of the ICA69 protein family in Neurosecretory cells
… and synaptic-like microvesicles. Thus, the study of beta-cell autoantigens with yet unknown function may provide novel insight into the secretory machinery of beta-cells and led to the discovery of novel pathways. Islet cell autoantigen of 69 kDa (ICA69) is a T1D autoantigen. It is a cytosolic …
-
The G protein-coupling specificity of D2-like dopamine receptors
The G-protein coupling specificity of D2-like dopamine receptors was investigated using both receptor-G protein fusions and membranes of cells in which pertussis toxin-resistant mutants of individual Gi-family G proteins could be expressed in an inducible fashion. A range of ligands displayed …